59864-30-1 | Pyrimidines

Kuriwaki, Ikumi et al. published their research in Bioorganic & Medicinal Chemistry in 2020 | CAS: 59864-30-1

2,6-Dimethoxypyrimidine-4-carboxylic acid (cas: 59864-30-1) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Reference of 59864-30-1

Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2 was written by Kuriwaki, Ikumi;Kameda, Minoru;Hisamichi, Hiroyuki;Kikuchi, Shigetoshi;Iikubo, Kazuhiko;Kawamoto, Yuichiro;Moritomo, Hiroyuki;Kondoh, Yutaka;Amano, Yasushi;Tateishi, Yukihiro;Echizen, Yuka;Iwai, Yoshinori;Noda, Atsushi;Tomiyama, Hiroshi;Suzuki, Tomoyuki;Hirano, Masaaki. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Reference of 59864-30-1 This article mentions the following:

Fibroblast growth factor receptor 3 (FGFR3) is an attractive therapeutic target for the treatment of bladder cancer. We identified 1,3,5-triazine derivative 18b and pyrimidine derivative 40a as novel structures with potent and highly selective FGFR3 inhibitory activity over vascular endothelial growth factor receptor 2 (VEGFR2) using a structure-based drug design (SBDD) approach. X-ray crystal structure anal. suggests that interactions between 18b and amino acid residues located in the solvent region (Lys476 and Met488), and between 40a and Met529 located in the back pocket of FGFR3 may underlie the potent FGFR3 inhibitory activity and high kinase selectivity over VEGFR2. In the experiment, the researchers used many compounds, for example, 2,6-Dimethoxypyrimidine-4-carboxylic acid (cas: 59864-30-1Reference of 59864-30-1).

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some tips on 2,6-Dimethoxypyrimidine-4-carboxylic acid

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59864-30-1, 2,6-Dimethoxypyrimidine-4-carboxylic acid.

Electric Literature of 59864-30-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59864-30-1, name is 2,6-Dimethoxypyrimidine-4-carboxylic acid, molecular formula is C7H8N2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 43 Preparation of (S)-3-[(2,6-dimethoxy-pyrimidine-4-carbonyl)-amino]-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid (S)-3-amino-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-methyl-thiophene-2-carbonyl]-amino}-propionic acid methyl ester (HCl salt) (100 mg, 0.23 mmol) was dissolved in DMF (2.5 ml) and the following reagents were successively added at rt: 2,6-dimetoxy-pyrimidine-4-carboxylic acid (47 mg, 0.26 mmol), triethylamine (0.10 ml, 0.70 mmol), HOBT (38 mg, 0.28 mmol), and HBTU (110 mg, 0.28 mmol). The mixture was stirred at rt for 1 h, then quenched with 1N HCl and extracted with EtOAc. The layers were separated. The organic layer was successively washed with water and brine, then dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by flash chromatography with 50-100% EtOAc in hexane to afford the desired methyl ester (60 mg, 46% yield). This ester was dissolved in THF/water (2 ml/1 ml) and treated with LiOH.H2O (44 mg, 1.0 mmol) at 40 C. for 40 min. The mixture was quenched with 1N HCl and concentrated. The crude was purified by reverse phase HPLC to afford the desired product (39 mg, 72% yield). MS m/e 544.0 (M+H+).

Reference:
Patent; Gillespie, Paul; Michoud, Christophe; Rupert, Kenneth Carey; Thakkar, Kshitij Chhabilbhai; US2012/238569; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Extended knowledge of 2,6-Dimethoxypyrimidine-4-carboxylic acid

Synthetic Route of 59864-30-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59864-30-1, name is 2,6-Dimethoxypyrimidine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 39b (278 mg, 0.47 mmol) in DMF (5.0 mL) wereadded 4,6-dimethoxypyrimidine-2-carboxylic acid (103 mg,0.56 mmol), DIPEA (160 muL, 0.93 mmol) and HATU (236 mg,0.62 mmol) in an ice-water bath. After stirring at room temperatureovernight, the mixture was quenched with NaHCO3 aq. and extractedwith CHCl3. The organic layer was washed with brine, dried overMgSO4 and concentrated in vacuo. The residue was purified by columnchromatography on silica gel (CHCl3/MeOH/28% NH3 aq.=100:0:0 to90:9:1). EtOAc/IPE was added to the residue, and the resulting precipitatewas filtered and dried. To the precipitate was added EtOH/EtOAc/MeCN, and the mixture was heated to 100 C. After cooling toroom temperature, the resulting precipitate was filtered and dried togive the product (96 mg, 27%) as a colorless solid. 1H NMR (DMSO-d6):delta 0.90 (3H, t, J = 7.2 Hz), 1.46-1.61 (2H, m), 1.74-1.86 (2H, m), 2.14(3H, s), 2.20-2.58 (11H, m), 2.74-2.85 (2H, m), 3.25-3.39 (2H, m),3.67 (3H, s), 4.03 (6H, s), 6.48 (1H, s), 6.82 (1H, d, J = 8.4 Hz),7.16-7.29 (3H, m), 7.51-7.62 (2H, m), 7.77 (1H, dd, J = 7.9, 1.5 Hz),8.13 (1H, s), 8.74-8.87 (1H, m), 9.14 (1H, br s), 9.27 (1H, s), 10.14(1H, br s); MS (ESI) m/z [M+H]+ 762; Anal. Calcd forC36H47N11O6S·1.7H2O: C, 54.56; H, 6.41; N, 19.44; S, 4.05. Found: C,54.55; H, 6.38; N, 19.45; S, 4.02.

Reference:
Article; Amano, Yasushi; Echizen, Yuka; Hirano, Masaaki; Hisamichi, Hiroyuki; Iikubo, Kazuhiko; Iwai, Yoshinori; Kameda, Minoru; Kawamoto, Yuichiro; Kikuchi, Shigetoshi; Kondoh, Yutaka; Kuriwaki, Ikumi; Moritomo, Hiroyuki; Noda, Atsushi; Suzuki, Tomoyuki; Tateishi, Yukihiro; Tomiyama, Hiroshi; Bioorganic and medicinal chemistry; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia