Category: 6320-15-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine, the common compound, a new synthetic route is introduced below. COA of Formula: C6H7ClN2O2

4-(furan-2-yl)-2,6-dimethoxypyrimidine According to the general procedure, a mixture of 6-chloro-2,4-dimethoxypyrimidine (175 mg, 1 .00 mmol), 2-furanboronic acid (168 mg, 1 .50 mmol), (7i-crotyl)Pd(XPhos)CI (14 mg, 0.02 mmol), 2 mL THF, and 4 mL of 0.5 M aqueous K3P04 are stirred at room temperature for 1 hour. The crude material is chromatographed on silica gel with a gradient of 0 – 10 % EtOAc/hexanes as the eluent to give 194 mg (0.94 mmol, 94 %) of 4-(furan-2-yl)-2,6-dimethoxypyrimidine as a colorless solid. H NMR (400 MHz, CDCI3, delta): 7.53 (dd, J = 0.9 Hz, 1 .9 Hz, 1 H), 7.19 (dd, J = 0.7 Hz, 3.5 Hz, 1 H), 6.69 (s, 1 H), 6.53 (dd, J = 1 .7 Hz, 3.4 Hz, 1 H) 4.02 (s, 3H), 3.99 (s, 3H). l3C NMR (100 MHz, CDCI3, delta): 172.6, 165.6, 157.4, 152.2, 144.6, 1 12.3, 1 1 1 .9, 95.0, 54.8, 54.0. Anal. Calcd. for C10H10N2O3: C, 58.25; H, 4.89; N, 13.59. Found: C, 58.19; H, 4.72; N, 13.42

The synthetic route of 6320-15-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JOHNSON MATTHEY PUBLIC LIMITED COMPANY; COLACOT, Thomas; CHOW, Ruishan; JON DEANGELIS, Andrew; WO2015/189554; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 6320-15-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine. A new synthetic method of this compound is introduced below.

Step b: 2.6-Dimethoxypyrimidin-4-ol (18b); A suspension of 4-chloro-2,6-dimethoxy-pyrimidine (4.9 g, 28 mmol), DABCO (6.4 g, 57 mmol) and potassium carbonate (13.8 g, 100 mmol) was refluxed in water (150 ml) for one hour. The mixture was cooled acidified with 5% citric acid and extracted three times with ethyl acetate and three times with DCM with about 105 THF and 10% MeOH. The combined organic phases were dried and evaporated which gave the title compound (1.5 g, 34%), (M+H)+ 1 157.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6320-15-6, 4-Chloro-2,6-dimethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; MEDIVIR AB; WO2008/95999; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 6320-15-6 , The common heterocyclic compound, 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine, molecular formula is C6H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The 3,5-dimethylbenzene acetonitrile (725mg, 5mmol) was dissolved in 40ml DMF, underice-cooling conditions , added NaH (120mg, 5mmol). Under the protection of nitrogen gas stirred for 1 hour, the system changed from colorless to red winecolor, afterwards added 2,4-dimethoxy-6-chloropyrimidine (924mg,5mmol). At theroom temperature stirred for 48 h, pass the air into the reaction system and stirringwas continued for 48~72 hours. The reaction was stopped , after the solvent wasdistilled off under reduced pressure added 200ml water to adjust the PH toneutral with hydrochloric acid. Extracted with Ethyl acetate (100ml X 3),combined the organic phases and for drying added Anhydrous sodium sulfate.Purified through column chromatography (petroleum ether / ethyl acetate) to obtaina pale yellow solid. Yield 89%; melting point. 110-112 C

The synthetic route of 6320-15-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Peking University; LIU, JUNYI; LI, CHAO; WANG, XIAOWEI; ZHANG, ZHILI; GUO, YING; TIAN, CHAO; (12 pag.)CN104119283; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 6320-15-6 ,Some common heterocyclic compound, 6320-15-6, molecular formula is C6H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparatory Example 74 4, 6-Dimethoxy-3- (perfluoroethyl) -1H-pyrazolo [3, 4-d] pyrimidine (Scheme 13) Step 1. 1- (4-Chloro-2, 6-dimethoxypyrimidin-5-yl) -2, 2, 3, 3, 3-pentafluoropropan-1-oneTo a stirred solution of 4-chloro-2, 6-dimethoxypyrimidine (0.50 g, 2.86 mmol) in THF (30 mL) at -30under N2was added 2, 2, 6, 6-tetramethylpiperidinylmagnesium chloride lithium chloride complex (1.5 M in THF, 1.4 mL, 2.86 mmol) dropwise. The reaction solution was stirred at -30for 2 h whereupon a copper (I) cyanide di (lithium chloride) complex solution (1 M in THF, 2.86 mL, 2.86 mmol) was added dropwise. The reaction mixture was stirred for an additional 30 min at -30whereupon 2, 2, 3, 3, 3-pentafluoropropanoic anhydride (1.78 g, 5.7 mmol) was added. The reaction mixture allowed to gradually warm to RT and was stirred for 16 h. The resulting mixture was quenched with sat. aq. sodium bicarbonate (50 mL) , diluted with water (50 mL) and extracted with EtOAc (3 x 50 mL) . The combined organic layers were washed with brine (1 x 30 mL) , dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (0-10ethyl acetate in hexanes) to afford the title compound as an oil.1H NMR (400 MHz, CDCl3) delta: 4.11 (s, 3H) , 4.10 (s, 3H) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6320-15-6, 4-Chloro-2,6-dimethoxypyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO. LTD.; SHEN, Dong-Ming; DWYER, Michael; SINZ, Christopher J.; WANG, Deping; STACHEL, Shawn; PAONE, Daniel; NOMLAND, Ashley; BERGER, Richard; CHEN, Yili; QIAN, Yimin; XU, Shimin; HU, Chunmei; (212 pag.)WO2016/192083; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 6320-15-6 ,Some common heterocyclic compound, 6320-15-6, molecular formula is C6H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparatory Example 74 4, 6-Dimethoxy-3- (perfluoroethyl) -1H-pyrazolo [3, 4-d] pyrimidine (Scheme 13) Step 1. 1- (4-Chloro-2, 6-dimethoxypyrimidin-5-yl) -2, 2, 3, 3, 3-pentafluoropropan-1-oneTo a stirred solution of 4-chloro-2, 6-dimethoxypyrimidine (0.50 g, 2.86 mmol) in THF (30 mL) at -30under N2was added 2, 2, 6, 6-tetramethylpiperidinylmagnesium chloride lithium chloride complex (1.5 M in THF, 1.4 mL, 2.86 mmol) dropwise. The reaction solution was stirred at -30for 2 h whereupon a copper (I) cyanide di (lithium chloride) complex solution (1 M in THF, 2.86 mL, 2.86 mmol) was added dropwise. The reaction mixture was stirred for an additional 30 min at -30whereupon 2, 2, 3, 3, 3-pentafluoropropanoic anhydride (1.78 g, 5.7 mmol) was added. The reaction mixture allowed to gradually warm to RT and was stirred for 16 h. The resulting mixture was quenched with sat. aq. sodium bicarbonate (50 mL) , diluted with water (50 mL) and extracted with EtOAc (3 x 50 mL) . The combined organic layers were washed with brine (1 x 30 mL) , dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (0-10ethyl acetate in hexanes) to afford the title compound as an oil.1H NMR (400 MHz, CDCl3) delta: 4.11 (s, 3H) , 4.10 (s, 3H) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6320-15-6, 4-Chloro-2,6-dimethoxypyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO. LTD.; SHEN, Dong-Ming; DWYER, Michael; SINZ, Christopher J.; WANG, Deping; STACHEL, Shawn; PAONE, Daniel; NOMLAND, Ashley; BERGER, Richard; CHEN, Yili; QIAN, Yimin; XU, Shimin; HU, Chunmei; (212 pag.)WO2016/192083; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 6320-15-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine, molecular formula is C6H7ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: alpha,beta-unsaturated tosylhydrazones 1 (0.11 mmol, 1.1 equiv), heteroaryl chlorides 2 (0.1 mmol, 1 equiv), Cs2CO3 (0.25 mmol, 2.5 equiv) and MeCN (1 mL) were added to a tube. The mixture was stirred at 60 C until the heteroaryl chlorides was completely disappeared for 4-8h. After cooling to room temperature, the mixture was quenched with NH4Cl (2 mL, saturated aqueous solution) and extracted with CH2Cl2 (3 × 2 mL). The combined organic phases were dried over Na2SO4 and solvents removed in vacuo. The residue was purified by flash column chromatography on silica gel with ethyl acetate/petroleum ether (1:10-1:4, V/V) as the eluent, affording the desired product 3 and 4.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6320-15-6, 4-Chloro-2,6-dimethoxypyrimidine.

Reference:
Article; Zeng, Lin; Guo, Xiao-Qiang; Yang, Zai-Jun; Gan, Ya; Chen, Lian-Mei; Kang, Tai-Ran; Tetrahedron Letters; vol. 60; 33; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine, molecular formula is C6H7ClN2O2, molecular weight is 174.585, as common compound, the synthetic route is as follows.Recommanded Product: 6320-15-6

[00166] lambdaf-[2-({(3JR)-l-[l-(2,6-dimethoxypyrimidin-4-yl)azepan-4-yl]pyrrolidin-3-yl}amino)-2- oxoethyl]-3-(trifluoromethyl)benzamide (20); [00167] To a solution of N-(2-{[(3R)-l-azepan-4-ylpyrrolidin-3-yl]amino}-2-oxoethyl) (trifluoromethyl)benzamide (75 mg, 0.18 mmol) in DMF (1 mL), was added 4-chloro-2,6- dimethoxypyrimidine (32 mg, 0.18 mmol) and diisopropylethylamine (35 muL, 0.20 mmol). The reaction was stirred overnight at 900C, then was cooled to room temperature. To the mixture was added NaHCO3 (sat. aq., 10 mL) and dichloromethane (10 mL). The organic layer was separated and the aqueous layer was washed with an addition portion of dichloromethane (10 mL). The organic layers were combined, dried over Na2SO4, filtered and concentrated. The resulting crude product was subjected to flash chromatography (15% MeOH, 1% NH4OH in EtOAc) to afford, as an approximately 1:1 mixture of diastereomers, benzyl 4-{ (3R)-3-[({ [3-(trifluoromethyl)benzoyl]amino }acetyl)arnino]pyrrolidin-l- yl}azepane-l-carboxylate (50 mg, 50%) as a white solid. 1H-NMR (CDCl3) delta: 1.43-2.05 (m, 7H), 2.20-2.37 (m, IH), 2.39-2.52 (m, 2H), 2.60-2.80 (m, 2H), 2.82-3.10 (m, IH), 3.42-3.80 (m, 4H), 3.87 (s, 3H),3.88 (s, 3H), 4.00-4.18 (m, 2H), 4.40-4.43 (br, IH), 6.67-6.75 (m, IH), 7.33 (br, IH), 7.53 (t, 7 = 7.6 Hz,IH), 7.72 (d, 7= 7.6 Hz, IH), 7.99 (d, 7 = 7.6 Hz, IH), 8.10 (s, IH), MS m/z: 551 (M + 1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6320-15-6, 4-Chloro-2,6-dimethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; WO2007/53495; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 6320-15-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

2-[(S)-1-Phenylethylamino]-4-[5-(2,6-dimethoxypyrimidin-4-yl)benzimidazol-1-yl]pyrimidine The title compound was prepared according to the procedure described in EXAMPLE 424, starting from 2-[(S)-1-Phenylethylamino]-4-[5-trimethylstannylbenzimidazol-1-yl]pyrimidine and 4-chloro-2,6-dimethoxypyrimidine. Mass spectrum (ESI) 443.4 (M+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6320-15-6, 4-Chloro-2,6-dimethoxypyrimidine.

Reference:
Patent; Merck & Co., Inc.; US6498165; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine, the common compound, a new synthetic route is introduced below. category: pyrimidines

Example 83Synthesis of 3-[6-{4-[2,6-dimethoxypyrimidin-4-yl]piperazin-l-yl}-5- phenyl-2-(trifluoromethyl)pyrimidin-4-yl]benzenesulfonamide.Step 1:Preparation of 2,4-dimethoxy-6-piperazin-l-ylpyrimidine.Piperazine (1.23g, 14.32mmol) was treated with 6-chloro-2,4- dimethoxy pyrimidine (0.5g, 2.86mmol) in acetonitrile (5mL) and stirred at room temperature for 6 hours. Subsequently the reaction mixture was poured onto ice-cold water (25mL) and extracted with ethyl acetate (25mL). The organic layer was washed with aqueous sodium bicarbonate solution and evaporated to furnish the required compound.

The synthetic route of 6320-15-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ORCHID RESEARCH LABORATORIES LIMITED; WO2007/83182; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 6320-15-6

piperazine (1.23 g, 14.32 mmol) was treated with 6-chloro-2,4-dimethoxy pyrimidine (0.5 g, 2.86 mmol) in acetonitrile (5 mL) and stirred at room temperature for 6 hours. Subsequently the reaction mixture was poured onto ice-cold water (25 mL) and extracted with ethyl acetate (25 mL). The organic layer was washed with aqueous sodium bicarbonate solution and evaporated to furnish the required compound.

The synthetic route of 6320-15-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ORCHID RESEARCH LABORATORIES LIMITED.; US2007/167413; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia