Synthetic Route of 580-16-5,Some common heterocyclic compound, 580-16-5, name is 6-Hydroxyquinoline, molecular formula is C9H7NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Procedure C. The aromatic alcohol (1.2 mmol) and PhOCSCl (1.8 mmol) were dissolved in 10 mL of CH2Cl2 or MeCN. CsF-Celite (2.4 mmol) was then added to form a heterogeneous mixture. The reaction mixture was stirred at room temperature for 2-6 hours and monitored by TLC. Then reaction mixture was diluted with CH2Cl2 and washed with brine. Organic layers were combined and dried with Na2SO4 and solvent was removed under reduced pressure. The crude mixture was purified by column chromatography to afford the corresponding thiocarbonate.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Hydroxyquinoline, its application will become more common.