Category: 626-48-2

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. COA of Formula: C5H6N2O2, 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, SMILES is CC1=CC(NC(N1)=O)=O, in an article , author is Barrows, Robert D., once mentioned of 626-48-2.

Evaluation of 1,1-cyclopropylidene as a thioether isostere in the 4-thio- thienopyrimidine (TTP) series of antimalarials

The 4-(heteroarylthio)thieno[2,3-d]pyrimidine (TTP) series of antimalarials, represented by 1 and 17, potently inhibit proliferation of the 3D7 strain of P. falciparum (EC50 70-100 nM), but suffer from oxidative metabolism. The 1,1-cyclopropylidene isosteres 6 and 16 were designed to obviate this drawback. They were prepared by a short route that features a combined Peterson methylenation / cyclopropanation transformation of, e. g., ketone 7. Isosteres 6 and 16 possess significantly attenuated antimalarial potency relative to parents 1 and 17. This outcome can be rationalized based on the increased out-of-plane steric demands of the latter two. In support of this hypothesis, the relatively flat ketone 7 retains some of the potency of 1, even though it appears to be a comparatively inferior mimic with respect to electronics and bond lengths and angles. We also demonstrate crystallographically and computationally an apparent increase in the strength of the intramolecular sulfur hole interaction of 1 upon protonation.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 626-48-2, you can contact me at any time and look forward to more communication. COA of Formula: C5H6N2O2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, SMILES is CC1=CC(NC(N1)=O)=O, in an article , author is Song Juan, once mentioned of 626-48-2, Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione.

Synthesis, Crystal Structure and Biological Activity of Ethyl 5-(4-Fluorophenyl)-7-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylate

The title compound, C16H11F4N3O2, was synthesized and structurally characterized by elemental analysis, IR, MS, H-1-NMR and single-crystal X-ray diffraction. This compound has a pyrazolo[1,5-a]pyrimidine skeleton, and it crystallizes in monoclinic system, space group P2(1)/c with a = 20.8547(12), b = 20.5558(10), c = 7.1575(4) angstrom, beta = 96.610(5)degrees, V = 3047.9(3) angstrom(3), Z = 4, D-c = 1.540 g.cm(-3), F(000) = 1440, mu(MoK alpha) = 0.14 mm(-1), R = 0.0546 and wR = 0.1276 for 5370 reflections with I > 2 sigma(I). In addition, biological activity determination results indicated that the title compound exhibited poor inhibitory activity on MKN45 and H460 cancer cell lines.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 626-48-2, you can contact me at any time and look forward to more communication. Recommanded Product: 6-Methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Reference of 626-48-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, SMILES is CC1=CC(NC(N1)=O)=O, belongs to pyrimidines compound. In a article, author is Lyapustin, Daniil N., introduce new discover of the category.

6-Nitro-4,7-dihydroazolo [1,5-a]pyrimidines: an alternative mechanism of formation and studies of alkylation

The mechanism of a multicomponent reaction between aminoazoles, 1-morpholino-2-nitroalkenes, and benzaldehyde was studied in acidic medium. Performing the reaction in acetic acid led to the formation of 6-nitro-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]-pyrimidines, which subsequently underwent a rearrangement. Reaction conditions were proposed for a multicomponent synthesis with trioxane, and the alkylation reactions of 4,7-dihydroazolo[1,5-a]pyrimidine nitro derivatives were optimized.

Reference of 626-48-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 626-48-2 is helpful to your research.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Singh, Namrata, once mentioned the application of 626-48-2, Formula: C5H6N2O2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H6N2O2, molecular weight is 126.11, MDL number is MFCD00006028, category is pyrimidines. Now introduce a scientific discovery about this category.

Highly Stable Pyrimidine Based Luminescent Copper Nanoclusters with Superoxide Dismutase Mimetic and Nitric Oxide Releasing Activity

Copper nanoclusters (CuNCs) are emerging as an interesting class of materials for various biomedical applications. In this work, we have designed highly stable nucleobase-capped luminescent CuNCs and studied the effect of substituents on the cluster composition and photophysical properties. The NCs exhibit exceptional stability in ambient atmosphere and show significant variation in the emission properties with a change in position of substituents on the ligand, thiouracil. This study represents the first example of a nanocluster that functionally mimics the activity of a major antioxidant enzyme, superoxide dismutase (SOD). In addition to their enzyme-mimetic activity, the CuNCs evince controlled release of nitric oxide (NO), a key gaseous molecule of endothelial system from S-nitrosothiol, S-nitrosoglutathione (GSNO). Further, to a greater significance, these luminescent CuNCs are readily taken up by the mammalian cells and exhibit low toxicity. The superoxide dismutase and NO releasing activity of the fluorescent, biocompatible copper nanoclusters suggest their potential application in both therapeutics and bioimaging.

If you are interested in 626-48-2, you can contact me at any time and look forward to more communication. Formula: C5H6N2O2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

In an article, author is Kampers, Linde F. C., once mentioned the application of 626-48-2, Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H6N2O2, molecular weight is 126.11, MDL number is MFCD00006028, category is pyrimidines. Now introduce a scientific discovery about this category.

A metabolic and physiological design study of Pseudomonas putida KT2440 capable of anaerobic respiration

Background: Pseudomonas putida KT2440 is a metabolically versatile, HV1-certified, genetically accessible, and thus interesting microbial chassis for biotechnological applications. However, its obligate aerobic nature hampers production of oxygen sensitive products and drives up costs in large scale fermentation. The inability to perform anaerobic fermentation has been attributed to insufficient ATP production and an inability to produce pyrimidines under these conditions. Addressing these bottlenecks enabled growth under micro-oxic conditions but does not lead to growth or survival under anoxic conditions. Results: Here, a data-driven approach was used to develop a rational design for a P. putida KT2440 derivative strain capable of anaerobic respiration. To come to the design, data derived from a genome comparison of 1628 Pseudomonas strains was combined with genome-scale metabolic modelling simulations and a transcriptome dataset of 47 samples representing 14 environmental conditions from the facultative anaerobe Pseudomonas aeruginosa. Conclusions: The results indicate that the implementation of anaerobic respiration in P. putida KT2440 would require at least 49 additional genes of known function, at least 8 genes encoding proteins of unknown function, and 3 externally added vitamins.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Application of 626-48-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, SMILES is CC1=CC(NC(N1)=O)=O, belongs to pyrimidines compound. In a article, author is Park, Tae Hyun, introduce new discover of the category.

Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development

Aberrant tyrosine-protein kinase Mer (MerTK) expression triggers prosurvival signaling and contributes to cell survival, invasive motility, and chemoresistance in many kinds of cancers. In addition, recent reports suggested that MerTK could be a primary target for abnormal platelet aggregation. Consequently, MerTK inhibitors may promote cancer cell death, sensitize cells to chemotherapy, and act as new antiplatelet agents. We screened an inhouse chemical library to discover novel small-molecule MerTK inhibitors, and identified AZD7762, which is known as a checkpoint-kinase (Chk) inhibitor. The inhibition of MerTK by AZD7762 was validated using an in vitro homogeneous time-resolved fluorescence (HTRF) assay and through monitoring the decrease in phosphorylated MerTK in two lung cancer cell lines. We also determined the crystal structure of the MerTK:AZD7762 complex and revealed the binding mode of AZD7762 to MerTK. Structural information from the MerTK:AZD7762 complex and its comparison with other MerTK:inhibitor structures gave us new insights for optimizing the development of inhibitors targeting MerTK.

Application of 626-48-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 626-48-2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H6N2O2. In an article, author is Pullen, Sonja,once mentioned of 626-48-2, Product Details of 626-48-2.

On the Heterogeneous Nature of Cisplatin-1-Methyluracil Complexes: Coexistence of Different Aggregation Modes and Partial Loss of NH3 Ligands as Likely Explanation

The conversion of the 1 : 1-complex of Cisplatin with 1-methyluracil (1MeUH), cis-[Pt(NH3)(2)(1MeU-N3)Cl] (1 a) to the aqua species cis-[Pt(NH3)(2)(1MeU-N3)(OH2)](+) (1 b), achieved by reaction of 1 a with AgNO3 in water, affords a mixture of compounds, the composition of which strongly depends on sample history. The complexity stems from variations in condensation patterns and partial loss of NH3 ligands. In dilute aqueous solution, 1 a, and dinuclear compounds cis-[(NH3)(2)(1MeU-N3)Pt(mu-OH)Pt(1MeU-N3)(NH3)(2)](+)(3) as well as head-tail cis-[Pt-2(NH3)(4)(mu-1MeU-N3,O4)(2)](2+) (4) represent the major components. In addition, there are numerous other species present in minor quantities, which differ in metal nuclearity, stoichiometry, stereoisomerism, and Pt oxidation state, as revealed by a combination of H-1 NMR and ESI-MS spectroscopy. Their composition appears not to be the consequence of a unique and repeating coordination pattern of the 1MeU ligand in oligomers but rather the coexistence of distinctly different condensation patterns, which include mu-OH, mu-1MeU, and mu-NH2 bridging and combinations thereof. Consequently, the products obtained should, in total, be defined as a heterogeneous mixture rather than a mixture of oligomers of different sizes. In addition, a N-2 complex, [Pt(NH3)(1MeU)(N-2)](+) appears to be formed in gas phase during the ESI-MS experiment. In the presence of Na+ ions, multimers n of 1 a with n=2, 3, 4 are formed that represent analogues of non-metalated uracil quartets found in tetrastranded RNA.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Related Products of 626-48-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 626-48-2, Name is 6-Methylpyrimidine-2,4(1H,3H)-dione, SMILES is CC1=CC(NC(N1)=O)=O, belongs to pyrimidines compound. In a article, author is Haffez, Hesham, introduce new discover of the category.

Synthesis, biological evaluation and molecular docking studies of novel thiopyrimidine analogue as apoptotic agent with potential anticancer activity

This study synthesizes novel 6-amino-5-cyano-4-aryl-2-mercapto pyrimidines and condensed pyrimidines analogues in order to investigate their potential activity as anticancer agents. The compounds were synthesized via one-pot condensation of p-nitrobenzaldehyde or p-anisaldehyde with malononitrile and thiourea to prepare 6amino-5-cyano-4-aryl-2-mercaptopyrimidines series (1-9a,b). The pyrimidine analogues were biologically screened In-vitro in HepG2 and MCF-7 compared to normal WI-38. Compound 8a showed higher anti proliferative activity to MCF-7 cells with sensitivity and minimal cytotoxic effect (IC50 53.3 mu MHepG2, 12.9 mu MMCF-7 and > 100 mu MWI-38). Compound 8a was able to induce 40% of total antioxidants and 60% following treatment with 50 mu M of H2O2 for 3hrs as external source of oxidative stress in MCF-7. 8a was able to significantly induce early stage apoptosis of 74.37% MCF-7 and cell cycle arrest with cells accumulation in subG0-G1 phase to 69.42% and reduction of cells in G2M phase to 3.6% and high apoptotic index. Compound 8a induced over-expression of Fas receptor and Cyto C genes. Molecular docking studies suggested that 8a can bind to both phosphodiesterase 4B and 4D binding pockets and inhibit their action through network of hydrophobic interactions in Q-P pockets with preferential selectivity to PDE4B through invariant Glu443. The chemical profile and the biological results suggest that 8a can be a promising anticancer agent.

Related Products of 626-48-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 626-48-2.

Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia

Synthetic Route of 626-48-2, Adding some certain compound to certain chemical reactions, such as: 626-48-2, name is 6-Methylpyrimidine-2,4(1H,3H)-dione,molecular formula is C5H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 626-48-2.

To a stirred mixture of 96% H2S04(15 mL) and of 70% HN03(15 mL) was added 6- methyl pyrimidine-2,4-(lH,3H)-dione (2.5 g,19.8 mmol). The solution was kept at 50 C for lOh. The mixture was cooled to room temperature and poured into a large volume of ice water. The solid was collected and dried in vacuo. Recrystallization with MeOH gave the final compound (2.7g,16.2 mmol) as yellows solid.1H NMR (200 MHz,DMSO) delta 2.31 (s,3H), 11.82 (s,1H), 11.85 (s,1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 626-48-2, 6-Methylpyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TES PHARMA S.R.L.; PELLICCIARI, Roberto; (253 pag.)WO2018/69532; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia