Category: 6214-47-7

Application of 6214-47-7 ,Some common heterocyclic compound, 6214-47-7, molecular formula is C8H9ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A solution of compound 7 in ethanol was added to liquidammonia in an autoclave (250 cm3) at -50 C. The mixture was heated to 60-70 C, the pressure increased to15-16 bar. It was stirred for 2 days under these conditions.The volatile components were removed and the residuewas suspended in water, filtered, and dried.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6214-47-7, its application will become more common.

Reference:
Article; Kokai, Eszter; Nagy, Jozsef; Toth, Tuende; Kupai, Jozsef; Huszthy, Peter; Simig, Gyula; Volk, Balazs; Monatshefte fur Chemie; vol. 147; 4; (2016); p. 767 – 773;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 6214-47-7, Adding some certain compound to certain chemical reactions, such as: 6214-47-7, name is Ethyl 2-(4-chloropyrimidin-5-yl)acetate,molecular formula is C8H9ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6214-47-7.

To a nitrogen de-gassed solution of ethyl 2-(4-chloropyrimidin-5-yi)acetate {1108) (0.823 g, 4.10 mmol) in dry DMF (15 mL) were added triethylamine (1.715 mL, 12.31 mmoi) followed by triphenylphosphine (0.124 g, 0.473 mmol), trans- dichlorobis(triphenyl-phosphine)pailadium(ll) (0.144 g, 0.205 mmoi), Cu(l)l (0,078 g, 0.410 mmol) and finally (triethyisilyi)acetylene (1.470 mL, 8.204 mmol). The reaction mixture was then heated under microwave irradiation at 120 C for 25 minutes, concentrated in vacuo and purified by silica gel chromatography (isoiera Biofage, 40 g Si cartridge, 0-30% EtOAc in petroleum benzine 40-60 C) to give the title compound (1109) (1.176 g, 94% yield) as a yellow-orange oil; 1H NMR (400 MHz, CDCI3) delta 9.08 (s, 1 H), 8.68 (s, 1 H), 4.18 (q, J = 7.1 Hz, 2H), 3.80 (s, 2H), 1.26 (t, J = 7.1 Hz, 3H), 1.10 – 1.01 (m, 9H), 0.77 – 0.67 (m, 6H) LCMS Method C: rt 6.64 min; m/z 305.1 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6214-47-7, Ethyl 2-(4-chloropyrimidin-5-yl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CANCER THERAPEUTICS CRC PTY LTD; DEVLIN, Mark Graeme; STREET, Ian Philip; TONG, Warwick Bonner; WO2014/27199; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia