A new synthetic route of 61727-33-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,61727-33-1, its application will become more common.

Related Products of 61727-33-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 61727-33-1 as follows.

(0234) To a solution of 5-chloro-2-(methylthio)pyrimidine-4-carboxylic acid (1.026 g, 5.02 mmol) in 1:1 DCM:methanol was added a solution of trimethylsilyldiazomethane (2M/hexanes, 1.6 mL, 3.2 mmol). The reaction was stirred at RT for 30 min and then concentrated to give the desired 29-1, which was used without further purification. MS (ESI): mass calcd. for C7H7ClN2O2S, 218.0; m/z found 219.1 [M]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,61727-33-1, its application will become more common.

Reference:
Patent; Sunesis Pharmaceuticals, Inc.; HANSEN, Stig; ERLANSON, Dan; CANCILLA, Mark; EP2257637; (2015); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

New learning discoveries about 61727-33-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 61727-33-1, 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 61727-33-1, Adding some certain compound to certain chemical reactions, such as: 61727-33-1, name is 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid,molecular formula is C6H5ClN2O2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61727-33-1.

A mixture of 780 mg of 2-(difluoromethoxy)benzaldehyde and 300 mg of 5-chloro-2- (methylsulfanyl)pyrimidine-4-carboxylic acid 1 in 15 ml of anisole is microwave-heated at 130C for 45 min and then again for 15 min and again at 140C for 15 min. 160 mg of 5-chloro-2-(methylsulfanyl)pyrimidine-4-carboxylic acid 1 is then added and the mixture is again heated at 130C for 30 min. The mixture is concentrated under vacuum and purified on 40 g of silica, elution being carried out with 0-10% of ethyl acetate in heptane, so as to obtain 268 mg of [5-chloro-2-(methylsulfanyl)pyrimidin-4-yl][2- (difluoromethoxy)phenyl]methanol 6 in the form of a colourless oil

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 61727-33-1, 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SANOFI; CARRY, Jean-Christophe; CHATREAUX, Fabienne; DEPRETS, Stephanie; DUCLOS, Olivier; LEROY, Vincent; MALLART, Sergio; MELON-MANGUER, Dominique; MENDEZ-PEREZ, Maria; VERGNE, Fabrice; WO2013/150036; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Introduction of a new synthetic route about 61727-33-1

According to the analysis of related databases, 61727-33-1, the application of this compound in the production field has become more and more popular.

Related Products of 61727-33-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 61727-33-1, name is 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

(a) 5-Chloro-2-methylthio-4-pyrimidine carboxylic acid (30 g) was heated at 180-200 C. until all the solid had melted and the evolution of carbon dioxide had ceased (5 min). The residue was allowed to cool and then washed with several portions of chloroform. The chloroform washings were filtered to remove dark insoluble material and the filtrate was concentrated to give 5-chloro-2-methylthiopyrimidine as a pale brown crystalline solid (21 g, 89%), m.p. 55 C.

According to the analysis of related databases, 61727-33-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ICI Australia Limited; US4248618; (1981); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Extracurricular laboratory: Synthetic route of 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 61727-33-1, 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 61727-33-1, name is 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

Example 5 Methyl 7-[2-(difluoromethoxy)phenyl]-2-(methylsulfanyl)thieno[3,2-d]pyrimidine-6-carboxylate A mixture of 780 mg of 2-(difluoromethoxy)benzaldehyde and 300 mg of 5-chloro-2-(methylsulfanyl)pyrimidine-4-carboxylic acid 1 in 15 ml of anisole is microwave-heated at 130 C. for 45 min and then again for 15 min and again at 140 C. for 15 min. 160 mg of 5-chloro-2-(methylsulfanyl)pyrimidine-4-carboxylic acid 1 is then added and the mixture is again heated at 130 C. for 30 min. The mixture is concentrated under vacuum and purified on 40 g of silica, elution being carried out with 0-10% of ethyl acetate in heptane, so as to obtain 268 mg of [5-chloro-2-(methylsulfanyl)pyrimidin-4-yl][2-(difluoromethoxy)phenyl]methanol 6 in the form of a colourless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 61727-33-1, 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid.

Reference:
Patent; SANOFI; CARRY, Jean-Christophe; CHATREAUX, Fabienne; DEPRETS, Stephanie; DUCLOS, Olivier; LEROY, Vincent; MALLART, Sergio; MELON-MANGUER, Dominique; MENDEZ-PEREZ, Maria; VERGNE, Fabrice; US2013/261106; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Some scientific research about 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

According to the analysis of related databases, 61727-33-1, the application of this compound in the production field has become more and more popular.

Reference of 61727-33-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61727-33-1, name is 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid, molecular formula is C6H5ClN2O2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation Example 2: Preparation of 5-chloro-2-methanesulfonyl- pyrimidine-4-carboxylic acid methyl ester; Step 1) Preparation of 5-chloro-2-methylsulfanyl-pyrimidine-4-carboxylic acid methyl ester; 5-chloro-2-methylsulfanyl-pyrimidine-4-carboxylic acid (2.04 g, 10 mmol) was added to methanol, and 10 m? of thionyl chloride was slowly added thereto, followed by stirring the mixture for 5 hours. The resulting mixture was concentrated under a reduced pressure to remove the solvent, and sequentially washed with sodium bicarbonate solution and salt solution. The resulting residue was subjected to silica gel column chromatography (eluent: n- hexane/ethyl acetate=5:l) to obtain the title compound (2.1 g; yield: 95 %).

According to the analysis of related databases, 61727-33-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CRYSTALGENOMICS, INC.; WO2007/73117; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia