Category: 59989-18-3

Electric Literature of 59989-18-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59989-18-3, name is 5-Ethynylpyrimidine-2,4(1H,3H)-dione, molecular formula is C6H4N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under argon, cuprous iodide (0.02 mmol, 3.8 mg) and tetraphenylphosphine were used Palladium (0.02 mmol, 23 mg) and 1-octane, 5-ethynyluracil. 4 mmol, 99.6 mg) were added successively to a solution of 4,4-dodecylalkynyl-2,6- (0.2 mmol, 225.8 mg). Triethylamine (5 mL) was injected into the above mixture with a syringe and incubated in an oil bath at 60 C In response to four hours. Thin layer chromatography, until the reaction is complete, the reaction is also added 20mL water quenching reaction. The product was extracted with ether (3 x 40 mL) and the organic phase was washed three times with water (3 x 40 mL). Anhydrous magnesium sulfate drying, vacuum distillation solvent. The crude product was separated and purified by column chromatography, and the eluent was dichloromethane: ethyl acetate = 10: 1, volume ratio. The product was recrystallized from n-pentane as a purple-red solid, 199 mg in 60% yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59989-18-3, 5-Ethynylpyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; Tianjin University; Chen Zhijian; Liu Ping; (17 pag.)CN107056829; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 59989-18-3 ,Some common heterocyclic compound, 59989-18-3, molecular formula is C6H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 8 2′-Deoxy-5-ethynyl-4′-thiouridine Starting with 5-ethynyluracil, this compound was prepared in a similar manner to that described in Example 5. 5ethynyluracil may be prepared from 5-ioduracil using the methodology analogous to that described by M. J. Robins et al (ibid). A sample of the pure beta-anomer of this compound was obtained by boiling the crude anomer mixture with MeOH and filtering off the product. 1 H-200 MHz NMR DMSO-d6 delta:11.6 (br s, 1H, NH); 8.42 (s, 1H, beta-6-H); 6.23(t, 1H, beta-1′-H); 5.1-5.35 (m, 2H, beta-3’+5′-OH); 4.25-4.45 (m, 1H, beta-3′-H); 4.15 (s, 1H CH); 3.55-3.75 (m,2H, beta-5′-H); 3.1-3.5 (beta-4’H, obscured by DOH); 2.1-2.4 (m,2H, beta-5′-H2). Mass spectrum: observed m/z 268 for C11 H11 N2 O4 S.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,59989-18-3, its application will become more common.

Reference:
Patent; University of Birmingham; US5356882; (1994); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 59989-18-3 as follows., 59989-18-3

under protection of argon, the cuprous iodide (0.02 mmol, 3.8 mg), four-triphenylphosphine palladium (0.02 mmol, 23 mg) and 1 – octane, 5 – ethynyl uracil (0.4 mmol, 99.6 mg) are added to the 4, 4 – di (3, 4, 5 – c (dodecyl) benzyl alkyne base) – 2, 6 – diiodosalicylic -8 – (3, 4, 5 – c (dodecyl) phenyl) beryllium two pyrrole in (0.2 mmol, 480 mg). For syringe triethylamine (5 ml) is injected into the mixture and, in the 70 C reaction in oil bath for four hours. Thin layer chromatographic detection, to be the reaction is complete, the reaction also adding 20 ml water quenching reaction. Ethyl ether (3 ¡Á 40 ml) extraction product, organic phase water (3 ¡Á 40 ml) washing three times. Anhydrous magnesium sulfate drying, pressure reducing and steaming and in addition to the solvent. The crude product column chromatographic separation and purification, showering liquid to dichloromethane: ethyl acetate=50:1, volume ratio. The product methanol recrystallization is purple solid, 179.5 mg, yield is 68%.

The chemical industry reduces the impact on the environment during synthesis 59989-18-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Tianjin University; Chen Zhijian; Liu Ping; (17 pag.)CN107056829; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia