Category: 5948-71-0

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5948-71-0, name is Ethyl 4-(4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate, the common compound, a new synthetic route is introduced below. COA of Formula: C14H15ClN2O3

General procedure: To a solution of 3,4-dihydropyrimidin-2(1H)-one (1 mmol) in acetonitrile and water (10:2mL) in a 50 mL round-bottomed ask equipped with a condenser and a magnetic stirrer, 1,4-bis(triphenylphosphonium)-2-butene peroxo disulfate (1 mmol) was added in small portions.The reaction mixture was refluxed for the appropriate time indicated in Table 1. The progress of the reaction was monitored by TLC. Upon completion of the reaction, it was cooled to room temperature and filtered. Water (15 mL) was added and extracted with chloroform (3 × 15 mL). The combined organic layers solution was dried over MgSO4. The solvent was concentrated in vacuo; the resulting product was directly charged on a small silica gel column and eluted with a mixture of diethyl ether and n-hexane (1:4) to afford the pure product.

The synthetic route of 5948-71-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gorjizadeh, Maryam; Bulletin of the Korean Chemical Society; vol. 34; 6; (2013); p. 1751 – 1754;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5948-71-0, name is Ethyl 4-(4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate, the common compound, a new synthetic route is introduced below. COA of Formula: C14H15ClN2O3

General procedure: To a solution of 3,4-dihydropyrimidin-2(1H)-one (1 mmol) in acetonitrile and water (10:2mL) in a 50 mL round-bottomed ask equipped with a condenser and a magnetic stirrer, 1,4-bis(triphenylphosphonium)-2-butene peroxo disulfate (1 mmol) was added in small portions.The reaction mixture was refluxed for the appropriate time indicated in Table 1. The progress of the reaction was monitored by TLC. Upon completion of the reaction, it was cooled to room temperature and filtered. Water (15 mL) was added and extracted with chloroform (3 × 15 mL). The combined organic layers solution was dried over MgSO4. The solvent was concentrated in vacuo; the resulting product was directly charged on a small silica gel column and eluted with a mixture of diethyl ether and n-hexane (1:4) to afford the pure product.

The synthetic route of 5948-71-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gorjizadeh, Maryam; Bulletin of the Korean Chemical Society; vol. 34; 6; (2013); p. 1751 – 1754;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 5948-71-0, Ethyl 4-(4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C14H15ClN2O3, blongs to pyrimidines compound. Computed Properties of C14H15ClN2O3

3,4-Dihydropyrimidin-2(1H)-ones and iodine (1:1 mol) were taken in DMSO, and irradiated in microwave reactor at 120 C for 5 min. The completion of reaction was monitored by TLC (ethylacetate:hexane = 50:50). The brown-red colored reaction mixture was poured into saturated solution of sodium thiosulfate. The separated solid product was filtered, dried and recrystallized from methanol.

The synthetic route of 5948-71-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kodape, Manisha M.; Aswar, Anand S.; Gawhale, Nandkishor D.; Humne, Vivek T.; Mir, Bilal Ahmad; Chinese Chemical Letters; vol. 23; 12; (2012); p. 1339 – 1342;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia