Category: 6237-96-3

Temple, Carroll Jr.’s team published research in Journal of Organic Chemistry in 1966 | CAS: 6237-96-3

4,6-Dichloro-2-ethylpyrimidin-5-amine(cas: 6237-96-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Formula: C6H7Cl2N3

In 1966,Journal of Organic Chemistry included an article by Temple, Carroll Jr.; Montgomery, John A.. Formula: C6H7Cl2N3. The article was titled 《Some unusual reactions of 6-chloropurines with thioureas. 6-Alkylthiopurines and 2,2-diamino-2H-thiazolo[3,4,5-gh]purines from 2-(purin-6-yl)-2-thiopseudoureas》. The information in the text is summarized as follows:

Reaction of 6-chloropurine (I) with thiourea gave, in addition to purine-6(1H)-thione (II), 2,2-diamino-2H-thiazolo[3,4,5-gh]purine (III). 1-Ethyl-2-thiourea and I provided the corresponding ethyl derivative of III. From the reaction of 6-chloro-2-ethylpurine and thiourea in PrOH, 2-ethylpurine-6(1 H)-thione, 2,2-diamino-7-ethyl-2H-thiazolo[3,4,5-gh]purine, and 2-ethyl-6-(propylthio)purine (IV) were obtained, the formation of IV resulting from solvent participation. 6-Chloro-2,9-diethylpurine and thiourea in PrOH gave 2,9-diethyl-2-(propylthio)purine as a major component. Treatment of I, 2,6-dichloropurine, and 2-amino-6-chloropurine with 2-imidazolidinethione gave the corresponding 6-(2-imidazolinylthio)purine hydrochlorides (V, VI, and VII), resp. The free base of V and VI but not of VII appeared to form derivatives of III by intramol. addition Basic hydrolysis converted V to II, VI to 2-chlorohypoxanthine, and VII to thioguanine containing a trace of guanine. The results came from multiple reactions, including the reaction of 4,6-Dichloro-2-ethylpyrimidin-5-amine(cas: 6237-96-3Formula: C6H7Cl2N3)

4,6-Dichloro-2-ethylpyrimidin-5-amine(cas: 6237-96-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Formula: C6H7Cl2N3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hymans, William E.’s team published research in Journal of Heterocyclic Chemistry in 1976 | CAS: 6237-96-3

4,6-Dichloro-2-ethylpyrimidin-5-amine(cas: 6237-96-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Related Products of 6237-96-3

《1,2,3-Thiadiazolo[5,4-b]pyrimidin-4(5H)ones》 was published in Journal of Heterocyclic Chemistry in 1976. These research results belong to Hymans, William E.. Related Products of 6237-96-3 The article mentions the following:

Potential herbicides I (R = Et, Pr, CHMe2, Bu, CH2CHMe2, CMe3, CH2CMe3) were prepared in 6 steps from RC(:NH)NH2 and CH2(CO2Et)2. In addition to this study using 4,6-Dichloro-2-ethylpyrimidin-5-amine, there are many other studies that have used 4,6-Dichloro-2-ethylpyrimidin-5-amine(cas: 6237-96-3Related Products of 6237-96-3) was used in this study.

4,6-Dichloro-2-ethylpyrimidin-5-amine(cas: 6237-96-3) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Related Products of 6237-96-3

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

New learning discoveries about 6237-96-3

According to the analysis of related databases, 6237-96-3, the application of this compound in the production field has become more and more popular.

Application of 6237-96-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6237-96-3, name is 4,6-Dichloro-2-ethylpyrimidin-5-amine, molecular formula is C6H7Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 128 6-Chloro-5,6-diamino-2-ethylpyrimidine The material prepared in the foregoing Example 127 (6.19 g, 32 mmol) was dissolved in 2-propanol (75 ml) and 10 ml of anhydrous ammonia was added. This was sealed in a pressure vessel and heated at 110 for 4 hr. The mixture was vented and then evaporated to a solid residue under a stream of nitrogen. This residue was leached with CH2 Cl2 (3*10 ml) and the soluble material (3 g) was shown (tlc, EtOAc:hexanes, 1:1) to be predominantly unreacted starting material, whereas the insoluble material (3.29 g, 19 mmol) was chromatographically pure title compound, suitable for the next reaction (Yield, 60%; quantitative, based on recovered starting material).

According to the analysis of related databases, 6237-96-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Merck & Co., Inc.; US5057517; (1991); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia