Category: 626-48-2

Wang, Han; Wen, Kun; Wang, Le; Xiang, Ye; Xu, Xiaocheng; Shen, Yongjia; Sun, Zhihua published an article in 2012, the title of the article was Large-scale solvent-free chlorination of hydroxy-pyrimidines, -pyridines, -pyrazines and -amides using equimolar POCl3.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

Chlorination with equimolar POCl3 can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxypyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to chlorination hydroxy pyrimidine pyridine quinoxaline, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On October 31, 2013, Manivannan, C.; Sambathkumar, S.; Renganathan, R. published an article.Synthetic Route of 626-48-2 The title of the article was Interaction of acriflavine with pyrimidines: A spectroscopic approach. And the article contained the following:

The interaction of acriflavine with uracils was studied by using spectroscopic tools viz., UV-visible absorption, steady state and time resolved fluorescence measurements. The spectroscopic data were analyzed using Stern-Volmer equation to determine the quenching process. The bimol. quenching rate constant (kq), binding constant (K) and number of binding sites (n) were calculated at different temperature from the relevant fluorescence data. The exptl. results obtained from life-time measurement indicate that the quenching mechanism was static via the formation of ground state complex. The free energy change (ΔGet) for electron transfer process was calculated by Rehm-Weller equation. The existence of binding forces and the interactions of acriflavine with uracils were examined The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Synthetic Route of 626-48-2

The Article related to acriflavine pyrimidine spectroscopic, acriflavine, fluorescence quenching, uracils, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Synthetic Route of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On July 3, 2014, Sasidharanpillai, Swaroop; Loppnow, Glen R. published an article.HPLC of Formula: 626-48-2 The title of the article was Initial Excited-State Structural Dynamics of 5,6-Dimethyluracil from Resonance Raman Spectroscopy. And the article contained the following:

In order to understand the effect of Me substitution patterns on the initial excited-state structural dynamics of uracil derivatives, we measured the resonance Raman spectra of 5,6-dimethyluracil (5,6-DMU). The results show that the resonance Raman spectrum is a combination of that of 5-methyl- and 6-methyluracil. The resonance Raman excitation profiles (RREPs) and absorption spectrum are simulated with a self-consistent, time-dependent formalism to yield the excited-state slopes and broadening parameters. The initial excited-state structural dynamics occur primarily along the C5=C6 stretching mode, as expected, but with lesser excited-state slopes along each mode compared to 5-methyluracil and 6-methyluracil. This study along with previous experiments with different uracil derivatives show that the presence and positions of the Me groups seems to determine the partitioning of initial excited-state structural dynamics. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).HPLC of Formula: 626-48-2

The Article related to excited state structural dynamics dimethyluracil resonance raman spectra, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.HPLC of Formula: 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Grosmaire, L.; Delarbre, J.-L. published an article in 2012, the title of the article was Vibrational spectra of 6-methyluracil, 6-methyl-2-thiouracil and their deuterated analogues.Name: 6-Methylpyrimidine-2,4(1H,3H)-dione And the article contains the following content:

FTIR and Raman spectra of 6-methyluracil (6MU), 6-methyl-2-thiouracil (6M2TU) and the deuterated forms were recorded and analyzed in the regions 400-4000 cm-1 and 100-4000 cm-1, resp. The vibrational spectra are assigned using the frequency shifts upon N-deuteration, especially for bands due to NH modes. For both mols., the isotopic ratio frequency was calculated for each NH/ND vibrations. The sulfur substitution at C2 position in the 6MU mol. has an effect on the N1H and N3H vibrational frequencies. The assignments of C2=O and C4=O modes were supported by the absence of the C2=O group in the thio-derivative The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Name: 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to vibrational spectra methyluracil methylthiouracil deuterated analog, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Name: 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On March 31, 2017, Ostakhov, S. S.; Sultanbaev, M. V.; Ovchinnikov, M. Yu.; Kayumov, R. R.; Khursan, S. L. published an article.COA of Formula: C5H6N2O2 The title of the article was Spectral-luminescence and quantum-chemical study of the anionic forms of 5-fluorouracil. And the article contained the following:

A spectral-luminescence study of neutral (pH 7) and alk. (pH 11 and 14) aqueous solutions of the anticancer drugs 5-fluorouracil (FU) and tegafur has been performed. The fluorescence spectra of the N3- and N1-centered anions of 5-fluorouracil, its dianion, and the tegafur monoanion with emission maxima at wavelengths (λem) of 358, 372, 366, and 358 nm and photoluminescence quantum yields (φ) of 11.2 x 10-4, 35.1 x 10-4, 26.5 x 10-4, and 8.6 x 10-4, resp., have been recorded for the first time. The fluorescence characteristics of the FU anionic forms have been related to the magnetic shielding constant as one of the criteria of aromaticity. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).COA of Formula: C5H6N2O2

The Article related to fluorouracil tegafur uv fluorescence spectra ph effect, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.COA of Formula: C5H6N2O2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On June 28, 2019, Portalone, Gustavo published an article.Application of 626-48-2 The title of the article was 6-Methyluracil: a redetermination of polymorph (II). And the article contained the following:

6-Methyluracil, C5H6N2O2, exists in two crystalline phases: form (I), monoclinic, space group P21/c [Reck et al. (1988). Acta Crystalline A44, 417-421] and form (II), monoclinic, space group C2/c [Leonidov et al. (1993). Russ. J. Phys. Chem.67, 2220-2223]. The structure of polymorph (II) has been redetermined providing a significant increase in the precision of the derived geometric parameters. In the crystal, mols. form ribbons approx. running parallel to the c-axis direction through N-H···O hydrogen bonds. The radical differences observed between the crystal packing of the two polymorphs may be responsible in form (II) for an increase in the contribution of the polar canonical forms C-(O-)=N-H+ relative to the neutral canonical form C(=O)-N-H induced by hydrogen-bonding interactions. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Application of 626-48-2

The Article related to methyluracil polymorph redetn hydrogen bond crystal structure, Crystallography and Liquid Crystals: Crystallization and Recrystallization, Nucleation, Crystal Growth, Epitaxy, Nonepitaxial Film Deposition and other aspects.Application of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hua, XinZhong; Hua, LinQiang; Liu, XiaoJun published an article in 2016, the title of the article was The methyl- and aza-substituent effects on nonradiative decay mechanisms of uracil in water: a transient absorption study in the UV region.Related Products of 626-48-2 And the article contains the following content:

The nonradiative decay dynamics of photo-excited uracil (Ura) and its derivatives, i.e., thymine (5-methyluracil, Thy), 6-methyluracil (6-MU) and 6-azauracil (6-AU) in water, has been studied using a femtosecond transient absorption method. The mols. are populated in the lowest 1ππ* state by a pump pulse at 266 nm, and a broadband continuum in the deep UV region is then employed as the probe. The extension of the continuous UV probe down to 250 nm enables us to investigate comprehensively the population dynamics of the ground states for those mols. and to uncover the substituent effects on nonradiative decay dynamics of uracil. Vibrational cooling in the ground states of Ura, Thy and 6-MU has been directly observed for the first time, providing solid evidence of the ultrafast 1ππ* → S0 decay. In combination with the ground state bleaching signals, it is consolidated that their lowest 1ππ* state decays via two parallel pathways, i.e., 1ππ* → S0 and 1ππ* → 1nπ*. Moreover, the contribution of the 1ππ* → 1nπ* channel is found to be much smaller for Thy or 6-MU than for Ura. Different from methyl-substitution, the initial 1ππ* state of the aza-substituent 6-AU decays primarily to the 1nπ* state, while the 1ππ* → S0 channel can be negligible. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Related Products of 626-48-2

The Article related to methyluracilsubstituent effect transient nonradiative transition, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Radiation Chemistry and Photochemistry and other aspects.Related Products of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On February 5, 2021, Sambathkumar, S.; Manivannan, C.; Baskaran, S.; Kumar, R. Raj; Anbazhagan, V. published an article.Synthetic Route of 626-48-2 The title of the article was A study on the interaction of nile blue with Uracils: A spectroscopic and computational approach. And the article contained the following:

The present work focuses the investigation on fluorescence quenching of nile blue (NB) in presence of various substituted uracil mols. UV-Visible absorption studies signify the possibility of ground state complex formation between NB and uracil mols. The increase in concentration of quencher mols. greatly influences the emission spectra of NB. The bimol. quenching rate constant (kq) were calculated and found to depend on the position and electronic properties of substituent in quencher mols. Fluorescence quenching experiments were performed at different temperature to calculate the thermodn. parameters. The fluorescence lifetime measurements show that the quenching process proceeds through static quenching. The mechanism of fluorescence quenching includes the possibility of proton transfer. The bond dissociation enthalpy (BDE) reveals the release of H· from the quencher mols. The quencher mols. possess antioxidant activity and identified using deoxyribose degradation assay. The position of substituent and its electronic property are key features to address the antioxidant activity of uracil mols. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Synthetic Route of 626-48-2

The Article related to nile blue uracil fluorescence quenching kinetics antioxidant activity, antioxidant activity, fluorescence quenching, nile blue, uracil, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Synthetic Route of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

On December 31, 2014, Terent’ev, A. O.; Borisova, N. S.; Khamitov, E. M.; Zimin, Yu. S.; Mustafin, A. G. published an article.Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Experimental and quantum-chemical studies of the reactions of 6-methyluracil with succinic and fumaric acids. And the article contained the following:

Possible structures of 6-methyluracil complexes with succinic and fumaric acids were studied by quantum-chem. means. The possibility of complex formation occurring between 6-methyluracil and the acids in the ionized and nonionized states was evaluated. The form of the complexes containing the nonionized acid was found to dominate. The quantum-chem. calculation data were consistent with the exptl. results. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione

The Article related to methyluracil succinic fumaric acid hydrogen bonding chem shift, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.Quality Control of 6-Methylpyrimidine-2,4(1H,3H)-dione

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Qureshi, Wasay Mohiuddin Shaikh; Pratten, Margaret K. published an article in 2018, the title of the article was Chick embryonic cardiomyocyte micromass system for assessing developmental cardiotoxicity of drugs.Product Details of 626-48-2 And the article contains the following content:

Heart is the first mesodermal organ to develop and is sensitive to life-threatening toxic effects of drugs during development. A number of methods have been devised to study developmental cardiotoxic effects of drugs including micromass system. The micromass system involves the culture of primary embryonic cells and reestablishment of tissue system in vitro. In chick embryonic cardiomyocyte micromass system the chick heart cells are cultured in a small volume at a very high cell d. These cells form synchronized contracting foci. Addition of drugs to this system allows us to study the developmental cardiotoxic effects at mol. level. Using appropriate end points and mol. marker or adopting high-throughput screening, this method can further help to identify and avoid the use of cardiotoxic compounds during development. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Product Details of 626-48-2

The Article related to heart cardiomyocyte micromass system developmental cardiotoxicity vpa bpn, cardiomyocytes, chick, connexin43, developmental toxicology, micromass, reactive oxygen species, teratogens and other aspects.Product Details of 626-48-2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia