Category: 58536-46-2

Related Products of 58536-46-2, Adding some certain compound to certain chemical reactions, such as: 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine,molecular formula is C22H15BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58536-46-2.

A 250 ml four-necked flask was charged with 0.02 mol of C5 and 0.022 mol of C1 under a nitrogen atmosphere.0.06 mol sodium t-butoxide, 2×10-4 mol Pd2(dba)3 [tris(dibenzylideneacetone) dipalladium], 2×10-4 mol P(t-Bu)3 (tri-tert-butylphosphine), 150ml of toluene, heated to reflux for 24 hours, sampling the plate, the reaction is complete, naturally cooled, filtered, the filtrate is steamed, passed through the silica gel column,The target product was obtained with a purity of 98.5% and a yield of 57.50%.

According to the analysis of related databases, 58536-46-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Ye Zhonghua; Li Chong; Xu Kai; Zhang Xiaoqing; Zhang Zhaochao; (38 pag.)CN108239070; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H15BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C22H15BrN2

F-4 8.0g (23.23mmol), 4- (4- bromophenyl) pyridine-2,6-diphenyl (4- (4-bromophenyl) -2,6-diphenylpyrimidine), 9.9g (25.55mmol), Pd2 (dba) 3 2.1g (2.323mmol), P (t-Bu) 3 0.22g (2.323mmol), sodium tert-butoxide 14.1g (69.69mmol) and stirred for 6 hours under the reflux of toluene in 120C 150mL. After cooled back to room temperature after completion of the reaction the solid is created filter was washed with ethyl acetate (EA), methanol (MeOH). Then after the solid boiled with excess Toluene filter to obtain the title compound 1-482 10.8g (71%).

With the rapid development of chemical substances, we look forward to future research findings about 58536-46-2.

Reference:
Patent; HEESUNG MATERIAL LTD.; LEE, JEONG HYEON; JONG, SOO JIN; KIM, KI YOUNG; KIM, DONG JOON; PARK, CHAN JOON; CHOI, JIN SEOK; CHOI, DAE HYEOK; EUM, SONG JIN; LEE, JOO DONG; (164 pag.)KR101579289; (2015); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 58536-46-2, Adding some certain compound to certain chemical reactions, such as: 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine,molecular formula is C22H15BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58536-46-2.

General procedure: A mixture of 4-(4-bromophenyl)-2,6-diphenylpyrimidine (4.06 g, 10.5 mmol), compoundBFCz (2.57 g, 10 mmol), CuI (0.19 g, 1 mmol), K2CO3 (6.9 g, 50 mmol),18-crown-6 (0.264 g, 1 mmol) were dissolved in 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU 10 mL) and stirred at 180 Cunder a nitrogen atmosphere for 48 h. After cooling to room temperature,the mixture was extracted with CH2Cl2 and water. The organicphase was dried over anhydrous MgSO4 and filtered. After removal ofthe solvent, the residue was purified by column silica gel chromatography(PE: DCM=10:1) and recrystallized to afford a white productin 64% yield (3.6 g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 58536-46-2, 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Qing; Xiang, Songpo; Huang, Zhi; Sun, Shuaiqiang; Ye, Shaofeng; Lv, Xialei; Liu, Wei; Guo, Runda; Wang, Lei; Dyes and Pigments; vol. 155; (2018); p. 51 – 58;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 58536-46-2, 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C22H15BrN2, blongs to pyrimidines compound. COA of Formula: C22H15BrN2

Synthesis of Intermediate GIn a 500 ml three necked round bottom flask, 38.7 g (100 mmol) of 4-(4-bromophenyl)-2,6-diphenylpyrimidine, 2.7 g (3 mmol) of Pd2(dba)3,2.21 g (6 mmol) tricyclohexylphosphine,55.9 g (220 mmol) of bis (pinacorate) diborane and 39.25 g (400 mmol) of potassium acetate put it in nitrogen,300 ml of 1,4-dioxane was added and stirred for 4 hours at reflux.After completion of the reaction, the mixture was extracted with Methylene Chloride, the organic layer was dried with MgSO4, purified by column chromatography, and crystallized with n-Hexane to give 36 g (82.9.%) As intermediate G.

The synthetic route of 58536-46-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jinung Industry Co., Ltd.; Lee Eung; Lee Jong-ryun; Cho Eun-sang; Lee Ji-hwan; Kuk Chang-hun; (29 pag.)KR102052332; (2019); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H15BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyrimidines

Add intermediate IF-1 (12.18g, 31.45mmol) to a 250mL three-necked flask containing THF (100mL), and add n-butyllithium (1.99g, 31.09mmol) dropwise at -78 C. After the dropwise addition, the temperature is maintained for 1h. Trimethyl borate (4.61 g, 44.42 mmol) was then added dropwise, and the temperature was kept at room temperature for 1 h, followed by stirring overnight; hydrochloric acid (2 mol / L) was added to adjust the pH to neutral,After filtration, a white crude product was obtained, which was slurried with n-heptane to obtain a white solid intermediate I-F (7.68 g, yield 70%).

With the rapid development of chemical substances, we look forward to future research findings about 58536-46-2.

Reference:
Patent; Shanxi Laite Optoelectric Materials Co., Ltd.; Ma Tiantian; Yang Min; Nan Peng; (69 pag.)CN110615759; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 58536-46-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H15BrN2, molecular weight is 387.27, as common compound, the synthetic route is as follows.

250ml four-necked flask, under a nitrogen atmosphere,Add 0.01 mol of raw material A8, 0.025 mol of raw material B4,0.04 mol of sodium tert-butoxide, 2 x 10-4 mol of Pd2(dba)3,2×10-4 mol of tri-tert-butylphosphine, 150 ml of toluene,Heat reflux for 24 hours, sample the plate, reaction is complete;Cool naturally, filter, rotate the filtrate, pass the silica gel column,Got the target product 78,Purity 97.8%, yield 64.3%.

Statistics shows that 58536-46-2 is playing an increasingly important role. we look forward to future research findings about 4-(4-Bromophenyl)-2,6-diphenylpyrimidine.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Cai Xiao; Li Chong; Zhang Zhaochao; Tang Dandan; Zhang Xiaoqing; (53 pag.)CN107586299; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 58536-46-2 ,Some common heterocyclic compound, 58536-46-2, molecular formula is C22H15BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

11.9 g (34 mmol) of 4-(4-bromophenyl)-2,6-diphenylpyrimidine are dissolved in 300 ml of THF and subsequently cooled to -100 C. 22 ml (38 mmol) of a 1.6M solution of n-butyllithium in hexane are slowly added dropwise to the reaction mixture with stirring. The reaction mixture is stirred for 30 min. 200 ml (34 mmol) of a solution of 2-bromo-1,3-diphenyl-2,3-dihydro-1H-benzo-1,3,2-diazaborole in toluene are subsequently added dropwise. The reaction mixture is warmed to 0 C. over a period of 4 h, then 600 ml of ethanol are added dropwise. The precipitated solid is recrystallised from toluene and subsequently sublimed. Yield: 11 g (60% of theory, purity >99.9%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 58536-46-2, 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck Patent GmbH; Mujica-Fernaud, Teresa; Parham, Amir Hossain; Stoessel, Philipp; Pflumm, Christof; Buesing, Arne; Eberle, Thomas; (30 pag.)US10032992; (2018); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine. A new synthetic method of this compound is introduced below., category: pyrimidines

Under an Ar gas atmosphere, the intermediate body X3 (4.8 g, 10 mmol), the intermediate body X7 (3.9 g, 10 mmol), an aqueous solution of 2M sodium carbonate (12 ml), toluene (20 ml), DME (20 ml) and Pd(PPh3)4 (0.35g) were stirred for 16 hours at a reflux temperature. After the reactant solution was cooled down to the room temperature, toluene (200 ml) and water (100 ml) were added thereto to separate an organic phase. The residue obtained by concentrating the organic phase was refined by silica-gel column chromatography (a developing solvent: hexane-toluene) and was recrystallized by toluene twice to provide a target object (a compound No. 4) as a white solid. A yield of the compound No. 4 was 2.6 g and a yield rate thereof was 35%. FD mass analysis consequently showed that m/e was equal to 741 while a calculated molecular weight was 741

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 58536-46-2, 4-(4-Bromophenyl)-2,6-diphenylpyrimidine.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2489664; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H15BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 4-(4-Bromophenyl)-2,6-diphenylpyrimidine

Under a nitrogen atmosphere 2- (4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl) -1,10-phenanthroline (5.0 g, 13.08 mmol) 4- (4-bromophenyl) -2,6-diphenylpyrimidine (6.10 g, 15.96 mmol), tetrakis-triphenylphosphine palladium (0) (Pd (PPh3) 4) (0.75 g, 0.65 mmol) 4M potassium carbonate aqueous solution (10 mL), toluene 30 mL, ethanol 10 mL And the mixture was stirred under reflux for 12 hours. After the reaction was completed, 50 mL of H2O was added, and the mixture was stirred for 3 hours. The mixture was filtered under reduced pressure, separated by column chromatography using methylene chloride (MC) and methanol as an eluent, EN-145-1 (5.56 g, yield 75.6%).

With the rapid development of chemical substances, we look forward to future research findings about 58536-46-2.

Reference:
Patent; LG Display Co., Ltd.; Shin Ji-cheol; Joo Seong-hun; Ryu Seon-geun; Yoon Seung-hui; (44 pag.)KR2018/67321; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 58536-46-2, Adding some certain compound to certain chemical reactions, such as: 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine,molecular formula is C22H15BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58536-46-2.

General procedure: After completely dissolving a compound represented by Chemical Formula E1-P2 (7.8 g, 13.9 mmol) and a compound represented by Chemical Formula E1-A (3.7 g, 13.9 mmol) in tetrahydrofuran (THF) (70 mL), potassium carbonate (5.8 g, 41.8 mmol) dissolved in water (40 mL) was added thereto. After introducing tetrakistriphenyl-phosphinopalladium (0.5 g, 0.418 mmol) thereto, the result was stirred for 8 hours with heating. After lowering the temperature to room temperature, the reaction was terminated, and then the potassium carbonate solution was removed to filter white solids. The filtered white solids were washed twice each with THF and ethyl acetate to prepare a compound represented by Chemical Formula E1 (6.5 g, yield 70%). MS[M+H]+=665

According to the analysis of related databases, 58536-46-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LG CHEM, LTD.; HEO, Dong Uk; LEE, Dong Hoon; HUH, Jungoh; JANG, Boonjae; HAN, Miyeon; YANG, Junghoon; YUN, Heekyung; (301 pag.)US2020/48230; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia