Category: 6299-25-8

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6299-25-8, name is 4,6-Dichloro-2-(methylthio)pyrimidine, the common compound, a new synthetic route is introduced below. Computed Properties of C5H4Cl2N2S

Reference Example 71 Production of ethyl 4,6-dichloro-2-(methylsulfanyl)pyrimidine-5-carboxylate Under an argon atmosphere, to a solution of diisopropylamine (15.7 mL, 112 mmol) in THF (70 mL) was added dropwise butyllithium (1.6M hexane solution, 70 mL, 112 mmol) at -78C. The mixture was stirred at 0C for 30 min and cooled to -78C. A solution of 4,6-dichloro-2-(methylsulfanyl)pyrimidine (14.12 g, 72.4 mmol) in THF (20 mL) was added dropwise thereto, and the mixture was stirred at – 78C for 1 hr. A solution of ethyl chlorocarbonate (13.9 mL, 145 mmol) in THF (20 mL) was added dropwise thereto, and the mixture was stirred at -78C for 30 min, and then at 0C for 30 min. Water was added thereto, and the mixture was extracted twice with ethyl acetate. The extract was washed with brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluate, hexane:ethyl acetate=100:0?90:10) to give the title compound (13.28 g, 69%) as a colorless solid.

The synthetic route of 6299-25-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2471793; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 6299-25-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6299-25-8, name is 4,6-Dichloro-2-(methylthio)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 4, 6-Dichloro-2-methylsulfanyl-pyrimidine 0103 (5.0 g, 25.6 mmol) in CH2Cl2 (15 mL) at 0 0C was added meta-chloroperoxybenzoic acid (11.06 g, 64.1 mmol) over a period of 20 minutes. The reaction was allowed to warm to room temperature and stirred for 2.5 hours. The mixture was filtrated and the filtrate was concentrated. The resulting residue was washed with saturated Na2CO3 solution and ether to form a white solid which was dried to obtain the title compound 0104 (2.6g, 44%): LCMS: 227 [M+l]+; 1H NMR (CDCl3) delta 3.4 (s, 3H), 7.75 (s, IH).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidine.

Reference:
Patent; CURIS, INC.; WO2009/86012; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6299-25-8, name is 4,6-Dichloro-2-(methylthio)pyrimidine, the common compound, a new synthetic route is introduced below. Recommanded Product: 6299-25-8

Example 2C4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylic acid; To a solution of diisopropylamine (20 mL, 142 mmol) in tetrahydrofuran (170 mL) at -78C was added n-butyl lithium (55.4 mL, 2.5M solution in hexane, 138 mmol). The mixture was stirred at -78C for 1 hour and was charged with a solution of the product of Example 2B (18 g, 92.3 mmol) in tetrahydrofuran (40 mL). After stirring at -78C for 3 hours, dry carbon dioxide was bubbled into the mixture for 30 minutes, followed by the addition of water at low temperature. The mixture was allowed to warm to ambient temperature and the mixture was adjusted to pH = 1 by addition of 2M hydrochloric acid. The mixture was extracted with ethyl acetate (3 x 300 mL) and the combined organic layers were dried over sodium sulfate, filtered and concentrated. The residue was washed with toluene to obtain the title compound. MS: 239 (M+H+).

The synthetic route of 6299-25-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT LABORATORIES; VASUDEVAN, Anil; PENNING, Thomas; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; WU, Fengchun; SHEN, Yan; LIU, Cuihua; ZOU, Zhenguang; WO2012/97478; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H4Cl2N2S, blongs to pyrimidines compound. COA of Formula: C5H4Cl2N2S

Example 42a3-[6-chloro-2-(methylthio)pyrimidin-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; A mixture of 4,6-dichloro-2-(methylthio)pyrimidine (0.558 g, 2.86 mmol), Example 1c (1 g, 2.60 mmol), 2M aqueous Cs2CO3 solution (1.30 mL, 2.60 mmol), 1,2-dimethoxyethane/dimethylfomamide (9/l, 12 mL), and tetrakis(triphenylphosphine)palladium (0.120 g, 0.104 mmol) was evacuated and purged with nitrogen. The mixture was heated at 80 C. under nitrogen for 30 minutes, then cooled to room temperature. Solids were collected by filtration, washed with hexanes, and dried under vacuum to give the title compound (606 mg, 56% yield).

The synthetic route of 6299-25-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT LABORATORIES; US2011/15173; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6299-25-8, name is 4,6-Dichloro-2-(methylthio)pyrimidine. A new synthetic method of this compound is introduced below., Safety of 4,6-Dichloro-2-(methylthio)pyrimidine

To a stirred solution of 4,6-dichloro-2- (methylthio)pyrimidine (50 g, 0.26 mol) in dichloromethane (1 L) at 00C was added meta-chloroperoxybenzoic acid (143.6 g, 0.64 mol) over a period of 20 minutes. The solution was allowed to warm to room temperature and was stirred for 4 hours. The mixture was diluted with dichloromethane (1.5 L) and then treated sequentially with 50% Na2S2O3 / NaHCO3 solution (2 x 200 ml), sat. NaHCO3 solution (4 x 300 ml), and brine (200 ml) then dried (MgSO4). The solvent was removed in vacuo to afford an off-white solid, which was redissolved in EtOAc (IL) and treated sequentially with sat. NaHCO3 solution (3 x 300 ml), and brine (100 ml) then dried (MgSO4). The solvent was removed EPO in vacuo to afford the title compound (A) as a white solid (55.6 g, 96% yield). 1H NMR CDCl3 delta 3.40 (3H5 s, CH3), 7.75 (IH. s. ArH).

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Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2007/14250; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 6299-25-8, Adding some certain compound to certain chemical reactions, such as: 6299-25-8, name is 4,6-Dichloro-2-(methylthio)pyrimidine,molecular formula is C5H4Cl2N2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6299-25-8.

4,6-Dichloro-2-(methylthio)pyrimidine (10 g, 51 mmol) was dissolved in a mixtureButanol/NH4OH (100 ml/50 ml). It was stirred for V2 h in a sealed tube (internal pressure 42 PSI) heated to 8O0C. After cooling to RT, the organic layer was separated, dried over MgSO4 and concentrated. 6.0 g (66%) of the desired intermediate was obtained as a colourless solid; mlz (ES+) 175, 177 (MH+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2007/141571; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 6299-25-8 ,Some common heterocyclic compound, 6299-25-8, molecular formula is C5H4Cl2N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4,6-dichloro-2-(methylthio)pyrimidine (0.7?g, 3.608?mmol) was dissolved in dichloromethane (15?mL), cooled to 0?C and meta-Chloroperoxybenzoic acid (m-CPBA) was added (1.55?g, 9.011?mmol) portion wise to the reaction mixture at the same temperature. After addition, the reaction mixture was allowed to stir for 4?h at room temperature. Then the reaction mass was quenched with an aqueous solution of sodium thiosulphate (11?mL) and extracted with dichloromethane (2?*?10?mL). Combined organic layer was washed with saturated aqueous NaHCO3 solution (15?mL), brine solution (7?mL), dried over anhydrous MgSO4, filtered and the filtrate was evaporated under reduced pressure to afford 4,6-dichloro-2-(methylsulfonyl)pyrimidine (0.65?g, 80.20%) as off-white solid ( Scheme -1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Murthy, P. Krishna; Valverde, Clodoaldo; Suneetha; Armakovi?, Stevan; Armakovi?, Sanja J.; Rani, N. Usha; Naidu, N. Venkatasubba; Journal of Molecular Structure; vol. 1186; (2019); p. 263 – 275;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6299-25-8, blongs to pyrimidines compound. Application In Synthesis of 4,6-Dichloro-2-(methylthio)pyrimidine

(1) n-Butyl lithium(1.7M hexane solution, 295 mL) was added dropwise to a solution of diisopropylamine(47.7 g) in THF(1.4 L) at -78C under nitrogen atmosphere for 30 minutes and stirred for additional 30 minutes. A solution of 4,6-dichloro-2-methylsulfanyl-pyrimidine(40.0 g) in THF(200 mL) was added dropwise to the reaction solution for an hour and stirred for an additional hour. The reaction solution was poured into dry ice(800 g) slowly and the mixture was stirred for 2 hours. Hydrochloric acid(1N) was added slowly, ethyl acetate was added thereto and the mixture was washed with water and brine. The aqueous layer was extracted with ethyl acetate, the combined organic layer was dried over magnesium sulfate and the solvent was distilled away. Hexane was added and the solid was triturated and dried to give 4,6-dichloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid(45.51 g) as a pale brown solid. APCI-MS(m/e):237/239[M-H]-.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6299-25-8, its application will become more common.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP1970373; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia