Category: 62458-96-2

Adding a certain compound to certain chemical reactions, such as: 62458-96-2, 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C14H15N3O, blongs to pyrimidines compound. Computed Properties of C14H15N3O

A 2-necked 1 liter KBF (round bottom flask) was charged with ethyl l-benzyl-3- oxopiperidine-4-carboxylate (30 g, 101 mmol), formamidine acetic acid salt (10.5 g, 101 mmol) and EtOH (450 mL). The resulting mixture was stirred at 0C and treated with NaOEt (21% in EtOH) (112.6 mL, 299 mmol). The reaction mixture was heated at 60 C overnight and monitored for completion via LCMS and TLC (DCM:MeOH::95:5) (DCM – dichloromethane). Additional starting carboxylate (1 g) was added, followed by another gram of the same after 12 h with continued heating at 60 C. The reaction was complete after 4 h as indicated by LCMS. The cooled reaction was concentrated under vacuum and the residue was treated with cone. HCl (300 mL) and stirred overnight at room temperature. The solvents EPO were removed under vacuum and the resulting solids were treated with EtOH (300 mL), stirred for 15 minutes and then filtered to furnish 44g of crude 7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one as the HCl salt, which was used as such for the next step without further purification.LCMS (0.1% formic acid modifier) calculated. (M+l)+ 242.12, observed 242.3.1H NMR (CD3OD) (free base) delta 7.98 (s, 1 H), 7.35 – 7.32 (m, 5 H), 3.72 (s, 2 H), 3.41 – 3.40 (m, 2H),2.75 (t, J= 5.7 Hz, 2 H), 2.57 (m, 2 H).

The synthetic route of 62458-96-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RENOVIS, INC.; WO2007/28022; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 62458-96-2, name is 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. Safety of 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

31-A. 4-Oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-Patent; NOVARTIS AG; ARTMAN III, Gerald David; ELLIOTT, Jason Matthew; JI, Nan; LIU, Donglei; MA, Fupeng; MAINOLFI, Nello; MEREDITH, Erik; MIRANDA, Karl; POWERS, James J.; RAO, Chang; WO2010/66684; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 62458-96-2, name is 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. name: 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

31-A. 4-Oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-Patent; NOVARTIS AG; ARTMAN III, Gerald David; ELLIOTT, Jason Matthew; JI, Nan; LIU, Donglei; MA, Fupeng; MAINOLFI, Nello; MEREDITH, Erik; MIRANDA, Karl; POWERS, James J.; RAO, Chang; WO2010/66684; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 62458-96-2 , The common heterocyclic compound, 62458-96-2, name is 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one, molecular formula is C14H15N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 1362-[3-(7-Benzyl-4-oxo-5,6,7,8-tetrahydro-4H-pyrido[3,4-d]pyrimidin-3-yl)-phi dimethyl- 1, 2,3 ,4-tetrahydro-quinoline-6-carboxylic acidA mixture of 2-(3-bromo-phenyl)-3,3-dimethyl-l,2,3,4-tetrahydro-quinoline-6-carboxylic acid (360 mg, 1.0 mmol), 7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one (300 mg, 1.3 mmol), copper(I) iodide (80 mg, 0.4 mmol), N, N-dimethylglycine hydrochloride (117 mg, 0.8 mmol) and potassium carbonate (769 mg, 5.6 mmol) in dimethyl sulfoxide (5 mL) was stirred at 120C for 16 h. Then the reaction mixture cooled to room temperature. The reaction mixture was extracted with ethyl acetate (2 x 150 mL), washed with water (2 x 50 mL) and saturated aqueous ammonium chloride solution (2 x 50 mL), dried over anhydrous sodium sulfate and then concentrated in vacuo. Purification by Waters automated flash system (column: Xterra 30 mm x 100 mm, sample manager 2767, pump 2525, detector: ZQ mass and UV 2487, solvent system: acetonitrile and 0.1% ammonium hydroxide in water) afforded 2-[3-(7-benzyl-4-oxo-5,6,7,8-tetrahydro-4H- pyrido[3,4-d]pyrimidin-3-yl)-phenyl]-3,3-dimethyl-l,2,3,4-tetrahydro-quinoline-6- carboxylic acid (320 mg, 61%) as a white solid : LC/MS m/e calcd for C32H32N4O3 (M+H)+: 521.64, observed: 521.2.

The synthetic route of 62458-96-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; FENG, Lichun; HUANG, Mengwei; LIU, Yongfu; WU, Guolong; WU, Jim, Zhen; ZHOU, Mingwei; WO2011/128251; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 62458-96-2, 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C14H15N3O, blongs to pyrimidines compound. Computed Properties of C14H15N3O

B. 7-Benzyl-4-chloro-5, 6,7, 8-tetrahydropyrido [3, 4-d] pyrimidine [00228] 7-Benzyl-5, 6,7, 8-tetrahydro-3H-pyrido [3,4-d] pyrimidin-4-one (9.4g, 39mmol) was dissolved in anhydrous 1,2-dichloroethane and stirred under N2 (g) atmosphere. To the mixture was added POC13 (29mL, 312mmol), followed by N, N-dimethyl aniline (4.75g, 39mmol). The mixture was refluxed for 2 h and the solvents were removed under vacuum to give a red residue. The residue was dissolved in 20 mL of ethyl acetate and 20ml of water was added. The solution was neutralized with ice and solid NaHC03. After neutralization, ethyl acetate was added and the orgarhC layer’was washed with water ana Dnne. ine organic layer was dried over Na2SO4 and the solvents were removed under vacuum. The resulting red residue was purified using a gradient of ethyl acetate: hexane (0-100%) to give the desired compound as yellow crystals (3.8g, 38%).

The synthetic route of 62458-96-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RENOVIS, INC.; WO2005/66171; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 62458-96-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62458-96-2, name is 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one. A new synthetic method of this compound is introduced below.

To 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one (Step A, 1.50 g, 6.22 mmol) in toluene (25 mL) were sequentially added DIPEA (0.87 mL, 5.0 mmol) and POCl3 (0.70 mL, 7.46 mmol). The contents were heated at 105 C. for 2 hour, cooled to rt, diluted with dichloromethane (100 mL) and stirred with cold aq. sat’d NaHCO3 (150 mL) for 1 h. The dichloromethane layer was dried over sodium sulfate and concentrated under reduced pressure to afford the title compound b (1.61 g) as a dark oil. LCMS [M+H]+ 260.08.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62458-96-2, its application will become more common.

Reference:
Patent; Bristol-Myers Squibb Company; US2008/275052; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 62458-96-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62458-96-2, name is 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one, molecular formula is C14H15N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 39 7- (3-Chloropyridin-2-yl)-5, 6,7, 8-tetrahydro-N-phenethylpyrido [3,4-d] pyrimidin-4-amine A. 5,6, 7, 8-Tetrahydropyrido [3,4-d] pyrimidin-4 (3H) -one [00306] 7-Benzyl-5, 6,7, 8-tetrahydropyrido [3,4-d] pyrimidin-4 (3H)-one (1. 5g, 6.2mmol) was dissolved in methanol (25mL) and palladium hydroxide was added (1. 5g, 20% wt). The mixture was shaken on a Parr Shaker under H2 (g) atmosphere (60 PSI) for 3 days. The mixture was filtered through celite and evaporated to give 0.9g of material as a yellow solid (96%), which was used as such for the next step.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 62458-96-2, 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one.

Reference:
Patent; RENOVIS, INC.; WO2005/66171; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia