Category: 626-48-2

On May 31, 2015, Dubovitskii, S. N.; Komissarova, N. G.; Shitikova, O. V.; Spirikhin, L. V.; Abdullin, M. F.; Yunusov, M. S. published an article.Computed Properties of 626-48-2 The title of the article was Synthesis of Betulin 28-(2-Bromoacetate) Conjugates with Uracil and its Methyl-Substituted Homologs. And the article contained the following:

A series of potentially biol. active betulin derivatives containing various C-28 2-uracilacetoxy substituents were synthesized [e.g., betulin bromoester I + uracil → II (88%)]. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Computed Properties of 626-48-2

The Article related to betulin uracil conjugate methyl homolog preparation, Terpenes and Terpenoids: Triterpenes (C30), Including Limonoids and other aspects.Computed Properties of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Fitriana, Adita Silvia; Royani, Sri published an article in 2022, the title of the article was Molecular docking study of chalcone derivatives as potential inhibitors of sars-cov-2 main protease.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

SARS-CoV-2 main protease is a potential target for the development of AntiCOVID-19. Several chalcones have inhibitory activity against 3CLpro SARSCoV and 3CLpro MERS-CoV. This study aims to predict the potential of chalcones in inhibiting 3CLproSARS-CoV-2, which plays a role in the viral replication process. In silico research carried the prediction through mol. docking toward proteins with PDB ID 6LU7 and 6Y2F. Compound K27 has a docking score more neg. than lopinavir. This result indicates that compound K27 is predicted to inhibit the SARS-CoV-2 replication. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to chalcone inhibitor protease mol docking sars cov2, Pharmacology: Effects Of Gastrointestinal and Respiratory Drugs and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 31, 2017, Kabal’nova, Natalia N.; Grabovskiy, Stanislav A.; Andriayshina, Nadezhda M.; Egorov, Vladislav I.; Valiullin, Lenar R.; Nabatov, Alexey A.; Raginov, Ivan S.; Murinov, Yurii I. published an article.Related Products of 626-48-2 The title of the article was The Impact of 5-Substituted Uracil Derivatives on Immortalized Embryo Lung Cells. And the article contained the following:

Background: Pyrimidine-based drugs stimulate tissue regeneration and immunity, two components that need to be improved in a number of respiratory diseases of different etiol. (e.g. influenza and asthma). In the present study we investigated relationships between the character of substitutions in the uracil structure and the impact of the resp. uracil derivatives on the immortalized lung cells. Methods: The level of cell proliferation, maximum tolerated dose and toxic effect of 5-substituted uracil derivatives (12 compounds) were studied on the immortalized lung epithelial cells and compared with the ones of 6-methyluracil. Results: 5-Carboxyuracil and 1,3-dimethyl-5-carboxyuracil had the lowest cytotoxicity among the studied compounds Their maximal tolerated dosage values were 5 times higher whereas the proliferation index was increased by 25% and 75%, resp., compared to 6-methyluracil, known for its pos. effects on cell regeneration. Conclusion: 5-Carboxyuracil and 1,3-dimethyl-5-carboxyuracil have the best perspectives for further studies on their biol. effects. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Related Products of 626-48-2

The Article related to uracil derivative immortalize embryo lung cell, Pharmacology: Effects Of Gastrointestinal and Respiratory Drugs and other aspects.Related Products of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 15, 2016, Hu, Yanjing; Hu, Hanbin; Li, Yingying; Chen, Ruixin; Yang, Yu; Wang, Lei published an article.HPLC of Formula: 626-48-2 The title of the article was Supramolecular assemblies of tetrafluoroterephthalic acid and N-heterocycles via various strong hydrogen bonds and weak C-H···F interactions: Synthons cooperation, robust motifs and structural diversity. And the article contained the following:

A series of organic solid states including three salts, two co-crystals, and three hydrates based on tetrafluoroterephthalic acid (H2tfBDC) and N-bearing ligands (2,4-(1H,3H)-pyrimidine dione (PID), 2,4-dihydroxy-6-Me pyrimidine (DHMPI), 2-amino-4,6-dimethyl pyrimidine (ADMPI), 2-amino-4,6-dimenthoxy pyrimidine (ADMOPI), 5,6-dimenthyl benzimidazole (DMBI), 2-aminobenzimidazole (ABI), 3,5-di-Me pyrazole (DMP), and 3-cyanopyridine (3-CNpy)), namely, [(PID)2·(H2tfBDC)] (1), [(DHMPI)2·(H2tfBDC)] (2), [(H-ADMPI+)2·(tfBDC2-)·2(H2O)] (3), [(H-ADMOPI+)2·(tfBDC2-)·(H2O)] (4), [(H-DMBI+)2·(tfBDC2-)·2(H2O)] (5), [(H-ABI+)2·(tfBDC2-)] (6), [(H-DMP+)·(HtfBDC-)] (7), and [(H-3-CNpy+)·(HtfBDC-)] (8), were synthesized by solvent evaporation method. Crystal structures analyses show that the F atom of the H2tfBDC participates in multiple C-H···F hydrogen bond formations, producing different supramol. synthons. The weak hydrogen bonding C-H···F and N-H···F play an important part in constructing the diversity structures 2-8, except in crystal 1. In complexes 1-3, they present the same synthon R22(8) with different N-heterocyclic compounds, which may show the strategy in constructing the supramol. Meanwhile, the complex 3 exhibits a 2D layer, and the independent mols. of water exist in the adjacent layers. In complexes 4 and 5, the water mols. connect the neighboring layers to form 3D network by strong O-H···O hydrogen bonding. These crystals 1-8 were fully characterized by single-crystal X-ray crystallog., elemental anal., IR spectroscopy (IR), and thermogravimetric anal. (TGA). The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to supramol assemble tetrafluoroterephthalic acid nitrogen heterocycle hydrogen bond tga, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 26, 2014, Teimoory, Faranak; Loppnow, Glen R. published an article.Category: pyrimidines The title of the article was Initial Excited-State Structural Dynamics of 6-Substituted Uracil Derivatives: Femtosecond Angle and Bond Lengthening Dynamics in Pyrimidine Nucleobase Photochemistry. And the article contained the following:

Substituents on the pyrimidine ring of nucleobases appear to play a major role in determining their initial excited-state structural dynamics and resulting photochem. To better understand the determinants of nucleobase initial excited-state structural dynamics, we have measured the absorption and resonance Raman excitation profiles of 6-deuterouracil (6-d-U) and 6-methyluracil (6-MeU). Simulation of the resonance Raman excitation profiles and absorption spectrum with a self-consistent, time-dependent formalism shows the effect of the deuterium and Me group on the photochem. active internal coordinates, i.e. C5C6 stretch and C5X and C6X bends. The Me group on either the C5 or C6 position of uracil equally increases the excited-state reorganization energies along the C5C6 stretch. However, a lower reorganization energy of the C5X + C6X bends in 6-MeU than uracil and 5-MeU shows that C6 Me substituents reduce the bending reorganization energy. In addition, deuterium substitution at either C5 or C6 has a much smaller effect on the initial excited-state structural dynamics than Me substitution, consistent with a mass effect. These results will be discussed in light of the resulting photochem. of pyrimidine nucleobases. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Category: pyrimidines

The Article related to excited state structure dynamic uracil angle bond dft b3lyp, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 21, 2019, Andreeva, Olga V.; Belenok, Maya G.; Saifina, Liliya F.; Shulaeva, Marina M.; Dobrynin, Alexey B.; Sharipova, Radmila R.; Voloshina, Alexandra D.; Saifina, Alina F.; Gubaidullin, Aidar T.; Khairutdinov, Bulat I.; Zuev, Yuriy F.; Semenov, Vyacheslav E.; Kataev, Vladimir E. published an article.HPLC of Formula: 626-48-2 The title of the article was Synthesis of novel 1,2,3-triazolyl nucleoside analogs bearing uracil, 6-methyluracil, 3,6-dimethyluracil, thymine, and quinazoline-2,4-dione moieties. And the article contained the following:

A series of novel 1,2,3-triazolyl nucleoside analogs was synthesized via the CuAAC reaction of N1-alkynyl uracil, 6-methyluracil, 3,6-di-Me uracil, thymine and quinazolin-2,4-dione with protected azido β-D-ribofuranose. The obtained compounds differ in both the nature of the pyrimidine-2,4-dione fragment and the length of the polymethylene linker connecting it with the β-D-ribofuranosyl-1,2,3-triazol-4-yl moiety. The 1,2,3-triazolyl nucleoside analogs were evaluated for their cytotoxicity in vitro. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to quinazolinedione nucleoside analog preparation human angiogenic crystal structure, click alkyne azide triazole cycloaddition catalyst preparation nucleoside analog, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 31, 2020, Sharipova, R. R.; Saifina, L. F.; Belenok, M. G.; Semenov, V. E.; Kataev, V. E. published an article.HPLC of Formula: 626-48-2 The title of the article was First Analog of Pyrimidine Nucleosides with Two D-Ribofuranose Residues. And the article contained the following:

The reaction of 1,3-bis(pent-4-yn-1-yl)-6-methyluracil with 2,3,5-tri-O-acetyl-β-D-ribofuranosyl azide gave 1,3-bis{3-[1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-1,2,3-triazol-4-yl]propyl}-6-methyluracil which was deprotected by treatment with a solution of sodium methoxide in methanol to obtain 1,3-bis{3-[1-(β-D-ribofuranosyl)-1H-1,2,3-triazol-4-yl]propyl}-6-methyluracil as a first analog of pyrimidine nucleosides containing two D-ribofuranose fragments. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to click alkyne azide triazole cycloaddition catalyst preparation, pyrimidine nucleoside preparation ribofuranose pentynylmethyluracil ribofuranosyl azide, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On August 31, 2017, Zhang, Ben-Hou; Kong, Jing-Jing; Huang, Yang; Lou, Yue-Guang; Li, Xiao-Fei; He, Chun-Yang published an article.HPLC of Formula: 626-48-2 The title of the article was Benign perfluoroalkylation of uracils and uracil nucleosides via visible light-induced photoredox catalysis. And the article contained the following:

In this work, an efficient and facile method for the preparation of 5-perfluoroalkylation uracils and uracil nucleosides through visible-light-mediated reaction has been developed. The reaction processes in high efficiency under mild reaction conditions and show broad substrate scope by employing com. available perfluoroalkyl sources, thus demonstrates high potent application in life and medicinal science. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to perfluoroalkyled uracil nucleoside visible light photoredox synthesis, perfluoroalkylation uracil nucleoside visible light photoredox, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Qiu, Yan; Zhang, Yang; Li, Yuhang; Ren, Jie published an article in 2016, the title of the article was Discovery of uracil derivatives as potent inhibitors of fatty acid amide hydrolase.Application In Synthesis of 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biol. degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties. In the present study, a conjugated 2,4-dioxo-pyrimidine-1-carboxamide scaffold was confirmed as a novel template for FAAH inhibitors, based on which, a series of analogs had been prepared for an initial structure-activity relationship (SAR) study. Most of the synthesized compounds displayed moderate to significant FAAH inhibitory potency. Among them, compounds 11 and 14 showed better activity than others, with IC50 values of 21 and 53 nM. SAR anal. indicated that 2,4-dioxopyrimidine-1-carboxamides represented a novel class of potent inhibitors of FAAH, and substitution at the uracil ring or replacement of the N-terminal group might favor the inhibitory potency. Selected compounds of this class may be used as useful parent mols. for further investigation. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Application In Synthesis of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to fatty acid amide hydrolase uracil ethanolamide, faah inhibitor, amidation, fatty acid amide hydrolase (faah), uracil derivatives, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Application In Synthesis of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 31, 2017, Zimin, Yu. S.; Borisova, N. S.; Timerbaeva, G. R.; Gimadieva, A. R.; Mustafin, A. G. published an article.Synthetic Route of 626-48-2 The title of the article was Preparation, Toxicity, and Anti-Inflammatory Activity of Complexes of Uracil Derivatives with Polyfunctional Acids. And the article contained the following:

Uracil derivatives (6-methyluracil, 5-hydroxy-6-methyluracil) and polyfunctional acids (citrus pectin, oxidized fraction of citrus pectin, and 5-aminosalicylic acid) were shown to form rather stable 1:1 complexes, i.e., one uracil mol. for each carboxylic acid of the polyfunctional acid. Synthetic methods for these complexes were developed based on the results. Their toxicity and anti-inflammatory activity were studied. It was established that complexes of 6-methyluracil with the oxidized fraction of citrus pectin and of 5-hydroxy-6-methyluracil with 5-aminosalicylic acid possessed low toxicity and high anti-inflammatory activity. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Synthetic Route of 626-48-2

The Article related to uracil derivative complexation toxicity antiinflammatory, Pharmacology: Effects Of Inflammation Inhibitors and Immune Agents and other aspects.Synthetic Route of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia