Adding a certain compound to certain chemical reactions, such as: 580-19-8, name is Quinolin-7-amine, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 580-19-8, Recommanded Product: Quinolin-7-amine
(c) (6-Chloropyrimidin-4-yl)-quinolin-7-yl-amine. A mixture of 4,6-dichloro-pyrimidine (1.04 g, 7.0 mmol, Lancaster), 7-aminoquinoline (1.00 g, 7.0 mmol, SynChem Inc.) and potassium carbonate (1.93 g, 14.0 mmol) in DMF (5.0 mL) was heated at 100¡ã C. with stirring for 24 h. The reaction mixture was allowed to cool to room temperature, diluted with water, and the resulting solid precipitate was filtered. The filter cake was dissolved in a mixture of CH2Cl2 and MeOH (3:1), washed with water and brine, dried over Na2SO4, and filtered. The filtrate was evaporated under reduced pressure, and the brown-yellow solid residue was suspended in CH2Cl2, filtered, and washed with CH2Cl2. The filter cake was dried in vacuo to give the title compound as a light-yellow solid. MS (ESI, pos. ion.) m/z: 257 (M+1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Quinolin-7-amine, and friends who are interested can also refer to it.