Category: 5750-74-3

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5750-74-3, name is 2,5-Dichloro-4-methoxypyrimidine, the common compound, a new synthetic route is introduced below. Recommanded Product: 5750-74-3

General procedure: Example 8: 6-Chloro-5-(5-chloro^t-(methylamino)pyrimidin-2-ylamino)-2- methylisoindolin-l-one A mixture of 5-amino-6-chloro-2-methylisoindolin-l-one (61 mg, 0.31 mmol), 2,5-dichloro-4-methoxypyrimidine (55 mg, 0.31 mmol) and pTSA (59 mg, 0.31 mmol) in dioxane (4 mL) was heated to 100 C for 18 h. DCM (10 mL) and saturated aqueous NaHC03 (10 mL) were added and the mixture was passed through a hydrophobic frit. The solvent was removed in vacuo and purification of the residue via reversed phase preparative HPLC gave 6-chloro-5-(5-chloro-4-(methylamino)pyrimidin-2-ylamino)-2- methylisoindolin-l-one (26 mg, 25%) as an off-white solid. LCMS (10 cm ESCI Formic MeCN): [M + H]+ = 338 at 2.83 min. ? NMR (400 MHz, d6- DMSO): ? 8.46 (s, IH), 8.29 (s, IH), 8.01 (s, IH), 7.73 (s, IH), 7.41 (q, J 4.6, IH), 4.48 (s, 2H), 3.08 (s, 3H), 2.91 (d, J4.6, 3H).

The synthetic route of 5750-74-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BAKER-GLENN, Charles; CHAMBERS, Mark; CHAN, Bryan K.; ESTRADA, Anthony; SWEENEY, Zachary Kevin; WO2013/79505; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5750-74-3, name is 2,5-Dichloro-4-methoxypyrimidine. A new synthetic method of this compound is introduced below., Product Details of 5750-74-3

A solution of (2S,4R)-tert-butyl 4-amino-2-methylpyrrolidine-l-carboxylate (200 mg, 1.0 mmol), 2,5-dichloro-4-methoxypyrimidine (358 mg. 2.0 mmol) and K2C03 (226 mg, 2.0 mmol) in DMSO (10 mL) was stirred at RT for 2 hrs. The reaction mixture was diluted with water (30 mL) and extracted with EA (20 mL*3). The combined organic layers were washed with water (50 mL) and brine (50 mL), dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography (PE:EA = 1 : 1) to afford (2S,4R)-tert-butyl 4-((5-chloro-4- methoxypyrimidin-2-yl)amino)-2-methylpyrrolidine-l-carboxylate (100 mg, 30%) as a white solid. [M+H] Calc?d for CisH^ClN^s, 343.1; Found, 343.1

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Reference:
Patent; KINNATE BIOPHARMA INC.; KANOUNI, Toufike; ARNOLD, Lee D.; KALDOR, Stephen W.; MURPHY, Eric A.; TYHONAS, John; (0 pag.)WO2020/6497; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia