Category: 626-48-2

On September 30, 2019, Maksyutova, A. A.; Zimin, Yu. S.; Gimadieva, A. R.; Mustafin, A. G. published an article.Computed Properties of 626-48-2 The title of the article was Kinetics of the Oxidation of Uracil and Six of Its Derivatives by Ozone in Aqueous Solutions. And the article contained the following:

The kinetics of the oxidation of uracil and six of its derivatives (thymine, 6-methyluracil, 5-bromo-6-methyluracil, 5-nitro-6-methyluracil, 1,3-dimethylthymine, and 5-hydroxy-1,3,6-trimethyluracil) by ozone in aqueous solutions is studied via spectrophotometry. It is shown that the reactions proceed according to a second-order kinetic law. The temperature dependence of the second-order rate constants is investigated, and the activation parameters of the reaction are determined in the range of 285-309 K. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Computed Properties of 626-48-2

The Article related to uracil ozone oxidation kinetics activation energy molar absorptivity, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Computed Properties of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 31, 2012, Akhatova, G. R.; Safarova, I. V.; Gerchikov, A. Ya.; Enikeev, A. A. published an article.Name: 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Kinetics and mechanism of the reactions of uracil with hydrogen peroxide in aqueous solutions. And the article contained the following:

The kinetics of the reactions of 5-hydroxy-6-methyluracil and 6-methyluracil with hydrogen peroxide in aqueous solutions has been investigated. The reactions proceed via two competitive mechanisms, namely, free-radical and nonradical ones. The iron ions present in water as impurities make possible the free-radical mechanism. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Name: 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to uracil hydrogen peroxide reaction kinetics mechanism iron, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Name: 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 31, 2015, Zimin, Yu. S.; Khairullina, L. R.; Kutlugil’dina, G. G.; Mustafin, A. G. published an article.COA of Formula: C5H6N2O2 The title of the article was Chemiluminescence in the reaction of ozone with 6-methyluracil in aqueous solutions. And the article contained the following:

Chemiluminescence in the visible part of the spectrum during the oxidation of 6-methyluracil with ozone in aqueous solutions was found. The kinetics of variation of the luminescence intensity was studied in the temperature range 287-333 K, and the activation parameters of the process were determined The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).COA of Formula: C5H6N2O2

The Article related to methyluracil ozone chemiluminescence oxidation kinetics, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.COA of Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kasradze, V. G.; Ignatyeva, I. B.; Khusnutdinov, R. A.; Suponitskii, K. Yu.; Antipin, M. Yu.; Yunusov, M. S. published an article in 2012, the title of the article was Oxidative halogenation of 6-methyluracil.Formula: C5H6N2O2 And the article contains the following content:

An efficient method has been developed for the preparation of halo derivatives of 6-methyluracil by employing oxidative halogenation. Elemental halogens and potassium halides were used as the halogenating agents, while NaNO3 and H2O2 were used as the oxidizing agents. Iodination of 6-methyluracil leads to 5-iodo-6-methyluracil as the single reaction product, while bromination or chlorination lead to 5-halo-6-methyluracil, 5,5-dihalo-6-hydroxy-6-methyl-5,6-dihydrouracil, or their mixture depending on the acidity of the medium and the ratio of the substrate and reagents. Bromination of 5-chloro-6-methyluracil leads to 5-bromo-5-chloro-6-hydroxy-6-methyl-5,6-dihydrouracil, while chlorination of 6-methyl-, 5-bromo-6-methyl-, and 5-chloro-6-methyluracils using gaseous chlorine yields 5,5-dichloro-6-hydroxy-6-methyl-5,6-dihydrouracil. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Formula: C5H6N2O2

The Article related to oxidative halogenation methyluracil crystallog, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Firoozi, Neda; Bakavoli, Mehdi; Eshghi, Hossein; Ramezanian, Navid published an article in 2017, the title of the article was Regioselective synthesis of new 5-methyl-5H-pyrimido[4′,5′:4,5][1,3]thiazino [3,2-a]perimidines.HPLC of Formula: 626-48-2 And the article contains the following content:

A convenient and efficient regioselective synthesis of new pyrimido[4′,5′:4,5] [1,3]thiazino[3,2-a]perimidines I (R = pyrrolidin-1-yl, 4-methylpiperidin-1-yl, cyclohexylamino, methylamino, etc.) was described through intermol. heterocyclization of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine and 1H-perimidine-2(3H)-thione in short reaction times under mild conditions. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to pyrimido thiazino perimidine preparation regioselective, chloromethyl dichloro methylpyrimidine perimidinyl thione preparation heterocyclization, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On February 15, 2016, Ilyina, Margarita G.; Khamitov, Eduard M.; Ivanov, Sergey P.; Mustafin, Akhat G.; Khursan, Sergey L. published an article.Product Details of 626-48-2 The title of the article was Anions of uracils: N1 or N3? That is the question. And the article contained the following:

The relative stability of N1 and N3 anions of twelve 5,6-substituted uracils in aqueous solutions was studied in IEFPCM (SMD) – TPSSTPSS/6-311+G(d,p) approximation Specific solvation was simulated by the first hydrate shell of uracil and anions containing 5 water mols. Based on ΔGwater = G0(N3) – G0(N1), the series of relative stability was determined as: 5OH6MeU (-3.4) – 5OHU (-2.0) – 5NH2U (2.4) – U (3.5) – 5FU (4.5) – 5MeU (4.6) – 6MeU (4.6) – 5ClU (9.2) – 5BrU (9.5) – 5NO2U (18.6) – 6ClU (31.9) – 6FU (33.9), kJ/mol. The factors that determine the relative stability in the N1/N3 pair were identified. In the gas phase, the N1 anion is much more stable than the N3 anion: ΔGgas varies in the range from 23.3 (5OHU) to 80.0 (6FU) kJ/mol due to more efficient delocalization of excess charge over the uracil frame in the N1 anion, which was characterized using HOMA aromaticity indexes. The solvent makes the Gibbs energies of the N1 and N3 states much more close. Two reasons of the stabilizing effect of water can be distinguished. First, the aromaticity of N3 anions increases considerably in aqueous solutions, leading to almost complete equalization of HOMA indexes. Second, the polar solvent more efficiently stabilizes the more polar N3 states of the uracils studied. The effect of substituents on the relative stability ΔGwater was studied using the Hammett method. It was found that substituents with a strong (+R)-effect at position 5 decreased ΔGwater down to neg. values. Substituents at position 6 affect the relative stability of uracil anions by the inductive mechanism. In this case the formation of N1 anions becomes much more preferable than the formation of N3 anions. The mesomeric effect is weak in this case. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Product Details of 626-48-2

The Article related to uracil anion stability substituent effect solvent effect, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Product Details of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 31, 2022, Gimadieva, A. R.; Khazimullina, Yu. Z.; Abdrakhmanov, I. B.; Mustafin, A. G. published an article.Synthetic Route of 626-48-2 The title of the article was A Procedure for Preparing Effective Immunomodulators and Antioxidants: 5-Hydroxy-6-methyluracil and 5-Hydroxy-1,3,6-trimethyluracil. And the article contained the following:

5-Hydroxy-6-methyluracil is an acting agent of Oxymethyluracilum drug, an immunostimulator with a broad spectrum of pharmacol. activity. Its synthesis is based on the 6-methyluracil oxidation with (NH4)2S2O8 under the conditions of Elbs reaction. The Elbs oxidation of 6-methyluracil in the presence of metal phthalocyanine oxidation catalysts was studied. Conditions allowing the 5-hydroxy-6-methyluracil yield to be increased to 95% were found. The most active catalysts are Fe(II), Fe(III), and Co phthalocyanines. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Synthetic Route of 626-48-2

The Article related to hydroxymethyluracil hydroxytrimethyluracil preparation immunomodulator antioxidant, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Synthetic Route of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On November 5, 2021, Michalak, Olga; Cmoch, Piotr; Les, Andrzej; Cybulski, Marcin; Krzeczynski, Piotr; Trzcinska, Kinga; Miszta, Przemyslaw; Mehta, Pakhuri; Filipek, Slawomir published an article.SDS of cas: 626-48-2 The title of the article was Unexpected Reaction Products of Uracil and Its Methyl Derivatives with Acetic Anhydride and Methylene Chloride. And the article contained the following:

New acetyl derivatives of uracil, 6-methyluracil, and thymine were obtained in the course of an unconventional synthesis in methylene chloride. It was shown that products with the acetyloxymethyl fragment are formed according to a mechanism different from that for products with the acetyloxyethyl group. In particular, for uracil it was proven that the reaction with Ac2O, TEA, and CH2Cl2 leads to 1-acetyloxymethyluracil, where the N1 substituent is composed of the -CH2- fragment that originated from CH2Cl2 and the 1-acetyloxy moiety from Ac2O. The reaction of uracil with Ac2O, TEA, CH2Cl2, and DMAP leads to an acetyloxyethyl derivative in which the -CH2-CH2- fragment originates from TEA and the 1-acetyloxy moiety from Ac2O. A possible mechanism for the formation of new compounds was suggested and supported by the d. functional theory/B3LYP quantum mech. calculations New compounds (39 in total, including seven deuterated) were fully characterized by NMR and high-resolution mass spectrometry techniques. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).SDS of cas: 626-48-2

The Article related to uracil thymine methyluracil acetic anhydride dichloromethane reaction, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.SDS of cas: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Michalak, Olga; Cmoch, Piotr; Krzeczynski, Piotr; Cybulski, Marcin; Les, Andrzej published an article in 2019, the title of the article was A diversity of alkylation/acylation products of uracil and its derivatives: Synthesis and a structural study.COA of Formula: C5H6N2O2 And the article contains the following content:

Tert-Bu dicarbonate (Boc2O) and Et iodide react with uracil (U), thymine (T) and 6-methyluracil (6-MU) following routine procedures in pyridine/DMF solvents and with DMAP as the catalyst. Among 20 synthesized compounds, a derivative of 6-methyluracil substituted by the Boc-pyridine moiety at the C5 position appeared unexpectedly. The NMR spectra confirmed the mol. structure of all uracil derivatives Parallel quantum mech. DFT calculations supported the exptl. findings. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).COA of Formula: C5H6N2O2

The Article related to alkylation acylation uracil thymine methyluracil regioselectivity dft, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.COA of Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On May 31, 2014, Gimadieva, A. R.; Myshkin, V. A.; Mustafin, A. G.; Chernyshenko, Yu. N.; Borisova, N. S.; Zimin, Yu. S.; Abdrakhmanov, I. B. published an article.Reference of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Preparation and Antihypoxic Activity of Complexes of Uracil Derivatives with Dicarboxylic Acids. And the article contained the following:

Water-soluble low-toxicity complexes of 6-methyluracil and its derivatives with succinic acid and fumaric acids were prepared The synthesized complexes were tested for anti-hypoxic activity. The title compounds thus formed included butanedioic acid compound with 6-methyl-2,4(1H,3H)-pyrimidinedione (uracil-succinic acid complex), butanedioic acid compound with 5-hydroxy-6-methyl-2,4(1H,3H)-pyrimidinedione (oxymetacil-succinic acid complex), (2E)-2-butenedioic acid compound with 6-methyl-2,4(1H,3H)-pyrimidinedione (uracil-fumaric acid complex). etc. Butanedioic acid compound with 2-ethyl-6-methyl-3-pyridinol (1:1) (mexidol) was used as a reference compound The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Reference of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to succinic fumaric acid uracil complex preparation hypoxia treatment, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Reference of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia