Category: 611-08-5

611-08-5, Adding a certain compound to certain chemical reactions, such as: 611-08-5, 5-Nitrouracil, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 611-08-5, blongs to pyrimidines compound.

Example 15-aminopyrimidine-2,4(1H,3H)-dione 1 Into a 5-L 4-necked round-bottom flask were placed water (2.871 L), ammonia (116.1 mL) and 5-nitropyrimidine-2,4(1H,3H)-dione (180 g, 1.15 mol, 1.00 equiv). This was followed by the addition of Na2S2O2 (860 g, 6.06 mol, 4.30 equiv) in several batches. The pH value of the solution was adjusted to 8 with ammonia (25%). The resulting solution was stirred for 3 h (hours) at 75 C. The reaction mixture was cooled to 15 C. with an ice/water bath. The solid was collected by filtration. This resulted in 118 g (81%) of 5-aminopyrimidine-2,4(1H,3H)-dione 1 as a yellow solid (see Scheme 1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,611-08-5, its application will become more common.

Reference:
Patent; Castanedo, Georgette; Chan, Bryan; Lucas, Matthew C.; Safina, Brian; Sutherlin, Daniel P.; Sweeney, Zachary; US2011/207713; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

611-08-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 611-08-5, name is 5-Nitrouracil, molecular formula is C4H3N3O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 2′,3′,5′-tri-O-Benzoyl-5-fluorouridine (3a)S1 (Table 2, entry 1). A mixture of5-fluorouracil (51.1 mg, 0.39 mmol), pyridine (0.6 mL), and hexamethyldisilazane(HMDS) (1.2 mL) was refluxed for ca. 40 min to give a clear solution of 2a. All thevolatiles were then removed under reduced pressure (ca. 1 mmHg) to give a clear syrup,which was dissolved in acetone (3.0 mL). To this were added1-O-acetyl-2,3,5-tri-O-benzoyl–D-ribofuranose (1) (151.8 mg, 0.30 mmol) and 7b (4.5mg, 0.015 mmol, 5 mol%) and the mixture was stirred under reflux for 6 h. After themixture was cooled to rt, it was diluted with EtOAc (2 mL), followed by the addition ofa saturated NaHCO3 aq (2 mL) at 0 C. After the mixture was stirred at 0 oC for 15min, EtOAc (30 mL) and a saturated NaHCO3 aq (20 mL) were added. The organicphase was separated and the aqueous phase was back-extracted with EtOAc (30 mL x 3).The combined organic layers were dried with Na2SO4 and evaporated to afford a crudematerial, which was purified by recrystallization from EtOAc (5 mL) and hexane (7mL) to afford 2′,3′,5′-tri-O-benzoyl-5-fluorouridine (3a) (152 mg, 88%) as a whitepowder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 611-08-5, 5-Nitrouracil, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Shirouzu, Hiroshi; Morita, Hiroki; Tsukamoto, Masaki; Tetrahedron; vol. 70; 22; (2014); p. 3635 – 3639;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

611-08-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 611-08-5, name is 5-Nitrouracil. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a round-bottom flask (50 mL) was added a mixture of the desired nucleobases or other N-heterocycles (1 mmol), CSSNH (0.05 g), and HMDS (10 mL). The reaction mixture was heated at 90 C until a clear liquid was attained (Table 3). Subsequently, the catalyst was filtered and the filtrate was then evaporated using vacuum to separate the crude silylated product from HMDS. The crude product was pure enough to be applied in the next step without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 611-08-5, 5-Nitrouracil.

Reference:
Article; Behrouz, Somayeh; Soltani Rad, Mohammad Navid; Piltan, Mohammad Amin; Chemical Papers; vol. 74; 1; (2020); p. 113 – 124;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

611-08-5 , The common heterocyclic compound, 611-08-5, name is 5-Nitrouracil, molecular formula is C4H3N3O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A suspension of 5-nitrouracil (10 g, 63 mmol) in POCl3 (100 mL) was refluxed for 5 h in the presence of N,N-dimethylaniline (10 mL), cooled to room temperature and poured on to crushed ice with vigorous stirring. The aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over MgSO4 and the solvent was evaporated under reduce pressure. The residue was purified by chromatography on silica gel (hexane/ethyl acetate; 1/1; v/v) to give the desired 2,4-dichloro-5-nitropyrimidine. LCMS: ret. time: 23.26 min.; purity: 95percent; 1H NMR (CDCl3): delta 9.16 (1H, s).

According to the analysis of related databases, 611-08-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; Singh, Rajinder; Argade, Ankush; Payan, Donald; Molineaux, Susan; Holland, Sacha; Clough, Jeffrey; Keim, Holger; Bhamidipati, Somasekhar; Sylvain, Catherine; Li, Hui; Rossi, Alexander; US2015/266828; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

611-08-5 , The common heterocyclic compound, 611-08-5, name is 5-Nitrouracil, molecular formula is C4H3N3O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation of 2,4-dichloro-5-nitropyrimidine. 5-Nitrouracil, was treated with phosphorous oxychloride and N, N- [DIMETHYLANILINE,] according to the procedure of Whittaker (J. Chem. Soc. 1951,1565), to give the title compound, which is also available from City Chemical (West Haven, CT).

According to the analysis of related databases, 611-08-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2003/99231; (2003); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia