Category: 60025-09-4

Adding a certain compound to certain chemical reactions, such as: 60025-09-4, 4-Amino-6-chloropyrimidine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H3ClN4, blongs to pyrimidines compound. Computed Properties of C5H3ClN4

e) (S)-4-Amino-6-(2-(5-(methylsulfonyl)-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yI)pyrrolidin-1 -yI)pyrimidine-5-carbonitrileA solution of (S)-5-(methylsu lfonyl)-3-phenyl-2-(pyrrolid in-2-yl)quinazolin-4(3H)-one (38 mg,0.10 mmol) and 4-amino-6-chloropyrimidine-5-carbonitrile (CAS registry 60025-09-4) (15.9mg, 0.10 mmol) in EtCH (1 ml) was treated with DIPEA (0.045 ml, 0.26 mmol) and wasstirred at 120C for 45 mm in mw. The reaction mixture was evaporated under reducedpressure. The oil was taken up in DCM and washed with sat. aq. NHCO3soln., the organic layer was dried over Na2SO4 and concentrated in vacuo. The crude was purified over SFC (column PPU, 250 x30 mm, 60A, 5pm, Princeton, flow at 100 mI/mm; gradient of MeCH in supercritical CC2, from 18 % to 23 % in ii mm) to afford the title compound as a beige solid(33 mg, 63 % yield).HPLC RtM2=0.87 mm; ESIMS: 488 [(M+H)].1H NMR (400 MHz, DMSC-d6): O 8.24 (dd, 1 H), 7.85-8.05 (m, 3 H), 7.50-7.70 (m, 5 H),7.24 (br s, 2 H), 4.50 – 4.75 (m, 1 H), 3.99 – 4.16 (m, 1 H), 3.80 – 3.97 (m, 1 H), 3.48 (5, 3 H),2.18 -2.31 (m, 1 H), 2.05 -2.18 (m, 1 H), 1.78- 2.03 (m, 2 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60025-09-4, 4-Amino-6-chloropyrimidine-5-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; GUIBOURDENCHE, Christel; HINTERMANN, Samuel; HURTH, Konstanze; JACQUIER, Sebastien; KALIS, Christoph; MOEBITZ, Henrik; SOLDERMANN, Nicolas; WO2014/128612; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 60025-09-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 60025-09-4, name is 4-Amino-6-chloropyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below.

N-[3-Amino-1 -(6-amino-5-cvano-pyrimidin-4-yl)-pyrrolidin-3-ylmethyl1-2,4-difluoro- benzamide (“196”)A mixture of 4-amino-6-chloropyrimidine-5-carbonitrile (72.0 mg; 0.47 mmol; 1 .02 eq.), N-[(3-aminopyrrolidin-3-yl)methyl]-2,4-difluorobenzamide dihydrochloride (150.0 mg; 0.46 mmol; 1 .0 eq.), potassium carbonate (126.3 mg; 0.91 mmol; 2.0 eq.) in DMSO (2.00 ml) was stirred at 60 C for 2h. The reaction mixture was workup and the crude was purified by reverse phase pre-HPLC (Waters, acetonitrile/0.1 % NH40H in water) to afford the title compound in 70% yield. LC-MS: (M+1 =374, obsd. = 374).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60025-09-4, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; LAN, Rouxi; HUCK, Bayard R.; CHEN, Xiaoling; DESELM, Lizbeth Celeste; XIAO, Yufang; QIU, Hui; NEAGU, Constantin; MOCHALKIN, Igor; JOHNSON, Theresa L.; WO2013/40044; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 60025-09-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 60025-09-4 as follows.

To a stirred solution of 1-(3-(pyridin-2-yl)-1,6-naphthyridin-2-yl)ethanamine (15 mg, 0.060 mmol) in butanol (1.5 mL) was added 4-amino-6-chloropyrimidine-5-carbonitrile (9.26 mg, 0.060 mmol) and N-ethyl-N-isopropylpropan-2-amine (20.93 muL, 0.120 mmol). The reaction was heated at 120 C. for 2 h. After this time the reaction was cooled to rt. The resulting precipitate was filtered and washed with hexanes to give racemic 4-amino-6-(((1S,1R)-1-(3-(2-pyridinyl)-1,6-naphthyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile. 1H NMR (400 MHz, chloroform-d) delta ppm 9.33 (1H, s), 8.83 (2H, d, J=5.9 Hz), 8.33 (1H, s), 8.14 (1H, s), 8.02 (1H, d, J=5.9 Hz), 7.93 (1H, td, J=7.7, 1.8 Hz), 7.64 (2H, d, J=7.8 Hz), 7.44 (1H, ddd, J=7.6, 4.9, 1.0 Hz), 6.15 (1H, m), 5.28 (2H, bs), 1.38-1.43 (3H, m). Mass Spectrum (ESI) m/e=251.0. Mass Spectrum (ESI) m/e=369.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60025-09-4, its application will become more common.

Reference:
Patent; AMGEN INC.; US2010/331306; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 60025-09-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60025-09-4, name is 4-Amino-6-chloropyrimidine-5-carbonitrile, molecular formula is C5H3ClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of 7a (80mg, 0.18mmol, 1 equiv), 4-amino-6-chloropyrimidine-5-carbonitrile (31mg, 0.2mmol, 1.1 equiv) in BuOH was added DIPEA (0.06mL, 0.36mmol, 2 equiv). The mixture was reacted under microwave at 130C for 20min. After completion, the solvent was removed under reduced pressure. The residue was redissolved in CH2Cl2. The crude was further purified via silica gel chromatography to give compound 8a as white solid (81mg, 80%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60025-09-4, 4-Amino-6-chloropyrimidine-5-carbonitrile.

Reference:
Article; Wei, Manman; Zhang, Xi; Wang, Xiang; Song, Zilan; Ding, Jian; Meng, Ling-Hua; Zhang, Ao; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 1156 – 1171;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 60025-09-4, 4-Amino-6-chloropyrimidine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4-Amino-6-chloropyrimidine-5-carbonitrile, blongs to pyrimidines compound. Recommanded Product: 4-Amino-6-chloropyrimidine-5-carbonitrile

24.89 kg of tetrahydrofuran was added to a 100 L reaction kettle, and stirring was started, followed by the addition of 2.84 kg of (S)-3-(1-aminoethyl)-8-chloro-2-phenylquinolin-4(1H)-one and 1.34. Kg 4-amino-5-cyano-6-chloropyrimidine, heated to 65 ¡À 5 C, then add 4.22 kg of cesium carbonate, continue to reflux for 1 to 1.5 hours, HPLC to monitor the reaction to the end; 7.10 kg of acetone was washed, the solvent was removed from the filtrate, and 20 kg of purified water was added thereto for stirring for 1 to 2 hours, and the mixture was centrifuged, and purified water was washed twice. The obtained solid was air-dried at 70 ¡À 5 C for 10 hours or more to obtain 3.55 kg of the title compound.3.55 kg of the above crude product was added to 43.34 kg of acetone at room temperature, stirred until it was dissolved, filtered, and the filtrate was added to a 100 L reaction vessel, heated to reflux, and some acetone was distilled off until the residue in the kettle was slightly turbid, and the mixture was slowly added dropwise. Kg of methanol, after the completion of the addition, naturally reduce to room temperature, then cool to 5 ¡À 5 C, heat crystallization for more than 1 hour, filtration, filter cake with a mixture of 0.78 kg weight ratio of acetone / methanol = 1/2, the resulting The solid was vacuum dried at 60 ¡À 5 C for more than 12 hours to obtain 2.23 kg of (S)-4-amino-6-((1-(8-chloro-4-oxo-2-phenyl-1,4-di) Hydroquinolin-3-yl)ethyl)amino)pyrimidine-5-cyano, yield 62.0%.

The synthetic route of 60025-09-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Zhao Liwen; Sha Xiangyang; Ye Shichun; Ding Zhaobing; Chen Cheng; Li Linyi; (19 pag.)CN109516975; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60025-09-4, name is 4-Amino-6-chloropyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 60025-09-4

To a solution of (S)-6-amino-1′,8-dimethyl-2H-spiro[imidazo[1,5-a]pyridine-3,3′-piperidine]-1,5-dione (6B, 2.0 g, 7.6 mmol) in tert-butanol (30 mL) were added 4-amino-6-chloropyrimidine-5-carbonitrile (7, 1.17 g, 7.6 mmol) and p-toluenesulfonic acid (1.30 g, 7.6 mmol). The reaction mixture was heated at 120 C. for 15 h in a sealed tube. Then the reaction mixture was concentrated and the residue was dissolved in 20% isopropanol/chloroform (100 mL). The organic layer was washed with a solution of saturated sodium bicarbonate solution, dried over sodium sulphate, filtered and concentrated. The residue was purified with silica gel column chromatography using combiflash (5-7% methanol in dichloromethane) to afford (S)-4-amino-6-((1′,8-dimethyl-1,5-dioxo-1,5-dihydro-2H-spiro[imidazo[1,5-a]pyridine-3,3′-piperidin]-6-yl)amino)pyrimidine-5-carbonitrile (Cpd. No. 2Fb) as a white solid. Yield: 0.49 g, 18%. MS (ESI) m/z 381.17[M+1]+; ee=95.58%, Rt=8.89 min, Chiralpak IC (4.6*250 mm, 5 mum) using an isocratic gradient of methanol/carbon dioxide (40:60).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 60025-09-4, 4-Amino-6-chloropyrimidine-5-carbonitrile.

Reference:
Patent; eFFECTOR Therapeutics, Inc.; ERNST, Justin T.; SPRENGELER, Paul A.; REICH, Siegfried H.; SPERRY, Samuel; US2018/228803; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 60025-09-4, name is 4-Amino-6-chloropyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. 60025-09-4

4- Amino-6-(((lS, lR)-l-(3-(2-pyridinyl)-l,6-naphthyridin-2-yl)ethyl)amino)-5- pyrimidinecarbonitrile; To a stirred solution of l-(3-(pyridin-2-yl)-l,6-naphthyridin-2-yl)ethanamine (15 mg, 0.060 mmol) in butanol (1.5 mL) was added 4-amino-6-chloropyrimidine-5- carbonitrile (9.26 mg, 0.060 mmol) and N-ethyl-N-isopropylpropan-2-amine (20.9 uL, 0.120 mmol). The reaction was heated at 120 C for 2 h. After this time the reaction was cooled to r.t. The resulting precipitate was filtered and washed with hexanes to give racemic 4-amino-6-(((lS, lR)-l-(3-(2-pyridinyl)-l,6- naphthyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 9.33 (1 H, s), 8.83 (2 H, d, J=5.9 Hz), 8.33 (1 H, s), 8.14 (1 H, s), 8.02 (1 H, d, J=5.9 Hz), 7.93 (1 H, td, J=7.7, 1.8 Hz), 7.64 (2 H, d, J=7.8 Hz), 7.44 (1 H, ddd, J=7.6, 4.9, 1.0 Hz), 6.15 (1H, m), 5.28 (2 H, bs), 1.38 – 1.43 (3 H, m). Mass Spectrum (ESI) m/e = 251.0. Mass Spectrum (ESI) m/e = 369.2 (M+l).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60025-09-4, 4-Amino-6-chloropyrimidine-5-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; AMGEN INC.; CHEN, Yi; CUSHING, Timothy, D.; FISHER, Benjamin; GONZALEZ LOPEZ DE TURISO, Felix; HAO, Xiaolin; SHIN, Youngsook; WO2012/87784; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia