Category: 626-48-2

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H6N2O2. In an article, author is Velihina, Yevheniia,once mentioned of 626-48-2, HPLC of Formula: C5H6N2O2.

Synthesis, in silico and in vitro Evaluation of Novel Oxazolopyrimidines as Promising Anticancer Agents

New potential bioactive oxazolopyrimidines have been synthesized using two main approaches: the pyrimidine ring annulation on a functionalized oxazole and the benzoyl bromide trimerization followed by rearrangement and formation of the oxazolo[5,4-d]pyrimidine scaffold. The docking analyzes have shown that 7-piperazine substituted oxazolo[4,5-d]pyrimidines 8a-8c could be potential VEGFR2 inhibitors with high free energy of ligand-protein complex formation (Delta G: -10.1, -9.6, -9.8 kcal/mol, respectively). In vitro antitumor assays confirmed theoretical predictions that oxazolo[4,5-d]pyrimidines 8a-8c containing positively charged piperazine moiety should demonstrate significantly higher cytotoxic effects. 4-[5-(4-Chlorophenyl)-2-phenyl[1,3]oxazolo[4,5-d]pyrimidin-7-yl]piperazin-1-ium trifluoroacetate (8c) exhibited a slightly higher antiproliferative effect (IC50=0.21 mu m) than doxorubicin (IC50=0.36 mu m) on MDA-MB-231 cell line and has relatively good results on OVCAR-3 (IC50=1.7 mu m) and HCT-116 (IC50=0.24 mu m) cells.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H6N2O2, belongs to pyrimidines compound. In a document, author is Jawad, Mahmood J., introduce the new discover, Category: pyrimidines.

Synthesis of Novel Pyrimidine Derivatives as Bioisosters of Nifedipine and In Vitro Evaluation of their Antihypertensive Activity

3,4-dihydropyrimidin-2(1H) compounds have been attracted researchers to synthesize them via Beginilli reaction and evaluate their antihypertensive activities as bioisosters of nifedipine. The aim was to evaluate the antihypertensive activities of new synthetic pyrimidine compounds compare with nifedipine. The new compounds were prepared from one pot reaction of thiourea (1), ethyl acetoacetate (2) and/or p-nitrobenzaldehyde, p-tolualdehyde (3), respectively, in acid medium (HCl) yielding pyrimidine 4a-c which in turn were hydrolyzed to carboxylic acid derivatives 5a-c which were chlorinated by SOCl2 to give acyl chlorides 6a-c; finally the latter were reacted with some selected aromatic amines namely, aniline, p-anisidine and p-nitroanilin producing amides 7a-c, 8a-c, and 9a-c, respectively. A total of 95 adult rats were divided into 7 groups and given the new compounds and one group received nifedipine. Rats were anaesthetized and the blood pressure was measured though the carotid artery by using of mercury manometer. Results showed that compound 7a has a better antihypertensive activity with insignificant difference compared to nifedipine, while 8a-c and 9a-c have significant difference as compared with nifedipine that indicated when aniline was used as an aromatic amine provides the highest calcium blocking activity. In conclusion, the best antihypertensive active compounds were amides 7a-c, 8a-c and 9a-c. Better results were obtained especially when the benzene ring of amide is unsubstituted.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 626-48-2. Category: pyrimidines.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Chemistry is an experimental science, Formula: C5H6N2O2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H6N2O2, belongs to pyrimidines compound. In a document, author is Dinastiya, Ekaterina M..

Investigation of 4,6-di(hetero)aryl-substituted pyrimidines as emitters for non-doped OLED and laser dyes

Two novel V-shaped push-pull systems based on a pyrimidine acceptor have been designed and investigated. Low-temperature measurements of the fluorescence and delayed luminescence spectra demonstrated that the emission bands of the compounds have a charge-transfer character. Despite the fact that compounds in thermal vacuum deposition films have a low fluorescence quantum yield, OLED devices based on them show high efficiency, which can be associated with the emission mechanism through delayed fluorescence. It is found that photoproducts, obtaining upon exposure to UV-irradiation of fluorophores in chloroform solution, exhibit laser activity in the red region of the spectrum.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 626-48-2, in my other articles. Formula: C5H6N2O2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione. In a document, author is Liu, Wenjing, introducing its new discovery. Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione.

Design, Synthesis and Biological Evaluation of Novel 4-(4-Methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines as Tubulin Polymerization Inhibitors

A novel series of 4-(4-methoxynaphthalen-1-yl)- 5-arylpyrimidin-2-amines were designed, synthesized, and evaluated for their anticancer activities. Most of the synthesized compounds exhibited moderate to high antiproliferative activity in comparison to the standard drug cisplatin. Among them, 5i bearing ethoxy at the 4-position of the phenyl was found to be the most active on MCF-7 and HepG2 cancer cell lines, with IC50 values of 3.77 +/- 0.36 and 3.83 +/- 0.26 mu M, respectively. Further mechanism study shown that 5i potently inhibited tubulin polymerization, induced cell cycle arrest at G2/M phase and cell apoptosis in MCF-7 cell line. Furthermore, molecular modeling study suggested that 5i probably binds to the colchicine site of tubulin.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 626-48-2 help many people in the next few years. Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, HPLC of Formula: C5H6N2O2626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, SMILES is CC1=CC(NC(N1)=O)=O, belongs to pyrimidines compound. In a article, author is Huo, Jin-Ling, introduce new discover of the category.

Discovery of [1,2,4]triazolo[1,5-a]pyrimidines derivatives as potential anticancer agents

In this work, we reported the discovery of compound 6i with potent antiproliferative activity against MGC-803. Among these compounds, the most potent compound 6i could effectively inhibit MGC-803 (IC50 = 0.96 mu M), being around 38-fold selectivity over GES-1. Further underlying mechanism studies indicated that 6i inhibited the colony formation, migration of MGC-803, and exerted anti-proliferative effect by inducing G0/G1 phase arrest in MGC-803 cells. Cell apoptosis was induced by 6i through activating mitochondria-mediated intrinsic pathway and the death receptor-mediated extrinsic pathway. 6i induced cell apoptosis by elevating the level of ROS. Also, 6i up-regulated pro-apoptotic Bax and p53 level, while down-regulating anti-apoptotic Bcl-2 protein expression. Furthermore, acute toxicity experiment indicated 6i exhibited good safety in vivo. Therefore, 6i may be a template for future development of [1,2,4]triazolo [1,5-a]pyrimidine-based anti-cancer agents. (C) 2020 Elsevier Masson SAS. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 626-48-2. HPLC of Formula: C5H6N2O2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Synthetic Route of 626-48-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, SMILES is CC1=CC(NC(N1)=O)=O, belongs to pyrimidines compound. In a article, author is Yagmur, Hatice Karaer, introduce new discover of the category.

Synthesis, characterization, thermal and electrochemical features of poly (phenoxy-imine)s containing pyridine and pyrimidine units

Poly (4-hydroxybenzaldehyde) was prepared by via the oxidative polymerization process in an aqueous alkaline medium by H2O2 as an oxidant. Then, poly(phenoxy-imine)s were synthesized from the condensation reactions of poly(4-hydroxybenzaldehyde) (P-4HBA) with several amines including pyridine and pyrimidine groups. The structures and characterizations of compounds were made by virtue of FT-IR, NMR, UV-Vis spectroscopy, GPC, TG, DSC, CV, SEM and fluorescence (FL) analyses. The conductivities of poly (phenoxy-imine)s were determined with electrometer by four-point probe technique. The conductivity values of poly (phenoxy-imine)s were increased to be connect with doped factor of iodine. Moreover, the electrical conductivity of the poly (phenoxy-imine)s was also measured and defined which they had semi-conductive features. Fluorescence properties of poly (phenoxy-imine)s and P-4HBA were measured out in DMF solutions to define the optimum concentrations in order to acquire the maximal FL intensities. Average molecular weight of the polymers in number (M-n), and in weight (M-w), and polydispersity index (PDI) values of poly (phenoxy-imine)s and P-4HBA were found from GPC analysis. The M-n, M-w and PDI values of P-4HBA were found to be 9900 Da (M-n), 11,300 Da (M-w) and 1.14, respectively. The electrochemical energy gap (E'(g)) and optical band gap (E-g) values of poly (phenoxy-imine)s were determined from cyclic voltammetry (CV) and UV-Vis measurements, respectively.

Synthetic Route of 626-48-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 626-48-2 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H6N2O2. In an article, author is Gonzalez-Ordenes, Felipe,once mentioned of 626-48-2, SDS of cas: 626-48-2.

Crystal structure and molecular dynamics simulations of a promiscuous ancestor reveal residues and an epistatic interaction involved in substrate binding and catalysis in the ATP-dependent vitamin kinase family members

Enzymes with hydroxymethylpyrimidine/phosphomethylpyrimidine kinase activity (HMPPK) are essential in the vitamin B1 (thiamine pyrophosphate) biosynthesis and recycling pathways. In contrast, enzymes with pyridoxal kinase activity (PLK) produce pyridoxal phosphate (vitamin B6), an essential cofactor for various biochemical reactions. In the ATP-dependent vitamin kinases family, the members of PLK/HMPPK-like subfamily have both enzymatic activities. It has been proposed that the promiscuous PLK activity of ancestral HMPPK enzymes could have been the starting point for this activity. In earlier work, we reconstructed the ancestral sequences of this family and characterized the substrate specificity of the common ancestor between PLK/HMPPK-like and HMPPK enzymes (AncC). From these studies, the Gln45Met mutation was proposed as a critical event for the PLK activity emergence. Here, we crystallize and determine the AncC structure by X-ray crystallography and assess the role of the Gln45Met mutation by site-directed mutagenesis. Kinetic characterization of this mutant shows a significant increase in the PL affinity. Through molecular dynamics simulation and MM/PBSA calculations some residues, important for substrate interactions and catalysis, were identified in the wild type and in the mutated ancestor. Interestingly, a strong epistatic interaction responsible for the evolutionary pathway of the PLK activity in PLK/HMPPK-like enzymes was revealed. Also, other putative mutations relevant to PLK activity in modern PLK/HMPPK-like enzymes were identified.

Interested yet? Keep reading other articles of 626-48-2, you can contact me at any time and look forward to more communication. SDS of cas: 626-48-2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Synthetic Route of 626-48-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, SMILES is CC1=CC(NC(N1)=O)=O, belongs to pyrimidines compound. In a article, author is Zhang, Xiaoyan, introduce new discover of the category.

Serum metabolomic profiling reveals important difference between infants with and without subsequent recurrent wheezing in later childhood after RSV bronchiolitis

We aimed to use serum metabolomics to discriminate infants with severe respiratory syncytial virus (RSV) bronchiolitis who later developed subsequent recurrent wheezing from those who did not and to investigate the relationship between serum metabolome and host immune responses with regard to the subsequent development of recurrent wheezing. Fifty-one infants who were hospitalized during an initial episode of severe RSV bronchiolitis at 6 months of age or less were included and followed for up to the age of 3 years. Of them, 24 developed subsequent recurrent wheezing and 27 did not. Untargeted serum metabolomics was performed by ultraperformance liquid chromatography coupled with high-resolution mass spectrometry (UPLC-MS/MS). Cytokines were measured by multiplex immunoassay. Difference in serum metabolomic profiles was observed between infants who developed recurrent wheezing and those who did not. L-lactic acid level was significantly higher in infants with recurrent wheezing than those without. Pyrimidine metabolism, glycerophospholipid metabolism, and arginine biosynthesis were identified as the most significant changed pathways between the two groups. Moreover, L-lactic acid level was positively associated with serum CXCL8 level. This exploratory study showed that differential serum metabolic signatures during severe RSV bronchiolitis in early infancy were associated with the development of subsequent recurrent wheezing in later childhood.

Synthetic Route of 626-48-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 626-48-2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione. In a document, author is Zhou, Qian, introducing its new discovery. Category: pyrimidines.

Detection of 5-Formylpyrimidines in DNA Based on Chemoselective Labeling

In addition to the four canonical nucleobases of A, G, T and C, hundreds of chemical modifications have been identified in genome DNA. Among them, 5-formylpyrimidines, including 5-formylcytosine (5fC) and 5-formyluracil (5fU) , are naturally occurring pyrimidine-covalent-modifications and are widely distributed in mammalian cells. Emerging evidence indicates that 5fC not only serves as a key intermediate in active DNA demethylation but also carry independent epigenetic significance; while 5fU was always considered to be an oxidative DNA lesion with high genotoxicity. In order to further understand their regulatory functions , it is necessary to develop accurate, sensitive and facile methods for qualitative, quantitative, and localized detection of 5-formylpyrimidines in the whole genome. In this review, we summarized the recent progress in detecting 5-formylpyrimidines from the perspective of selective chemical labeling.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 626-48-2 help many people in the next few years. Category: pyrimidines.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reference of 626-48-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, SMILES is CC1=CC(NC(N1)=O)=O, belongs to pyrimidines compound. In a article, author is Selbach, Mariana Terezinha, introduce new discover of the category.

Evaluation of the cytotoxic and genotoxic effects of Sida planicaulis Cav extract using human neuroblastoma cell line SH-SY5Y

Sida planicaulis is a weed thought to have originated in Brazil, where it is present in abundant quantities, but also this plant is also found in south-central Florida, Indian Ocean Islands, and the Pacific Islands. Sida planicaulis produces neurotoxicity that adversely affects livestock breeding with heavy animal losses and consequent negative impact on Brazil’s economy. The aim of this study was to determine the chemical profile, cytotoxic and genotoxic effects of ethanolic extracts of S. planicaulis collected in winter (leaf extract) and summer (leaf extract and leaf + flower extract) using an in vitro model of human neuroblastoma cell line SH-SY5Y. Phytochemical screening demonstrated the presence of alkaloids, flavonoids, and apolar compounds. Rutin, quercetin, and swainsonine were detected by HPLC and GC/MS, respectively. Phosphorus, potassium, iron, and zinc were the inorganic elements found. Extracts produced cytotoxicity at all concentrations tested (7-4,000 mu g/ml) as evidenced by the colorimetric assay [3-(4,5-dimethyl-thiazol-2-yl) -2,5-diphenyl-tetrazolium bromide (MTT)]. Based upon the alkaline comet assay extracts were found to induce genotoxicity at concentrations ranging from 0.437 to 7 mu g/ml. DNA damage produced by extracts was affirmed using a modified comet assay with the enzymes Endo III and FPG in a concentration dependent manner. Further, enzyme-modified comet assay showed both oxidized purines and pyrimidines, and consequently oxidative stress was related to genomic instability and cell death. Data suggest that low concentrations of ethanolic extracts of S. planicaulis (different seasons) induced increased DNA damage related to oxidative stress and chemical composition.

Reference of 626-48-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 626-48-2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia