Category: 5993-98-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5993-98-6, name is 4-Chloro-2-methyl-6-(trifluoromethyl)pyrimidine. A new synthetic method of this compound is introduced below., Computed Properties of C6H4ClF3N2

General procedure: 1 mmol of compound 5, 2 mmol of NaH and 8.8 mmol of 2-34′ or metadienyl heterocycle were dissolved in 10 mL of anhydrous tetrahydrofuran, and the reaction was heated to reflux. TLC followed the test. The disappearance of the starting material stopped the reaction. Silica gel column chromatography ((VMi/Vssi=1/50) gives compounds A1 to A7. The structure of the 2-halo or sulfone-based heterocycle is shown in Table 1 below.

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Reference:
Patent; Central China Normal University; Yang Guangfu; Li Jun; (22 pag.)CN104974083; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5993-98-6, name is 4-Chloro-2-methyl-6-(trifluoromethyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Chloro-2-methyl-6-(trifluoromethyl)pyrimidine

To benzyl (7S)-7-methyl-5-(2-(1,3-thiazol-2-yl)benzoyl)-1,2,5-oxadiazepane-2-carboxylate (88 mg) obtained in Step A of Example 84 was added 5.1M hydrogen bromide acetic acid solution (2.0 mL), and the mixture was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and a mixture of the residue, ethanol (2.0 mL), acetic acid (0.012 mL) and 4-chloro-2-methyl-6-trifluoromethylpyrimidine (43.5 mg) was stirred in a microwave reactor at 150 C. for 0.5 hr. To the reaction mixture was added saturated aqueous sodium hydrogencarbonate solution, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed successively with water and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (NH, hexane/ethyl acetate), and crystallized (hexane/diisopropyl ether) to give the title compound (45 mg). MS: [M+H]+ 464.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5993-98-6, 4-Chloro-2-methyl-6-(trifluoromethyl)pyrimidine.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KAMEI, Taku; ARIKAWA, Yasuyoshi; OHASHI, Tomohiro; IMAEDA, Toshihiro; FUJIMORI, Ikuo; MIKI, Takashi; YONEMORI, Jinichi; OGURO, Yuya; SUGIMOTO, Takahiro; SETO, Masaki; NISHIDA, Goushi; KAMATA, Makoto; IMOTO, Hiroshi; (132 pag.)US2018/155333; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia