Category: 58536-46-2

Electric Literature of 58536-46-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

wherein the fluoro compound in the atmosphere of nitrogen 13H-fluorenone[1,9-ab]carbazole (15.0g, 0.52mol), 4-(4-bromophenyl)-2,6-diphenyl-pyrimidine (19.03g , 0.57mol) and then completely dissolved in 240ml xylene and sodium tert- butoxide (5.94g, added 0.61mol), and bis(tri-tert-butylphosphine)palladium (0) (0.13g, 0.0026mol, insert a) after heating and stirring for 5 hours. After concentrated under reduced pressure the xylene in the filtrate cooled to room temperature, remove the base and recrystallized from ethyl acetate to the compound 1-17: to produce a (16.31g, yield 73%).

According to the analysis of related databases, 58536-46-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LG Chemical Co., Ltd.; Cha, Yong Bum; Kim, Jin Ju; (89 pag.)KR2016/29670; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 58536-46-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H15BrN2, molecular weight is 387.27, as common compound, the synthetic route is as follows.

General procedure: Intermediate 8 (2.9g, 10.0 mmol), Intermediate 2 (3.9g, 10.0 mmol), Pd(PPH3)4 (0.21g, 0.2 mmol), toluene (30 mL) and a 2M aqueous solution of potassium hydroxide (15 mL) were mixed under an argon atmosphere. The mixture was stirred at 80C for 7 hours. Water was added to the reaction solution to precipitate solid matters. The solid matters were washed with methanol. The solid matters obtained were filtrated and washed with heated toluene, and then dried to obtain 3.8 g of pale yellow powder. The pale yellow powder was identified as Aromatic amine derivative (H1) by FD-MS analysis.

Statistics shows that 58536-46-2 is playing an increasingly important role. we look forward to future research findings about 4-(4-Bromophenyl)-2,6-diphenylpyrimidine.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; KATO, Tomoki; ITO, Mitsunori; INOUE, Tetsuya; OGIWARA, Toshinari; HIBINO, Kumiko; EP2589596; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia