Category: 6297-80-9

Huebsch, Walter’s team published research in Helvetica Chimica Acta in 1989 | CAS: 6297-80-9

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 4,6-Dichloropyrimidin-2(1H)-one

Application In Synthesis of 4,6-Dichloropyrimidin-2(1H)-oneOn June 14, 1989, Huebsch, Walter; Pfleiderer, Wolfgang published an article in Helvetica Chimica Acta. The article was 《Pteridines. Part XLI. Synthesis and properties of 6,7,8-trimethyl-4-thiolumazine》. The article mentions the following:

The first representative I of the 8-substituted 4-thiolumazine series has been synthesized. 4,6-Dichloropyrimidin-2(1H)-one was converted into 4-chloro-6-(methylamino)pyrimidin-2(1H)-one, then the Cl atom was displaced by the thioxo group followed by a coupling reaction with ClC6H4N2+Cl- to introduce the necessary N-function into the 5-position. Reduction of the p-chlorophenylazo group leads to 6-(methylamino)-4-thiouracil-5-amine which on condensation with diacetyl gives I. The phys. properties of I are compared with the 2-thio analog and with 6,7,8-trimethyllumazine indicating that I possesses the highest acidity and the longest UV absorption. The experimental process involved the reaction of 4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9Application In Synthesis of 4,6-Dichloropyrimidin-2(1H)-one)

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 4,6-Dichloropyrimidin-2(1H)-one

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kazimierczuk, Z.’s team published research in Acta Biochimica Polonica in 1972 | CAS: 6297-80-9

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 6297-80-9

In 1972,Acta Biochimica Polonica included an article by Kazimierczuk, Z.; Lipski, M.; Shugar, D.. Recommanded Product: 6297-80-9. The article was titled 《Intermediates in the synthesis of purines and pteridines. Selective hydrolysis of chloropyrimidines》. The information in the text is summarized as follows:

Alk. hydrolysis of 2,4,6-trichloropyrimidine gave 4,6-dichloro-2-hydroxypyrimidine (I), which gave 6-chlorouracil on acid hydrolysis. Treatment of I with NH3 in anhydrous EtOH gave 4,6-diamino-2-hydroxypyrimidine, but Me2NH in anhydrous EtOH gave 4,6-bis(methylamino)-2-hydroxypyrimidine. Alk. hydrolysis of 2,4-dichloropyrimidine gave 4-chloro-2-hydroxypyrimidine (II), which reacted with NH3 in anhydrous EtOH to give cytosine. Treatment of II with Na and anhydrous EtOH gave 4-ethoxy-2-hydroxypyrimidine. The experimental process involved the reaction of 4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9Recommanded Product: 6297-80-9)

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Recommanded Product: 6297-80-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Seganish, W. Michael’s team published research in ACS Medicinal Chemistry Letters in 2015 | CAS: 6297-80-9

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Computed Properties of C4H2Cl2N2O

Seganish, W. Michael; Fischmann, Thierry O.; Sherborne, Brad; Matasi, Julius; Lavey, Brian; McElroy, William T.; Tulshian, Deen; Tata, James; Sondey, Christopher; Garlisi, Charles G.; Devito, Kristine; Fossetta, James; Lundell, Daniel; Niu, Xiaoda published their research in ACS Medicinal Chemistry Letters on August 13 ,2015. The article was titled 《Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors》.Computed Properties of C4H2Cl2N2O The article contains the following contents:

We report the identification and synthesis of a series of aminopyrimidin-4-one IRAK4 inhibitors. Through high throughput screening, an aminopyrimidine hit was identified and modified via structure enabled design to generate a new, potent, and kinase selective pyrimidin-4-one chemotype. This chemotype is exemplified by compound 16 (XVI), which has potent IRAK4 inhibition activity (IC50 = 27 nM) and excellent kinase selectivity (>100-fold against 99% of 111 tested kinases), and compound 31 (XXXI), which displays potent IRAK4 activity (IC50 = 93 nM) and good rat bioavailability (F = 42%). In addition to this study using 4,6-Dichloropyrimidin-2(1H)-one, there are many other studies that have used 4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9Computed Properties of C4H2Cl2N2O) was used in this study.

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Computed Properties of C4H2Cl2N2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Huebsch, Walter’s team published research in Biochemical and Clinical Aspects of Pteridines in 1987 | CAS: 6297-80-9

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.HPLC of Formula: 6297-80-9

In 1987,Biochemical and Clinical Aspects of Pteridines included an article by Huebsch, Walter. HPLC of Formula: 6297-80-9. The article was titled 《Synthesis and biological activity of 8-substituted thiolumazines》. The information in the text is summarized as follows:

I (X and Y = O or S, R = Me, CH2CH2OH, Ph, or ribityl were prepared as precursors and converted to thiolumazine derivatives II (X and Y = O or S, R = Me, CH2CH2OH, Ph, or ribityl, R1 and R2 = H, Me, OH, or Ph) were prepared and then structure-activity relation discussed with regard to enzyme inhibition in chemotherapy. The 2-oxo group was important for enzyme substrate interaction. Replacement by S had a strong neg. effect. In addition to this study using 4,6-Dichloropyrimidin-2(1H)-one, there are many other studies that have used 4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9HPLC of Formula: 6297-80-9) was used in this study.

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.HPLC of Formula: 6297-80-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Giordanetto, Fabrizio’s team published research in Bioorganic & Medicinal Chemistry Letters in 2012 | CAS: 6297-80-9

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Product Details of 6297-80-9

Product Details of 6297-80-9On November 1, 2012 ,《Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Giordanetto, Fabrizio; Waallberg, Andreas; Ghosal, Saswati; Iliefski, Tommy; Cassel, Johan; Yuan, Zhong-Qing; von Wachenfeldt, Henrik; Andersen, Soeren M.; Inghardt, Tord; Tunek, Anders; Nylander, Sven. The article conveys some information:

Structure-based evolution of the original fragment leads resulted in the identification of 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, (S)-21, a potent, selective phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor with favorable in vivo antiplatelet effect. Despite its antiplatelet action, (S)-21 did not significantly increase bleeding time in dogs. Addnl., due to its enhanced selectivity over p110α, (S)-21 did not induce any insulin resistance in rats. In addition to this study using 4,6-Dichloropyrimidin-2(1H)-one, there are many other studies that have used 4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9Product Details of 6297-80-9) was used in this study.

4,6-Dichloropyrimidin-2(1H)-one(cas: 6297-80-9) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Product Details of 6297-80-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Brief introduction of 4,6-Dichloropyrimidin-2(1H)-one

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6297-80-9, its application will become more common.

Related Products of 6297-80-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6297-80-9 as follows.

General procedure: #10;4,6-dichloropyrimidin-2(1H)-one (0.24 mmol) and the amine (0.24 mmol) was dissolved in NMP (1 ml) in a microwave vial. The vial was capped and heated at 120 °C for 15 min in a single node microwave reactor. Morpholine (7.5 mmol) was added and the mixture was heated at 120 °C for 30 min. The reaction mixture was worked up with DCM (3 ml) and brine (1 ml) and filtered through a phase separator. The compound was purified with HPLC using FractionLynx I instrument, Mobilphase: gradient 5-95percent ACN in 0.1 M HCO2H, pH3, Column: Sunfire Prep C18 5m OBD 19*150 mm to give the product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6297-80-9, its application will become more common.

Reference:
Article; Giordanetto, Fabrizio; Wallberg, Andreas; Ghosal, Saswati; Iliefski, Tommy; Cassel, Johan; Yuan, Zhong-Qing; Von Wachenfeldt, Henrik; Andersen, Soren M.; Inghardt, Tord; Tunek, Anders; Nylander, Sven; Bioorganic and medicinal chemistry letters; vol. 22; 21; (2012); p. 6671 – 6676,6;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

24-Sep-21 News Share a compound : 6297-80-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6297-80-9, 4,6-Dichloropyrimidin-2(1H)-one, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 6297-80-9, 4,6-Dichloropyrimidin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 4,6-Dichloropyrimidin-2(1H)-one, blongs to pyrimidines compound. Quality Control of 4,6-Dichloropyrimidin-2(1H)-one

General procedure: #10;4,6-dichloropyrimidin-2(1H)-one (0.24 mmol) and the amine (0.24 mmol) was dissolved in NMP (1 ml) in a microwave vial. The vial was capped and heated at 120 °C for 15 min in a single node microwave reactor. Morpholine (7.5 mmol) was added and the mixture was heated at 120 °C for 30 min. The reaction mixture was worked up with DCM (3 ml) and brine (1 ml) and filtered through a phase separator. The compound was purified with HPLC using FractionLynx I instrument, Mobilphase: gradient 5-95percent ACN in 0.1 M HCO2H, pH3, Column: Sunfire Prep C18 5m OBD 19*150 mm to give the product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6297-80-9, 4,6-Dichloropyrimidin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Article; Giordanetto, Fabrizio; Wallberg, Andreas; Ghosal, Saswati; Iliefski, Tommy; Cassel, Johan; Yuan, Zhong-Qing; Von Wachenfeldt, Henrik; Andersen, Soren M.; Inghardt, Tord; Tunek, Anders; Nylander, Sven; Bioorganic and medicinal chemistry letters; vol. 22; 21; (2012); p. 6671 – 6676,6;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

24-Sep-21 News Share a compound : 6297-80-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6297-80-9, 4,6-Dichloropyrimidin-2(1H)-one, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 6297-80-9, 4,6-Dichloropyrimidin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 4,6-Dichloropyrimidin-2(1H)-one, blongs to pyrimidines compound. Quality Control of 4,6-Dichloropyrimidin-2(1H)-one

General procedure: #10;4,6-dichloropyrimidin-2(1H)-one (0.24 mmol) and the amine (0.24 mmol) was dissolved in NMP (1 ml) in a microwave vial. The vial was capped and heated at 120 °C for 15 min in a single node microwave reactor. Morpholine (7.5 mmol) was added and the mixture was heated at 120 °C for 30 min. The reaction mixture was worked up with DCM (3 ml) and brine (1 ml) and filtered through a phase separator. The compound was purified with HPLC using FractionLynx I instrument, Mobilphase: gradient 5-95percent ACN in 0.1 M HCO2H, pH3, Column: Sunfire Prep C18 5m OBD 19*150 mm to give the product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6297-80-9, 4,6-Dichloropyrimidin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Article; Giordanetto, Fabrizio; Wallberg, Andreas; Ghosal, Saswati; Iliefski, Tommy; Cassel, Johan; Yuan, Zhong-Qing; Von Wachenfeldt, Henrik; Andersen, Soren M.; Inghardt, Tord; Tunek, Anders; Nylander, Sven; Bioorganic and medicinal chemistry letters; vol. 22; 21; (2012); p. 6671 – 6676,6;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Extracurricular laboratory: Synthetic route of 6297-80-9

The synthetic route of 6297-80-9 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 6297-80-9, 4,6-Dichloropyrimidin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 4,6-Dichloropyrimidin-2(1H)-one, blongs to pyrimidines compound. Quality Control of 4,6-Dichloropyrimidin-2(1H)-one

General procedure: #10;4,6-dichloropyrimidin-2(1H)-one (0.24 mmol) and the amine (0.24 mmol) was dissolved in NMP (1 ml) in a microwave vial. The vial was capped and heated at 120 ¡ãC for 15 min in a single node microwave reactor. Morpholine (7.5 mmol) was added and the mixture was heated at 120 ¡ãC for 30 min. The reaction mixture was worked up with DCM (3 ml) and brine (1 ml) and filtered through a phase separator. The compound was purified with HPLC using FractionLynx I instrument, Mobilphase: gradient 5-95percent ACN in 0.1 M HCO2H, pH3, Column: Sunfire Prep C18 5m OBD 19*150 mm to give the product.

The synthetic route of 6297-80-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Giordanetto, Fabrizio; Wallberg, Andreas; Ghosal, Saswati; Iliefski, Tommy; Cassel, Johan; Yuan, Zhong-Qing; Von Wachenfeldt, Henrik; Andersen, Soren M.; Inghardt, Tord; Tunek, Anders; Nylander, Sven; Bioorganic and medicinal chemistry letters; vol. 22; 21; (2012); p. 6671 – 6676,6;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia