Category: 6299-87-2

Synthetic Route of 6299-87-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6299-87-2, name is 6-Hydroxypyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below.

Into a 5-L 4-necked round-bottom flask, purged and maintained with an inert atmosphere of nitrogen, was placed 6-hydroxypyrimidine-4-carboxylic acid (100 g, 713.79 mmol, 1.00 equiv) and methanol (2000 mL), followed by the addition of thionyl chloride (210 g, 2.50 equiv) dropwise with stirring at 0°C. The resulting solution was stirred at 30°C for 1 day and concentrated under vacuum to afford 1 15 g (crude) of methyl 6-hydroxypyrimidine-4-carboxylate as an off-white solid. LCMS [M+H]+ 155.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6299-87-2, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; VERMA, Vishal; SHORE, Daniel; VOLGRAF, Matthew; ESTRADA, Anthony A.; LYSSIKATOS, Joseph; (153 pag.)WO2018/15410; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6299-87-2, name is 6-Hydroxypyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below., Application In Synthesis of 6-Hydroxypyrimidine-4-carboxylic acid

The 6-chloropyrimidine-4-carbonyl chloride used as a starting material was prepared as follows: Phosphorus oxychloride (10 ml) was added carefully to a stirred sample of 6-hydroxypyrimidine-4-carboxylic acid (1 g) and the mixture was heated to reflux for 16 hours. Phosphorus pentachloride (5.8 g) was added and the resultant mixture was heated to reflux for a further 16 hours. The excess of phosphorus oxychloride was evaporated under reduced pressure and the residue was distilled. A solid formed in the cooling condenser. There was thus obtained 6-chloropyrimidine-4-carboxylic acid (0.5 g); NMR (DMSOd6) 8.07 (s, 1H), 9.2 (s, 1H), 14.0-14.3 (br s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6299-87-2, 6-Hydroxypyrimidine-4-carboxylic acid.

Reference:
Patent; Astra Zeneca AB; US6455520; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6299-87-2, 6-Hydroxypyrimidine-4-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

6-hydroxypyrimidine-4-carboxylic acid 1.00 g (7.14 mmol),30 ml of methylene chloride, 3.60 g (28.4 mmol) of oxalyl chloride and 0.05 g (0.68 mmol) of N, N-dimethylformamide were added to 1.00 g (7.14 mmol), and the mixture was heated under reflux for 3 hours. Then, the reaction solution was concentrated under reduced pressure. To the obtained residue was added 30 ml of methylene chloride, 0.70 g (7.18 mmol) of O-ethylhydroxylammonium chloride and 1.45 g (14.3 mmol) of triethylamine were added under ice cooling, and the mixture was stirred at room temperature for 3 hours . Then, the reaction solution was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography Further purification gave 0.79 g (3.92 mmol, yield 55percent) of 6-chloro-N-ethoxypyridine-4-carboxamide.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6299-87-2, 6-Hydroxypyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; NIPPON SODA COMPANY LIMITED; ITO, SYUICHI; AMANO, TOMOHIRO; IPPOSHI, JUNJI; KOUBORI, SHINYA; (44 pag.)JP2016/30742; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 6299-87-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6299-87-2, name is 6-Hydroxypyrimidine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Step 2: 6-chloropyrimidine-4-carboxylic acid chloride 50.0 g (0.35 mol) 6-hydroxypyrimidine-4-carboxylic acid were taken and 500 mL phosphorus oxychloride were added. Then 150 g (0.72 mol) phosphorus pentachloride were added batchwise with stirring. The reaction mixture was refluxed for 5 h. The phosphorus oxychloride was distilled off and the residue was purified by vacuum distillation through a column. Yield: 51.9 g (83% of th.) MS: m/z=176/178/180 (M)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6299-87-2, 6-Hydroxypyrimidine-4-carboxylic acid.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/21500; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia