Adding a certain compound to certain chemical reactions, such as: 63155-11-3, Ethyl 2-(pyrimidin-2-yl)acetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C8H10N2O2, blongs to pyrimidines compound. HPLC of Formula: C8H10N2O2
Reference Production Example 12 1.97 g of a compound of the formula (24-i), 1.84 g of ethyl (2-pyrimidinyl) acetate, 4.08 g of sodium ethoxide (20% ethanol solution) and 35 ml of ethanol were mixed. The mixture was stirred for 6 hours under reflux with heating. The reaction mixture was allowed to cool to room temperature, the, to the reaction mixture were added ice and 6 ml of 1.71 mol/L hydrochloric acid sequentially, and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, then, mostly concentrated under reduced pressure. The resultant solid was collected by filtration, and the solid was dried under reduced pressure, to obtain 1.63 g of 5-(4-chlorophenyl)-6-methyl-4-(2-pyrimidinyl)-2H-pyridazin-3 -one. 1H-NMR (CDCl3 + DMSO-d6, TMS) delta (ppm): 2.13 (3 H, s), 7.07 (2 H, d, J=8.8 Hz), 7.13 (1 H, t, J=5.1 Hz), 7.23 (2 H, d, J=8.8 Hz), 8.66 (2 H, d, J=5.1 Hz), 12.00 (1 H, br s)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,63155-11-3, Ethyl 2-(pyrimidin-2-yl)acetate, and friends who are interested can also refer to it.
Reference:
Patent; Sumitomo Chemical Company, Limited; EP1958946; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia