Category: 626-48-2

Akbarzadeh, Marzieh; Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali; Azizollahi, Hamid; Mague, Joel T. published an article in 2018, the title of the article was Synthesis of 2-substituted-4-methyl-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-b]quinoxaline as a new heterocyclic system.Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

2-Substituted-4-methyl-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-b]quinoxalines, e.g., I, were synthesized through cyclocondensation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with 3-aminoquinoxaline-2-thiol and subsequent substitution by various secondary amines. Regioselective heterocyclization was confirmed by X-ray crystallog. anal. for 4-methyl-2-(pyrrolidin-1-yl)-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-b]quinoxaline (I). The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to chloropyrimidinylmethylthio quinoxalinamine heterocyclization, chloropyrimidothiazepinoquinoxaline preparation secondary amine amination, aminopyrimidothiazepinequinoxaline preparation and other aspects.Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 15, 2012, Matyugina, Elena; Khandazhinskaya, Anastasia; Chernousova, Larisa; Andreevskaya, Sofia; Smirnova, Tatiana; Chizhov, Alexander; Karpenko, Inna; Kochetkov, Sergey; Alexandrova, Ludmila published an article.Product Details of 626-48-2 The title of the article was The synthesis and antituberculosis activity of 5′-nor carbocyclic uracil derivatives. And the article contained the following:

A series of new carbocyclic uracil derivatives, e.g. I, were synthesized and evaluated as potential antituberculosis agents. Racemic hydroxy-cyclopentenyl-5-tetradecynyluracil I completely inhibited the growth of Mycobacterium tuberculosis H37Rv in vitro at a concentration of 10 μg/mL. Individual (+) and (-) isomers of the above uracil derivative were isolated and showed the same level of activity against two strains of Mycobacterium tuberculosis: laboratory sensitive (H37Rv) and drug resistant to five top antituberculosis drugs (MS-115). The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Product Details of 626-48-2

The Article related to drug resistance antituberculosis mycobacterium tuberculosis carbocyclic nucleoside preparation, carbocyclic nucleoside uracil preparation antituberculosis hydroxycyclopentenyltetradecynyluracil mycobacterium tuberculosis antibacterial and other aspects.Product Details of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 30, 2021, Yu. Strobykina, Irina; Voloshina, Alexandra D.; Andreeva, Olga V.; Sapunova, Anastasiia S.; Lyubina, Anna P.; Amerhanova, Syumbelya K.; Belenok, Mayya G.; Saifina, Liliya F.; Semenov, Vyacheslav E.; Kataev, Vladimir E. published an article.Electric Literature of 626-48-2 The title of the article was Synthesis, antimicrobial activity and cytotoxicity of triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogues. And the article contained the following:

Four new triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogs were synthesized by coupling with 8-bromoctyl- or 10- bromdecyltriphenylphosphonium bromide and evaluated for the in vitro antibacterial activity against S. aureus, B. cereus, E. faecalis, two MRSA strains isolated from patients and resistant to fluoroquinolone antibiotic ciprofloxacin and β-lactam antibiotic amoxicillin, E. coli, antifungal activity against T. mentagrophytes C. albicans and cytotoxicity against human cancer cell lines M-HeLa, MCF-7, A549, HuTu-80, PC3, PANC-1 and normal cell line Wi-38. In these compounds a TPP cation was attached via an octyl or a decyl linker to the N 3 atom of the heterocycle moiety (thymine, 6-methyluracil, quinazoline-2,4-dione) which was bonded with 2′,3′,5′-tri- O – acetyl-greek beta-D-ribofuranose residue by the (1,2,3-triazol-4-il)methyl bridge. All synthesized compounds showed high antibacterial activity against S. aureus within the range of MIC values 1.2-4.3 greek muM, and three of them appeared to be bactericidal with respect to tis bacterium at MBC values 4.1-4.3 greek muM. Two lead compounds showed both high antibacterial activity against the MRSA strains resistant to Ciprofloxacin and Amoxicillin within the range of MIC values 1.0-4.3 greek muM and high cytotoxicity against human cancer cell lines HuTu-80 and MCF-7 within the range of IC50 values 6.4-10.2 greek muM. This is one of the few examples when phosphonium salts exhibited both antibacterial activity and cytotoxicity against human cancer cell lines. According to the results obtained the bactericidal effect of the lead compounds, unlike classical surfactants, was not caused by a violation of the integrity of the cytoplasmic membrane of bacteria and their cytotoxic activity is most likely associated both with the induction of apoptosis along the mitochondrial pathway and the arrest of the cell cycle in the G0/G1 phase. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Electric Literature of 626-48-2

The Article related to breast adenocarcinoma triphenylphosphonium fluorouracil doxorubicin cytotoxicity antimicrobial anticancer, antimicrobial activity, click chemistry, cytotoxicity, nucleoside analogues, phosphonium salts, tpp-conjugates and other aspects.Electric Literature of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 1, 2014, Na, Na; Shi, Ruixia; Long, Zi; Lu, Xin; Jiang, Fubin; Ouyang, Jin published an article.Name: 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Real-time analysis of self-assembled nucleobases by Venturi easy ambient sonic-spray ionization mass spectrometry. And the article contained the following:

The real-time anal. of self-assembled nucleobases was employed by Venturi easy ambient sonic-spray ionization mass spectrometry (V-EASI-MS). With the anal. of three nucleobases including 6-methyluracil (6MU), uracil (U) and thymine (T) as examples, different orders of clusters centered with different metal ions were recorded in both pos. and neg. modes. Compared with the results obtained by traditional electrospray ionization mass spectrometry (ESI-MS) under the same condition, more clusters with high orders, such as [6MU7+Na]+, [6MU15+2NH4]2+, [6MU10+Na]+, [T7+Na]+, and [T15+2NH4]2+ were detected by V-EASI-MS, which demonstrated the soft ionization ability of V-EASI for studying the noncovalent interaction in a self-assembly process. Furthermore, with the injection of K+ to the system by a syringe pumping, the real-time monitoring of the formation of nucleobases clusters was achieved by the direct extraction of samples from the system under the Venturi effect. Therefore, the effect of cations on the formation of clusters during self-assembly of nucleobases was demonstrated, which was in accordance with the reports. Free of high voltage, heating or radiation during the ionization, this technique is much softer and suitable for obtaining the real-time information of the self-assembly system, which also makes it quite convenient for extraction samples from the reaction system. This “easy and soft” ionization technique provided a potential pathway for monitoring and controlling the self-assembly processes. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Name: 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to self assembled nucleobase venturi sonic spray ionization mass spectrometry, cations, on-line analysis, real-time monitoring, self-assembled nucleobases, venturi easy ambient sonic-spray ionization mass spectrometry and other aspects.Name: 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 15, 2015, Li, Wei; Liu, Yucan; Duan, Jinming; van Leeuwen, John; Saint, Christopher P. published an article.Computed Properties of 626-48-2 The title of the article was UV and UV/H2O2 treatment of diazinon and its influence on disinfection byproduct formation following chlorination. And the article contained the following:

Incomplete oxidation of organic micro-pollutants may result in diverse, intermittent oxidation byproducts, significantly affecting disinfection byproduct (DBP) formation from the original solutions following chlorination. This work assessed DBP formation from diazinon in solution due to the formation of intermittent oxidation byproducts by UV and UV/H2O2 pre-oxidation Monochloroacetic acid (MCAA), dichloroacetic acid (DCAA), trichloroacetic acid (TCAA), chloroform (TCM), dichloroacetonitrile (DCAN), and 1,1,1-trichloroacetone (1,1,1-TCP) were detected for chlorinated diazinon solutions which were treated by UV and UV/H2O2 oxidation DBP formation significantly increased in diazinon solutions treated by UV irradiation Solution pH and H2O2 dose also had distinct effects on DBP formation, depending on the individual DBP species. Speciation and mol. structures of oxidation byproducts were analyzed by mass spectrometry and tandem mass spectrometry. Four main UV oxidation byproducts (2-isopropyl-6-methyl-4-pyrimidinol [IMP], O-analog diazinon [diazoxon], di-Et thiophosphate [DETP], di-Et phosphate [DEP]) were examined individually to identify their relative contribution to DBP formation. Increased total DBP formation of treated diazinon solutions was mainly attributable to its oxidation product, IMP, and its secondary oxidation products; the other 2 fragments, DETP and DEP, had little effect. Its oxidation fragment, diazoxon, intensified MCAA, DCAA, and TCAA formation under UV/H2O2 pre-oxidation conditions. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Computed Properties of 626-48-2

The Article related to water purification chlorination pre oxidation disinfection, hydrogen peroxide uv irradiation pre oxidation water purification, disinfection byproduct formation diazinon containing water chlorination oxidation disinfection, intermittent oxidation product effect disinfection byproduct formation and other aspects.Computed Properties of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 1, 2020, Semenov, Vyacheslav E.; Zueva, Irina V.; Lushchekina, Sofya V.; Lenina, Oksana A.; Gubaidullina, Lilya M.; Saifina, Lilya F.; Shulaeva, Marina M.; Kayumova, Ramilya M.; Saifina, Alina F.; Gubaidullin, Aidar T.; Kondrashova, Svetlana A.; Latypov, Shamil K.; Masson, Patrick; Petrov, Konstantin A. published an article.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was 6-Methyluracil derivatives as peripheral site ligand-hydroxamic acid conjugates: Reactivation for paraoxon-inhibited acetylcholinesterase. And the article contained the following:

New uncharged conjugates of 6-methyluracil derivatives with imidazole-2-aldoxime I (n = 1, 2, 3, 4) and 1,2,4-triazole-3-hydroxamic acid units II (n = 2, 3, 4) were synthesized and studied as reactivators of organophosphate-inhibited cholinesterase. Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. The reactivating efficacy of one compound II (n = 3) is lower than that of pyridinium-2-aldoxime (2-PAM). Meanwhile, unlike 2-PAM, in vivo study showed that the lead compound II (n = 3) is able: (1) to reactivate POX-inhibited AChE in the brain; (2) to decrease death of neurons and, (3) to prevent memory impairment in rat model of POX-induced neurodegeneration. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to methyluracil imidazole aldoxime triazole hydroxamic acid preparation mol docking, reactivator paraoxon acetylcholinesterase butyrylcholinesterase inhibitor, 3,6-dimethyluracil, acetylcholinesterase, hydroxamic acids, molecular modeling, paraoxon, reactivator and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 26, 2020, Curti, Claudio; Rassu, Gloria; Lombardo, Marco; Zambrano, Vincenzo; Pinna, Luigi; Battistini, Lucia; Sartori, Andrea; Pelosi, Giorgio; Zanardi, Franca published an article.Application of 626-48-2 The title of the article was Unlocking Access to Enantiopure Fused Uracils by Chemodivergent [4+2] Cross-Cycloadditions: DFT-Supported Homo-Synergistic Organocatalytic Approach. And the article contained the following:

The discovery of chem. methods enabling the construction of carbocycle-fused uracils which embody a three-dimensional and functional-group-rich architecture is a useful tool in medicinal chem. oriented synthesis. In this work, an unprecedented amine-catalyzed [4+2] cross-cycloaddition is documented; it involves remotely enolizable 6-methyluracil-5-carbaldehydes and β-aryl enals, and chemoselectively produces two novel bicyclic and tricyclic fused uracil chemotypes in good yields with a maximum level of enantiocontrol. In-depth mechanistic investigations and control experiments support an intriguing homo-synergistic organocatalytic approach, where the same amine organocatalyst concomitantly engages both aldehyde partners in a stepwise eliminative [4+2] cycloaddition, whose vinylogous iminium ion intermediate product may diverge-depending upon conditions-to either bicyclic targets by hydrolysis or tricyclic products by a second homo-synergistic trienamine-mediated stepwise [4+2] cycloaddition The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Application of 626-48-2

The Article related to uracil cinnamaldehyde chemoselective regioselective diastereoselective enantioselective organocatalysis cycloaddition, carbocycle fused uracil stereoselective preparation, asymmetric synthesis, cycloaddition, fused-ring systems, heterocycles, organocatalysis and other aspects.Application of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 30, 2019, Garlito, Borja; Ibanez, Maria; Portoles, Tania; Serrano, Roque; Amlund, Heidi; Lundebye, Anne-Katrine; Sanden, Monica; Berntssen, Marc H. G.; Hernandez, Felix published an article.Formula: C5H6N2O2 The title of the article was LC-MS/MS method for the determination of organophosphorus pesticides and their metabolites in salmon and zebrafish fed with plant-based feed ingredients. And the article contained the following:

The composition of Atlantic salmon feed has changed considerably over the last two decades from being marine-based (fishmeal and fish oil) to mainly containing plant ingredients. Consequently, concern related to traditional persistent contaminants typically associated with fish-based feed has been replaced by other potential contaminants not previously associated with salmon farming. This is the case for many pesticides, which are used worldwide to increase food production, and may be present in plant ingredients. Earlier studies have identified two organophosphorus pesticides, chlorpyrifos-Me and pirimiphos-Me, in plant ingredients used for aquafeed production In the present study, we developed a reliable and sensitive anal. method, based on liquid chromatog. coupled to tandem mass spectrometry, for the determination of these pesticides and their main metabolites in warm water (zebrafish) and cold water (Atlantic salmon) species, where possible differences in metabolites could be expected. The method was tested in whole zebrafish and in different salmon tissues, such as muscle, bile, kidney, fat, and liver. The final objective of this work was to assess kinetics of chlorpyrifos-Me and pirimiphos-Me and their main metabolites in fish tissue, in order to fill the knowledge gaps on these metabolites in fish tissues when fed over prolonged time. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Formula: C5H6N2O2

The Article related to lc ms organophosphorus pesticide bioaccumulation metabolite salmon zebrafish, plant based feed contamination salmo danio chlorpyrifos pirimiphos methyl, atlantic salmon, chlorpyrifos-methyl, lc-ms/ms, metabolites, pirimiphos-methyl, zebrafish and other aspects.Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia