In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60561-50-4, name is Methyl 2-(2-Pyrimidyl)acetate, the common compound, a new synthetic route is introduced below. SDS of cas: 60561-50-4
Step A: Methyl pyrrolo[1,2-a]pyrimidine-8-carboxylate (0122) To a solution of 6.2 g of methyl 2-pyrimidin-2-ylacetate (40.75 mmol) in 250 mL of acetone there are successively added 14.04 g (167 mmol) of NaHCO3 in the form of a powder, 13.2 mL (203.75 mmol) of chloroacetaldehyde and then 3.54 g (40.75 mmol) of lithium bromide. The batch is heated at 60 C. for 24 hours. The reaction mixture is then concentrated to dryness, taken up in ethyl acetate, washed with water, dried over MgSO4, filtered and then concentrated to dryness. The solid thereby obtained is then purified by chromatography over silica gel (AcOEt). The expected product is obtained in the form of an oil. (0123) Mass spectrum: (0124) Empirical formula: C8H8N2O2 (0125) LC/MS: m/z=[M+H]+=177
The synthetic route of 60561-50-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LES LABORATOIRES SERVIER; VERNALS (R&D) LIMITED; Le Tiran, Arnaud; Le Diguarher, Thierry; STARCK, Jerome-Benoit; Henlin, Jean-Michel; De Nanteuil, Guillaume; GENESTE, Olivier; Davidson, James Edward Paul; Murray, James Brooke; Chen, I-Jen; (36 pag.)US2016/176848; (2016); A1;,
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