Category: 62968-37-0

Woodring, Jennifer L. et al. published their research in European Journal of Medicinal Chemistry in 2017 | CAS: 62968-37-0

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Formula: C8H10ClN3O

Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation was written by Woodring, Jennifer L.;Bachovchin, Kelly A.;Brady, Kimberly G.;Gallerstein, Mitchell F.;Erath, Jessey;Tanghe, Scott;Leed, Susan E.;Rodriguez, Ana;Mensa-Wilmot, Kojo;Sciotti, Richard J.;Pollastri, Michael P.. And the article was included in European Journal of Medicinal Chemistry in 2017.Formula: C8H10ClN3O This article mentions the following:

Human African trypanosomiasis (HAT) is a deadly disease in need of new chemotherapeutics that can cross into the central nervous system. The authors previously reported the discovery of (NEU-617), a small mol. with activity against T. brucei bloodstream proliferation. Further optimization of NEU-617 to improve the physicochem. properties (LogP, LLE, [1], and MPO score) [2] have led us to twelve sub-micromolar compounds, most importantly the headgroup variants I and II, and the linker variant III. Although these 3 compounds had reduced potency compared to NEU-617, they all had improved LogP, LLE and MPO scores. Cross-screening these analogs against other protozoan parasites uncovered IV with potent activity towards T. brucei, T. cruzi and L. major, while four others compounds showed activity towards P. falciparum D6. This reinforces the effectiveness of lead repurposing for the discovery of new protozoan disease therapeutics. In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0Formula: C8H10ClN3O).

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Formula: C8H10ClN3O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Hobbs, Heather et al. published their research in Journal of Medicinal Chemistry in 2019 | CAS: 62968-37-0

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Reference of 62968-37-0

Discovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway was written by Hobbs, Heather;Bravi, Gianpaolo;Campbell, Ian;Convery, Maire;Davies, Hannah;Inglis, Graham;Pal, Sandeep;Peace, Simon;Redmond, Joanna;Summers, Declan. And the article was included in Journal of Medicinal Chemistry in 2019.Reference of 62968-37-0 This article mentions the following:

4-(Pyrimidin-4-yl)morpholines are privileged pharmacophores for PI3K and PIKKs inhibition by virtue of the morpholine oxygen, both forming the key hydrogen bonding interaction and conveying selectivity over the broader kinome. Key to the morpholine utility as a kinase hinge binder is its ability to adopt a coplanar conformation with an adjacent aromatic core favored by the morpholine nitrogen nonbonding pair of electrons interacting with the electron deficient pyrimidine π-system. Few selective morpholine replacements have been identified to date. Herein we describe the discovery of a potent non-nitrogen containing morpholine isostere with the ability to mimic this conformation and its application in a potent selective dual inhibitor of mTORC1 and mTORC2 (29b). In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0Reference of 62968-37-0).

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. The aromatic compound pyrimidine, and its derivatives, are ubiquitous in nature. They are found in nucleic acids, vitamins, amino acids, antibiotics, alkaloids, and a variety of toxins. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Reference of 62968-37-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Singh, Jaybir et al. published their research in Chemistry & Biology Interface in 2012 | CAS: 62968-37-0

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Related Products of 62968-37-0

Synthesis of 4-amino substituted quinolines and their β-hematin inhibitory activity was written by Singh, Jaybir;Dhakarey, R. K. S.;Singh, Shiv Vardan;Suthar, Manish K.;Saxena, J. K.;Dwivedi, Anil Kumar. And the article was included in Chemistry & Biology Interface in 2012.Related Products of 62968-37-0 This article mentions the following:

In present study, new side chain modified 4-aminoquinoline derivatives and quinoline pyrimidine hybrids were synthesized and evaluated in vitro against β-hematin formation. Compounds 20, 21, 22, 23 have shown significant inhibitory activity against β-hematin formation. In the experiment, the researchers used many compounds, for example, 4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0Related Products of 62968-37-0).

4-(2-Chloropyrimidin-4-yl)morpholine (cas: 62968-37-0) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Related Products of 62968-37-0

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sources of common compounds: 62968-37-0

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 62968-37-0, 4-(2-Chloropyrimidin-4-yl)morpholine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 62968-37-0 ,Some common heterocyclic compound, 62968-37-0, molecular formula is C8H10ClN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 2-chloroheteroaryl compound 1 (0.50 mmol) in 1,4-dioxane (4.0 mL) were added pinacol boronate 3, 5, or 7 (0.60 mmol), Pd(OAc)2 (1.1 mg, 5.0 mumol), S-Phos (4.1 mg, 10.0 mumol), and 2 M LiOH solution (1.0 mL, 2.0 mmol) at room temperature, and the mixture was stirred for 30 min at 80 C under N2 atmosphere. The reaction was quenched by adding water, and then the mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed in vacuo, and the residue was purified by silica-gel column chromatography. The solvent was removed in vacuo, and the residue was triturated with Et2O to give biaryl compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 62968-37-0, 4-(2-Chloropyrimidin-4-yl)morpholine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Asano, Shigehiro; Kamioka, Seiji; Isobe, Yoshiaki; Tetrahedron; vol. 68; 1; (2012); p. 272 – 279;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 4-(2-Chloropyrimidin-4-yl)morpholine

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 62968-37-0, 4-(2-Chloropyrimidin-4-yl)morpholine.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 62968-37-0, name is 4-(2-Chloropyrimidin-4-yl)morpholine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C8H10ClN3O

General procedure: To a solution of 32 were added 2-chloropyrimidine intermediate (3a-3e, 3g) (1 equiv) and catalytic amount of 1N HCl in AcOH. The reaction mixture and a magnetic bar were sealed in the reaction vessel of an Anton paar monowave 300 and irradiated for 2 h at 160 C. The reaction mixture was concentrated in vacuo and then diluted with H2O or saturated aqueous NaHCO3. The aqueous layer was extracted with EtOAc, and the combined organic layers were dried over MgSO4 and then concentrated in vacuo. The residue was purified by flash column chromatography on silica gel.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 62968-37-0, 4-(2-Chloropyrimidin-4-yl)morpholine.

Reference:
Article; Jo, Jeyun; Kim, Sou Hyun; Kim, Heegyu; Jeong, Myeonggyo; Kwak, Jae-Hwan; Taek Han, Young; Jeong, Jee-Yeong; Jung, Young-Suk; Yun, Hwayoung; Bioorganic and Medicinal Chemistry Letters; vol. 29; 1; (2019); p. 62 – 65;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Share a compound : 4-(2-Chloropyrimidin-4-yl)morpholine

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 62968-37-0, 4-(2-Chloropyrimidin-4-yl)morpholine.

Electric Literature of 62968-37-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62968-37-0, name is 4-(2-Chloropyrimidin-4-yl)morpholine, molecular formula is C8H10ClN3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Toa stirred solution of appropriate alcohol (1.0 mmol) and suitablysubstituted heteroaryl halide (1.2 mmol) in dimethyl sulphoxide (5ml) was added and Cs2CO3(652 mg, 2.0 mmol) and mixture was stirred overnight at 80 C.The reaction mixture was cooled to room temperature and diluted withwater (20 ml). The mixture was extracted with ethyl acetate (2 x 50ml) and the combined organic extracts were washed with water (2 x 50ml) and dried (Na2SO4).The solvent was evaporated under reduced pressure and the residuethus obtained was purified by flash silica gel column chromatographyusing 13% methanol in chloroform as eluant to yield the desired heteroarylethers.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 62968-37-0, 4-(2-Chloropyrimidin-4-yl)morpholine.

Reference:
Article; Das, Sanjib; Shelke, Dnyaneshwar E.; Harde, Rajendra L.; Avhad, Vijayshree B.; Khairatkar-Joshi, Neelima; Gullapalli, Srinivas; Gupta, Praveen K.; Gandhi, Maulik N.; Bhateja, Deepak K.; Bajpai, Malini; Joshi, Ashwini A.; Marathe, Megha Y.; Gudi, Girish S.; Jadhav, Satyawan B.; Mahat, Mahamad Yunnus A.; Thomas, Abraham; Bioorganic and Medicinal Chemistry Letters; vol. 24; 15; (2014); p. 3238 – 3242;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sources of common compounds: 4-(2-Chloropyrimidin-4-yl)morpholine

The chemical industry reduces the impact on the environment during synthesis 62968-37-0, I believe this compound will play a more active role in future production and life.

Application of 62968-37-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62968-37-0, name is 4-(2-Chloropyrimidin-4-yl)morpholine, molecular formula is C8H10ClN3O, molecular weight is 199.64, as common compound, the synthetic route is as follows.

General procedure: Compound 12 (0.088g, 0.173mmol), a 2M solution of sodium carbonate (0.520mL, 1.039mmol) in water, tetrakis(triphenylphosphine)palladium(0) (0.014g, 0.012mmol), dimethoxyethane (2mL), ethanol (1.3mL) and the respective morpholine substituted pyrimidine (0.190mmol) were added together and heated to 85C for 12h. The resulting mixture was concentrated under reduced pressure and the product was separated by silica column chromatography (hexanes/ethyl acetate) and purified by reverse phase chromatography (water/acetonitrile).

The chemical industry reduces the impact on the environment during synthesis 62968-37-0, I believe this compound will play a more active role in future production and life.

Reference:
Article; Woodring, Jennifer L.; Bachovchin, Kelly A.; Brady, Kimberly G.; Gallerstein, Mitchell F.; Erath, Jessey; Tanghe, Scott; Leed, Susan E.; Rodriguez, Ana; Mensa-Wilmot, Kojo; Sciotti, Richard J.; Pollastri, Michael P.; European Journal of Medicinal Chemistry; vol. 141; (2017); p. 446 – 459;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia