Category: 5750-76-5

5750-76-5, A common compound: 5750-76-5, name is 2,4,5-Trichloropyrimidine,molecular formula is C4HCl3N2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Take 3 (23.44 mmol) and DIPEA (4.5 g, 35.16 mmol)2,4-Dichloro-5-R-pyrimidine (3.8 g, 23.44 mmol) was slowly added to 50 mL of 1,4-dioxane.After heating at 60 C for 2 hours,The reaction is complete, cooling,Add 400 mL of water, precipitate a yellow-white solid, suction filtration, and dry to give a white solid.The next reaction was not directly purified.

With the rapid development of chemical substances, we look forward to future research findings about 5750-76-5.

Reference:
Patent; Dalian Medical University Affiliated The First Hospital; Dalian Medical University; Yuan Hong; Li Si; Zhao Jingyuan; Wu Xiangdong; Wang Xiaoxi; Wang Nan; Yao Bingjie; Zhao Dan; Yao Yao; Sun Xiuli; Ma Xiaodong; (23 pag.)CN108610295; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5750-76-5, name is 2,4,5-Trichloropyrimidine, molecular formula is C4HCl3N2, molecular weight is 183.4231, as common compound, the synthetic route is as follows.5750-76-5

General procedure: To a solution of compound 15 (37.65 mmol) in 1,4-dioxane (50 mL) were added diisopropylethylamine (7.3 g, 56.48 mmol) and 2,4,5-trichloropyrimidine (6.9 g, 37.65 mmol) or 2,4-dichloro-5-fluoropyrimidine (6.3 g, 37.65 mmol). The reaction was heated to 60 C and stirred for 2 h. After being cooled to room temperature, the reaction mixture was added to water (300 mL). The precipitate was filtered, and the filtered cake was rinsed with additional cool water and dried in a vacuum oven to give the compound 16a,b (91%), which was used without further purification.

Statistics shows that 5750-76-5 is playing an increasingly important role. we look forward to future research findings about 2,4,5-Trichloropyrimidine.

Reference:
Article; Ge, Yang; Yang, Haijun; Wang, Changyuan; Meng, Qiang; Li, Lei; Sun, Huijun; Zhen, Yuhong; Liu, Kexin; Li, Yanxia; Ma, Xiaodong; Bioorganic and Medicinal Chemistry; vol. 25; 2; (2017); p. 765 – 772;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia