Category: 583878-42-6

Application of 583878-42-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.583878-42-6, name is Ethyl 4-chloro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate, molecular formula is C9H11ClN2O2S, molecular weight is 246.71, as common compound, the synthetic route is as follows.

[00248] To a solution of ethyl 4-chloro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate (65 g) in THF (1000 niL) and triethylamine (110 niL, 0.81 mole) was added ethylamine (2.0 M in THF, 0.81 mole) at 0 0C. This reaction mixture was stirred at room temperature overnight and then solvents were removed on a rotary evaporator. H2O was added and the mixture extracted with ethyl acetate several times. Solvents from the combined organic layers were removed on a rotary evaporator affording 58 g (86% yield) of ethyl 4-(ethylamino)-6- methyl-2-(methylthio)pyrimidine-5-carboxylate. This material was used as such without further purification.

The chemical industry reduces the impact on the environment during synthesis 583878-42-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; EXELIXIS, INC.; WO2008/127678; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 583878-42-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.583878-42-6, name is Ethyl 4-chloro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate, molecular formula is C9H11ClN2O2S, molecular weight is 246.71, as common compound, the synthetic route is as follows.

Intermediate 1 1Ethyl 4-({3-r3-({r(1 , 1-dimethylethyl)oxylcarbonyl}amino)propyllphenyl}amino)-6-methyl-2-(methylthio)-5-pyrimidinecarboxylateTo a solution of 1 ,1-dimethylethyl [3-(3-aminophenyl)propyl]carbamate (390 mg, 1.558 mmol) in DMF (5 ml.) were added ethyl 4-chloro-6-methyl-2-(methylthio)-5- pyrimidinecarboxylate (307 mg, 1.246 mmol) and DIEA (0.298 ml_, 1.714 mmol), and the reaction mixture was stirred at 75 0C overnight. The reaction was then concentrated and the residue was purified using column chromatography (silica gel, 0% to 50% EtOAc gradient in hexane) to afford the product (210 mg, 29% yield). MS: M(C23H32N4O4S) = 460.59, (M+H)+ = 461.6 1 H NMR (400 MHz, CD3OD) delta ppm 1.44 – 1.47 (m, 12 H), 1.77 – 1.85 (m, 3 H), 2.52 (s, 3 H), 2.62 (s, 3 H), 2.65 (d, J = 8.6 Hz, 2 H), 3.09 (t, J = 7.0 Hz, 2 H), 4.45 (q, J = 7.2 Hz, 2 H), 4.64 (br. s., 1 H), 7.01 (d, J = 7.6 Hz, 1 H), 7.28 (t, J = 7.8 Hz, 1 H), 7.42 (d, J = 1.3 Hz, 1 H), 7.55 – 7.58 (m, 1 H).

The chemical industry reduces the impact on the environment during synthesis 583878-42-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; ATKINSON, Francis, Louis; AXTEN, Jeffrey, Michael; CICHY-KNIGHT, Maria; MOORE, Michael, Lee; PATEI, Vipulkumar, Kantibhai; TIAN, Xinrong; WELLAWAY, Christopher, Roland; DUNN, Allison, K.; WO2010/19637; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 583878-42-6, Adding some certain compound to certain chemical reactions, such as: 583878-42-6, name is Ethyl 4-chloro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate,molecular formula is C9H11ClN2O2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 583878-42-6.

To a solution of Intermediate III-A1 (400 mg, 1 mmol) dissolved in MeOH (4 mL) was added conc. HCl (4 mL) . The resulting mixture was concentrated at 50 to dryness. The residue was dissolved in n-BuOH (20 mL) , and then added DIEA (1 mL) and ethyl 4-chloro-6-methyl-2- (methylthio) pyrimidine-5-carboxylate (246 mg, 1 mmol) . The mixture was stirred at rt. for 2h, and then concentrated to remove the solvent. The residue was purified by flash column chromatography to afford the title compound as a solid (500 mg) . Yield: 97.8. MS (ESI) : calcd. value for C24H23ClN6O3S is 510.12, m/z measured value is 511.1 (M+1)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 583878-42-6, Ethyl 4-chloro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DAI, Guangxiu; JIA, Hong; ZHANG, Zhulin; WENG, Jianyang; VENABLE, Jennifer Diane; BEMBENEK, Scott Damian; CHAI, Wenying; MEDUNA, Steven Paul; KEITH, John Matthew; ECCLES, Wendy; LEBSACK, Alec Donald; JONES, William Moore; SMITH, Russell Christopher; (195 pag.)WO2016/119707; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia