Category: 607740-08-9

Synthetic Route of 607740-08-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 607740-08-9, name is 4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

In the argon atmosphere,Intermediate A (4.4 g, 21 mmol) synthesized according to the method described in JP-A-2010-180204,Intermediate B (4.7 g, 10 mmol) according to the method described in International Publication No. 2003/080760,(Dibenzylideneacetone) dipalladium (0.37 g, 0.4 mmol)Tri-butyl-tetrafluoroborate (0.46 g, 1.6 mmol)Sodium butoxide (2.7 g, 28 mmol)Anhydrous toluene (100 mL),And heated to reflux for 8 hours.After the reaction solution was allowed to cool to room temperature,Separating the organic layer,The organic solvent was distilled off under reduced pressure.The resulting residue was purified by silica gel column chromatography,The title compound GH-4 (3.6 g, yield 50%) was obtained.

According to the analysis of related databases, 607740-08-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; Ogiwara, Toshinari; Hosokawa, Chishio; (82 pag.)TW2016/38086; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 607740-08-9 , The common heterocyclic compound, 607740-08-9, name is 4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H14Br2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Under a nitrogen stream3,6-bis (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -9-phenylcarbazole 10.0 gmmol),4- (3,5-Dibromo-phenyl) -2,6-diphenyl-pyrimidine 9.41 g (20.19 mmol) K2CO3 16.7 g,800 ml of toluene,Then, 200 ml of a mixed solution was put into a 2-liter 2-neck round bottom flask, stirred for 30 minutes at room temperature,Pd (PPh3) 4 (70 mg, 0.61 mmol) was added thereto and refluxed for 18 hours.After the reaction was completed, the reaction mixture was extracted with methylene chloride, added with MgSO 4 and filtered.After removal of the solvent of the obtained organic layer, the residue was purified by column chromatography to obtain the target compound Macrocycle-II (4.93 g, yield 22.3%).

The synthetic route of 607740-08-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Doosan Co., Ltd; Um Min-sik; Kim Tae-hyeong; Baek Yeong-mi; (20 pag.)KR101847236; (2018); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 607740-08-9, name is 4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

In the argon atmosphere, Intermediate A (4.4 g, 21 mmol) synthesized according to the method described in JP-A-2010180204, Intermediate B (4.7 g, 10 mmol) synthesized according to the method described in International Publication No. 2003/080760, (Dibenzylideneacetone) dipalladium (0.37 g, 0.4 mmol) Tri-t-butylphosphonium tetrafluoroborate (0.46 g, 1.6 mmol)Sodium t-butoxide (2.7 g, 28 mmol) Anhydrous toluene (100 mL), And heated to reflux for 8 hours. After the reaction solution was allowed to cool to room temperature, Separating the organic layer, The organic solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography, The title compound GH-4 (3.6 g, yield 50%) was obtained.

With the rapid development of chemical substances, we look forward to future research findings about 607740-08-9.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; KAWAMURA, MASAHIRO; ITO, HIROKATSU; OGIWARA, TOSHINARI; MIZUKI, YUMIKO; (145 pag.)TWI554499; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 607740-08-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 607740-08-9, name is 4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H14Br2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(3) Synthesis of Compound (A98)Intermediate Compound (K) in an amount of 3.0 g (6 mmoles), 2.3 g (14 mmoles) of carbazole, 0.12 g (0.6 mmoles) of copper iodide and 4.2 g (20 mmoles) of potassium phosphate were suspended into 21 ml of 1,4-dioxane. To the obtained suspension, 0.8 ml (6 mmoles) of trans-1,2-cyclohexanediamine was added. Under the atmosphere of argon, the resultant mixture was heated for 18 hours under the refluxing condition. The reaction solution was then cooled at the room temperature. Methylene chloride and water were added and the resultant mixture was separated into two layers. The organic layer was washed with water and dried with anhydrous sodium sulfate. After the organic solvent was removed by distillation under a reduced pressure, the residue of distillation was suspended into 21 ml of dioxane. To the obtained suspension, 0.12 g (0.6 mmoles) of copper iodide, 2.9 g (14 mmoles) of potassium phosphate and 0.8 ml (6 mmoles) of trans-1,2-cyclohexanediamine were added. Under the atmosphere of argon, the resultant mixture was heated for 18 hours under the refluxing condition. The reaction solution was then cooled at the room temperature. Methylene chloride and water were added and the resultant mixture was separated into two layers. The organic layer was washed with water and dried with anhydrous sodium sulfate. After the organic solvent was removed by distillation under a reduced pressure, 30 ml of ethyl acetate was added. The formed crystals were separated by filtration and washed with ethyl acetate and 3.3 g (the yield: 80%) of yellowish white crystals were obtained. It was confirmed by 90 MHz 1H-NMR and FD-MS that the obtained crystals were the target substance (A98). The result of the measurement by FD-MS is shown in the following:FD-MS calcd. for C46H30N4=638; found: m/z=638 (M+, 100)

According to the analysis of related databases, 607740-08-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; US2012/319099; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia