Category: 626-48-2

Semenov, Vyacheslav E.; Zueva, Irina V.; Mukhamedyarov, Marat A.; Lushchekina, Sofya V.; Petukhova, Elena O.; Gubaidullina, Lilya M.; Krylova, Evgeniya S.; Saifina, Lilya F.; Lenina, Oksana A.; Petrov, Konstantin A. published an article in 2020, the title of the article was Novel acetylcholinesterase inhibitors based on uracil moiety for possible treatment of Alzheimer disease.Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

In this study, novel derivatives based on 6-methyluracil and condensed uracil were synthesized, namely, 2,4-quinazoline-2,4-dione with ω-(ortho-nitrilebenzylethylamino) alkyl chains at the N atoms of the pyrimidine ring. In this series of synthesized compounds, the polymethylene chains were varied from having tetra- to hexamethylene chains, and secondary NH, tertiary ethylamino, and quaternary ammonium groups were introduced into the chains. The mol. modeling of the compounds indicated that they could function as dual binding site acetylcholinesterase inhibitors, binding to both the peripheral anionic site and active site. The data from in vitro experiments show that the most active compounds exhibit affinity toward acetylcholinesterase within a nanomolar range, with selectivity for acetylcholinesterase over butyrylcholinesterase reaching four orders of magnitude. In vivo biol. assays demonstrated the potency of these compounds in the treatment of memory impairment using an animal model of Alzheimer disease. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to methyluracil derivative acetylcholinesterase inhibitor alzheimer, 6-methyluracil, alzheimer disease, acetylcholinesterase, inhibitors, peripheral anionic site, Placeholder for records without volume info and other aspects.Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 31, 2014, Prokofev, Igor I.; Lashkov, Alexander A.; Gabdulkhakov, Azat G.; Dontsova, Mariya V.; Seregina, Tatyana A.; Mironov, Alexander S.; Betzel, Christian; Mikhailov, Al’bert M. published an article.Application of 626-48-2 The title of the article was Crystallization and preliminary X-ray study of Vibrio cholerae uridine phosphorylase in complex with 6-methyluracil. And the article contained the following:

Uridine phosphorylase catalyzes the phosphorolysis of ribonucleosides, with the nitrogenous base and ribose 1-phosphate as products. Addnl., it catalyzes the reverse reaction of the synthesis of ribonucleosides from ribose 1-phosphate and a nitrogenous base. However, the enzyme does not catalyze the synthesis of nucleosides when the substrate is a nitrogenous base substituted at the 6-position, such as 6-methyluracil (6-MU). In order to explain this fact, it is essential to investigate the three-dimensional structure of the complex of 6-MU with uridine phosphorylase. 6-MU is a pharmaceutical agent that improves tissue nutrition and enhances cell regeneration by normalization of nucleotide exchange in humans. 6-MU is used for the treatment of diseases of the gastrointestinal tract, including infectious diseases. Here, procedures to obtain the uridine phosphorylase from the pathogenic bacterium Vibrio cholerae (VchUPh), purification of this enzyme, crystallization of the complex of VchUPh with 6-MU, and X-ray data collection and preliminary X-ray anal. of the VchUPh-6-MU complex at at. resolution are reported. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Application of 626-48-2

The Article related to vibrio uridine phosphorylase methyluracil complex crystal structure, 6-methyluracil, vibrio cholerae, bacterial uridine phosphorylase, Enzymes: Structure-Conformation-Active Site and other aspects.Application of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 31, 2019, Rus, Lucia Maria; Donici, Elena; Valica, Vladimir; Prisacari, Viorel; Tomuta, Ioan; Sepeli, Diana; Heghes, Simona Codruta; Iuga, Cristina Adela; Uncu, Livia published an article.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Development, physical-chemical characterization and in vitro antibacterial activity evaluation of a fixed-dose combination isohydrafural-methyluracil hydrophilic ointment. And the article contained the following:

This research was focused on the pharmaceutical development of a novel, fixed-dose combination isohydrafural-methyluracil ointment on a water soluble base – polyethylene glycol (PEG). Differential scanning calorimetry (DSC) and Fourier transform infra-red spectroscopy (FTIR) were applied in order to determine the compatibility between active pharmaceutical ingredients (APIs) and between APIs – excipients. Nine formulations (F1 – F9) were tested for: phys. appearance and homogeneity, pH, viscosity and osmotic activity. The optimal formulation presented the concentrations of PEG 400 – 76.72%, PEG 1500 – 19.18% and a fixed-dose combination of 0.1% isohydrafural and 4% methyluracil. It showed higher antibacterial properties both to Gram-pos. and Gram-neg. bacteria than nitrofural 2% ointment (Furacilin, Belarus). The long-term stability testing of the optimized formulation of isohydrafural and methyluracil revealed the shelf-life of two years. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to staphylococcus enterococcus escherichia klebsiella pseudomonas proteus isohydrafural methyluracil antibacterial, Placeholder for records without volume info and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 31, 2014, Borodkin, G. I.; Elanov, I. R.; Shubin, V. G. published an article.Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Eco-friendly fluorination of 6-methyl- and 1,3,6-trimethyluracils in water. And the article contained the following:

We examined the reaction of 6-methyl- and 1,3,6-trimethyluracils with F-TEDA-BF4, 4-chloromethyl-1-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), in water. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to fluorination uracil green chem water, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 20, 2017, He, Chun-Yang; Kong, Jingjing; Li, Xuefei; Li, Xiaofei; Yao, Qiuli; Yuan, Fu-Ming published an article.COA of Formula: C5H6N2O2 The title of the article was Visible-Light-Induced Direct Difluoroalkylation of Uracils, Pyridinones, and Coumarins. And the article contained the following:

An efficient and general method for the synthesis of difluoroalkylated uracils, pyridinones, and coumarins through visible-light-induced reaction with com. materials is developed. The strategy proceeds with high efficiency under mild reaction conditions and shows excellent functional group compatibility, even toward bromide and hydroxyl group, thus demonstrates high potent application in a late-stage fluoroalkylation. Moreover, the difluoroalkylated products can be further transformed to a diverse variety of difluoroalkylated heterocycles, including mols. of potential biol. activity. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).COA of Formula: C5H6N2O2

The Article related to photochem fluoroalkylation uracil pyridinone coumarin visible light, General Organic Chemistry: Synthetic Methods and other aspects.COA of Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 6, 2019, Li, Xue-Dong; Gao, Yu-Ting; Sun, Ying-Jie; Jin, Xiao-Yang; Wang, Dong; Liu, Li; Cheng, Liang published an article.Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was A NaI/H2O2-Mediated Sulfenylation and Selenylation of Unprotected Uracil and Its Derivatives. And the article contained the following:

An efficient iodide-catalyzed/hydrogen peroxide mediated sulfenylation and selenylation of unprotected uracil and its derivatives with simple thiols and diselenides was established. This coupling tolerates a broad variety of functional groups to provide diverse 5-sulfur/selenium-substituted uracil derivatives in good to excellent yields (up to 93%). The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to sodium iodide hydrogen peroxide sulfenylation selenylation unprotected uracil derivative, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Qin, Zhen; Liu, Jia; Qiu, Bo; Luo, Hai published an article in 2012, the title of the article was Reactive desorption electrospray ionization mass spectrometry of self-assembled quintets of uracil and its homologues.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

The authors use reactive desorption electrospray ionization (DESI) to investigate the formation of quintets of uracil and homologs (thymine, 6-methyluracil, 5-ethyluracil, 5,6-dimethyluracil) sep. in the spray solvent and on the surface. Exchange reactions for the subunit(s) of the quintet are observed Furthermore, the different signal distributions of the homo-subunit and hetero-subunit quintets formed from any two of the uracil homologs can be compared by using the values of a specially defined molar ration Rm. The results provide a relative stability order for the quintets formed by each of the homologs, which is in agreement with that obtained by DFT calculations The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to reactive desorption electrospray ionization mass spectrometry uracil homolog quintet, Biochemical Methods: Spectral and Related Methods and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 31, 2013, Solomonov, Alexey V.; Rumyantsev, Evgeniy V.; Ivanov, Sergey P.; Kochergin, Boris A.; Antina, Elena V. published an article.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Spectroscopic studies of the supramolecular interactions between uracil and 5-hydroxy-6-methyluracil with bovine serum albumin and its bilirubin complex. And the article contained the following:

Using fluorescence and UV-visible absorption spectroscopy, the interaction of bovine serum albumin (BSA) and its bilirubin complex with uracil and 5-hydroxy-6-methyluracil in phosphate buffer at pH 7.4 was investigated. The parameters of forming intermol. complexes (binding constants, quenching rate constants, the radius of the quenching sphere, etc.) were determined The interaction between BSA and the uracils was carried out by static quenching of protein fluorescence and had predominantly hydrophobic character. Using synchronous fluorescence spectroscopy, the influence of uracil and 5-hydroxy-6-methyluracil on the conformational changes of the protein mol. was studied. The uracils effectively bound to the bilirubin-BSA complex compared to the free protein, which was caused by the interaction with the tetrapyrrolic pigment in the macromol. complex. Mol. docking calculations were also performed. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to serum albumin interaction uracil hydroxymethyluracil spectroscopy protein conformational change, General Biochemistry: Proteins and Their Constituents and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 5, 2018, Kozanecka-Okupnik, Weronika; Jasiewicz, Beata; Pospieszny, Tomasz; Jastrzab, Renata; Skrobanska, Monika; Mrowczynska, Lucyna published an article.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Spectroscopy, molecular modeling and anti-oxidant activity studies on novel conjugates containing indole and uracil moiety. And the article contained the following:

Herein we describe our results on the synthesis and mol. modeling of new conjugates containing indole and uracil moiety. This group of compounds was synthesized by the reaction of indole alkaloid – gramine with appropriate uracil (uracil, 2-thiouracil, 6-methyl-2-thiouracil, thymine, 6-methyluracil and barbituric acid) using DMF as solvent. The structures of all products were confirmed by spectroscopic (1H NMR, 13C NMR, and FT-IR) anal., mass spectrometry (EI) and PM5 semiempirical methods. Moreover the protonation constants for studied compounds were determined The obtained conjugates were screened in vitro for antioxidant and haemolytic activities, and for the protective effects against 2,2′-azobis (2-methylpropionamidine) dihydrochloride (AAPH)-induced oxidative haemolysis of human erythrocytes. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to oxidant conjugate indole alkaloid uracil preparation, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 31, 2017, Akbarzadeh, Marzieh; Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali published an article.HPLC of Formula: 626-48-2 The title of the article was Synthesis of novel derivatives of (benz)imidazo[2,1-b]pyrimido[4,5-d][1,3]thiazine. And the article contained the following:

Several derivatives of the novel heterocyclic systems 2-substituted-imidazo- and benzimidazo-[2,1-b]pyrimido[4,5-d][1,3]thiazine were synthesized through the one-pot cyclocondensation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with imidazolidine-2-thione and 1H-benzimidazole-2(3H)-thione and subsequently substituted by various secondary amines in moderately good yields. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to amino imidazopyrimidothiazine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazines and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia