Category: 626-48-2

On December 31, 2019, Gainullina, Yu. Yu.; Gus’kov, V. Yu.; Timofeeva, D. V. published an article.Synthetic Route of 626-48-2 The title of the article was Polarity of Thymine and 6-Methyluracil-Modified Porous Polymers, According to Data from Inverse Gas Chromatography. And the article contained the following:

Abstract: The affinity of surfaces of porous polymer Polysorb-1 samples modified with thymine (5-methyluracil) and 6-methyluracil toward sorbates capable of various intermol. interactions is studied via inverse gas chromatog. in the infinite dilution mode. It is found that the first modifier yields one-dimensional tape supramol. structures as a result of self-assembling, while the second produces two-dimensional network structures. The contributions from intermol. interactions to the Helmholtz energy of adsorption are calculated via the linear decomposition of retention parameters. The dispersion and specific components of the energy of adsorption are determined according to Dong. It is shown that modifying the surface of a porous polymer with thymine increases both specific and dispersive components of the energy of adsorption, while the contributions from different intermol. interactions and the polarity of the surface as a result of modifying with thymine change slightly. Modifying a porous polymer with the same amount of 6-methyluracil results in a notable rise in polarity, due to an increase in the contributions from interactions of induction and orientation. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Synthetic Route of 626-48-2

The Article related to thymine methyluracil divinylbenzene styrene copolymer surface polarity, Plastics Manufacture and Processing: Physical Properties and Testing Methods and other aspects.Synthetic Route of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On September 30, 2015, Akbarzadeh, Marzieh; Bakavoli, Mehdi; Eshghi, Hossein; Shiri, Ali; Tajabadi, Javad published an article.Category: pyrimidines The title of the article was Synthesis of dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepines; derivatives of a novel ring system. And the article contained the following:

Several derivatives of the novel dihydrobenzo[b]pyrimido[4,5-e][1,4]thiazepine ring system I (NR1 = piperidinyl, morpholinyl, pyrrolidino, etc.) have been synthesized through the initial heterocyclization of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine with o-aminothiophenol followed by treatment with various secondary amines in boiling ethanol. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Category: pyrimidines

The Article related to dihydrobenzopyrimidothiazepine preparation, chloromethylmethylpyrimidine aminothiophenol heterocyclization, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 31, 2018, Chestnova, T. V.; Zilov, V. G.; Gladkikh, P. G.; Khadartsev, A. A.; Korotkova, A. S.; Buzulukov, Yu. P. published an article.SDS of cas: 626-48-2 The title of the article was Combined Effect of Silver Nanoparticles, Ceftriaxone, and Methyluracil during Experimental Purulent Peritonitis. And the article contained the following:

Bacterial biofilms provoke and/or promote the most chronic and recurrent infectious diseases. Previously, exptl. models of purulent peritonitis and meningoencephalitis revealed pos. antibiofilm effect of metallic nanoparticles and the absence of resistance against such nanoparticles in microorganisms. This study examines the combined effect of silver nanoparticles with ceftriaxone and methyluracil on recovery mechanisms during inflammatory diseases exemplified by purulent peritonitis in exptl. animals. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).SDS of cas: 626-48-2

The Article related to purulent peritonitis silver nanoparticle ceftriaxone methyluracil, bacterial biofilms, ceftriaxone, methyluracil, nanoparticles, peritonitis, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.SDS of cas: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 31, 2022, Oba, Yasuhiro; Takano, Yoshinori; Furukawa, Yoshihiro; Koga, Toshiki; Glavin, Daniel P.; Dworkin, Jason P.; Naraoka, Hiroshi published an article.Product Details of 626-48-2 The title of the article was Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites. And the article contained the following:

The lack of pyrimidine diversity in meteorites remains a mystery since prebiotic chem. models and laboratory experiments have predicted that these compounds can also be produced from chem. precursors found in meteorites. Here we report the detection of nucleobases in three carbonaceous meteorites using state-of-the-art anal. techniques optimized for small-scale quantification of nucleobases down to the range of parts per trillion (ppt). In addition to previously detected purine nucleobases in meteorites such as guanine and adenine, we identify various pyrimidine nucleobases such as cytosine, uracil, and thymine, and their structural isomers such as isocytosine, imidazole-4-carboxylic acid, and 6-methyluracil, resp. Given the similarity in the mol. distribution of pyrimidines in meteorites and those in photon-processed interstellar ice analogs, some of these derivatives could have been generated by photochem. reactions prevailing in the interstellar medium and later incorporated into asteroids during solar system formation. This study demonstrates that a diversity of meteoritic nucleobases could serve as building blocks of DNA and RNA on the early Earth. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Product Details of 626-48-2

The Article related to carbonaceous meteorite extraterrestrial purine pyrimidine nucleobase identifying wide diversity, Mineralogical and Geological Chemistry: Cosmochemistry and Meteorites and other aspects.Product Details of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Semenov, Vyacheslav E.; Giniyatullin, Rashit Kh.; Lushchekina, Sofya V.; Kots, Ekaterina D.; Petrov, Konstantin A.; Nikitashina, Alexandra D.; Minnekhanova, Oksana A.; Zobov, Vladimir V.; Nikolsky, Evgeny E.; Masson, Patrick; Reznik, Vladimir S. published an article in 2014, the title of the article was Macrocyclic derivatives of 6-methyluracil as ligands of the peripheral anionic site of acetylcholinesterase.Name: 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

Novel pyrimidinophanes possessing two o-nitrobenzylethyldialkylammonium heads bridging with different spacers were prepared Pyrimidinophanes 2a, 2b and 3 are reversible inhibitors of cholinesterases. They show a very good selectivity for human acetylcholinesterase (AChE), with an inhibitory power 100-200 times higher than for human butyrylcholinesterase (BChE). Docking simulations indicate specific binding of pyrimidinophanes 2a and 4 onto the peripheral anionic site of AChE. Other compounds bind to the active center of AChE as well as to the peripheral anionic site. These compounds are dual binding site inhibitors. Pyrimidinophane 2b and its acyclic counterpart 1 were tested in the animal model of myasthenia gravis and may be considered as valuable candidates for the treatment of pathol. muscle weakness syndromes. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Name: 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to macrocyclic derivative methyluracil ligand peripheral anionic site acetylcholinesterase, Pharmacology: Other (All Agents and Effects Not Otherwise Assignable) and other aspects.Name: 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On January 25, 2012, Liu, Wei-dong; Deng, Xi-ling; Zhang, Zhi-li; Wang, Xiao-wei; Liu, Jun-yi published an article.Electric Literature of 626-48-2 The title of the article was Synthesis of 6-(bromomethyl)-4-methoxy-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-2-ol from 6-methylpyrimidine-2,4-diol. And the article contained the following:

6-(Bromomethyl)-4-methoxy-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-2-ol was synthesized starting from 6-methylpyrimidine-2,4-diol through 6-Me alkylation and intramol. reductive cyclization as key steps. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Electric Literature of 626-48-2

The Article related to hydropyridopyrimidinol preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

del Arco, Jon; Acosta, Javier; Pereira, Humberto M.; Perona, Almudena; Lokanath, Neratur K.; Kunishima, Naoki; Fernandez-Lucas, Jesus published an article in 2018, the title of the article was Enzymatic Production of Non-Natural Nucleoside-5′-Monophosphates by a Thermostable Uracil Phosphoribosyltransferase.Formula: C5H6N2O2 And the article contains the following content:

The use of enzymes as biocatalysts applied to synthesis of modified nucleoside-5′-monophosphates (NMPs) is an interesting alternative to traditional multistep chem. methods which offers several advantages, such as stereo-, regio-, and enantioselectivity, simple downstream processing, and mild reaction conditions. Herein we report the recombinant expression, production, and purification of uracil phosphoribosyltransferase from Thermus themophilus HB8 (TtUPRT). The structure of TtUPRT has been determined by protein crystallog., and its substrate specificity and biochem. characteristics have been analyzed, providing new structural insights into the substrate-binding mode. Biochem. characterization of the recombinant protein indicates that the enzyme is a homotetramer, with activity and stability across a broad range of temperatures (50-80 °C), pH (5.5-9) and ionic strength (0-500 mM NaCl). Surprisingly, TtUPRT is able to recognize several 5 and 6-substituted pyrimidines as substrates. These exptl. results suggest TtUPRT could be a valuable biocatalyst for the synthesis of modified NMPs. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Formula: C5H6N2O2

The Article related to uracil phosphoribosyltransferase nucleoside monophosphate, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 31, 2015, Borodkin, G. I.; Elanov, I. R.; Shubin, V. G. published an article.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Electrophilic fluorination of 6-methyl- and 1,3,6-trimethyluracils in water. And the article contained the following:

The reaction of 4-chloromethyl-1-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) with 6-methyl- and 1,3,6-trimethyluracil in water was studied. According to the kinetic data, the fluorination follows a bimol. mechanism with intermediate formation of cationic σ-complexes. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to electrophilic fluorination methyluracil trimethyluracil water, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 30, 2013, Chernikova, I. B.; Khursan, S. L.; Spirikhin, L. V.; Yunusov, M. S. published an article.Computed Properties of 626-48-2 The title of the article was Electrophilic ipso-substitution in uracil derivatives. And the article contained the following:

Treatment of 5-iodo-1,3,6-trimethyluracil with 50% H2SO4 gives 1,3,6-trimethyluracil; with 5-bromo-1,3,6-trimethyluracil, a mixture of 1,3,6-trimethyluracil and 6-bromomethyl-1,3-dimethyluracil is obtained. 5-Chloro-1,3,6-trimethyluracil remains inert under these conditions. According to the DFT modeling of the reactions of 5-halo-1,3,6-trimethyluracils, a nucleophilic agent can abstract either Hal+ or the Me proton from the carbocation formed by protonation of the starting halouracil at position 5, which accounts for the formation of two products from the 5-bromo derivative Under similar conditions, 6-methyluracil dibromohydrin yields N-bromo-5-bromo-6-hydroxymethyluracil. Bromination or chlorination of 5-hydroxymethyl- or 5-formyl-6-methyluracils follows the ipso-substitution scheme leading to 6-methyluracil 5-halo- and 5,5-dihalohydrins. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Computed Properties of 626-48-2

The Article related to electrophilic ipso substitution uracil derivative, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Computed Properties of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 31, 2022, Chernikova, I. B.; Yunusov, M. S. published an article.Application In Synthesis of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was On the mechanism of deiodination of 5-iodo-1,3,6-trimethyluracil. And the article contained the following:

Dehalogenation of 5-iodo-1,3,6-trimethyluracil in acidic medium in the presence of either KCl or KBr as the nucleophile sources proceeded as the halophilic reaction to give 1,3,6-trimethyluracil. This compound can be iodinated with ICl or IBr generated in the course of the reaction to recover the starting 5-iodo-1,3,6-trimethyluracil. This reverse process can be suppressed by addition of 6-methyluracil. The plausible reaction mechanism is discussed. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Application In Synthesis of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to iodo trimethyluracil dehalogenation mechanism, Physical Organic Chemistry: Addition, Elimination, and Substitution Reactions and other aspects.Application In Synthesis of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia