Category: 6328-58-1

Synthetic Route of 6328-58-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6328-58-1, name is 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one, molecular formula is C6H8N2OS, molecular weight is 156.21, as common compound, the synthetic route is as follows.

[00588] To solution of 6-methyl-2-(methylsulfanyl)-3,4-dihydropyrimidin-4-one Intermediate 1 Step 1 (EV-AO5743-001, 7 g, 44.8 mmol) in water (50ml) and dioxane (100ml) was added NaOH (2.15 g, 53.8 mmol) followed by l-(chloromethyl)-4- methoxybenzene (8.42 g, 53.8 mmol) and stirred at 50 C for 1 h. The reaction mixture was cooled to r.t. and the resultant precipitate filtered under vacuum and purified by chromatography on Si02, eluting with Heptane/EtOAc (gradient 100:0 – 0: 100) to afford the title compound (1.54 g, 11.4%) as an oil. [00589] Method A: LC-MS: m z = +277.0 (M+H)+; RT = 1.40 min.

The chemical industry reduces the impact on the environment during synthesis 6328-58-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; QUARTET MEDICINE, INC.; ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL); TEBBE, Mark, Joseph; ATTON, Holly, Victoria; AVERY, Craig; BROMIDGE, Steven, Mark; KERRY, Mark; KOTEY, Adrian, Kotei; MONCK, Nathaniel, J.; MENICONI, Mirco; RIDGILL, Mark, Peter; TYE, Heather; SAIAH, Eddine; JOHNSSON, Kai, Peter; GORSKA, Katarzyna, Irena; PENG, Hairuo; MCCALL, John, Michael; (356 pag.)WO2017/59191; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6328-58-1, 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6328-58-1, blongs to pyrimidines compound. Recommanded Product: 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one

A mixture of 0.01 mol of 6-methyl-2-(methylsulfanyl)-pyrimidin-4(3H)-one and 0.02 mol of pyrrolidine in 20 mL of butan-1-ol was heated for 15 h at 130140C. The solvent was distilled off, the residue was treated with diethyl ether, and the precipitate was ltered off and dried. Yield 72%, mp 240242C. IR spectrum: nu 1646 cm -1 (C=O). 1 H NMR spectrum, delta, ppm: 1.921.99 m (4H, CH 2 CH 2 ), 2.04 s (3H, CH 3 ), 3.433.51 m (4H, CH 2 NCH 2 ), 5.32 s (1H, 5-H), 10.84 br.s (1H, OH). 13 C NMR spectrum, delta C , ppm: 23.7, 24.7, 46.1, 98.8, 152.2, 163.7, 165.1. Found, %: C 60.21; H 7.26; N 23.20. C 9 H 13 N 3 O. Calculated, %: C 60.32; H 7.31; N 23.45.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6328-58-1, its application will become more common.

Reference:
Article; Pivazyan; Ghazaryan; Azaryan, Zh. A.; Yengoyan; Russian Journal of General Chemistry; vol. 89; 10; (2019); p. 2010 – 2017; Zh. Obshch. Khim.; vol. 89; 10; (2019); p. 1511 – 1519,9;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6328-58-1, name is 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one. This compound has unique chemical properties. The synthetic route is as follows. name: 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one

A mixture of the pyrimidone (324b; 437g), iodine (852.6g) and sodium hydroxide (134.2g) in water (2L) was heated to 80C for 15h. After cooling the reaction was neutralized with acetic acid and the solid collected to give the iodide (324c; 656g) as a light-brown solid. Used in the next step without purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6328-58-1, 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one.

Reference:
Patent; SCHERING CORPORATION; SOUTHERN RESEARCH INSTITUTE; ARASAPPAN, Ashok; NJOROGE, F., George; BENNETT, Frank; GIRIJAVALLABHAN, Vinay, M.; HUANG, Yuhua; HUELGAS, Regina; PIWINSKI, John, J.; SHIH, Neng-Yang; VERMA, Vishal; VELAZQUEZ, Francisco; VENKATRAMAN, Srikanth; KWONG, Cecil, D.; ANANTHAN, Subramaniam; CLARK, Jeremy; GENG, Feng; KEZAR, Hollis, S., III.; MADDRY, Joseph, A.; REYNOLDS, Robert, C.; ROYCHOWDHURY, Abhijit; SECRIST, John, A., III.; FOWLER, Anita, T.; WO2010/22121; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6328-58-1, 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one, blongs to pyrimidines compound. Safety of 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one

b 4-[[(6-Methyl-4(3H)-oxopyrimidin-2-yl)amino]methyl]-benzonitrile Prepared analogously to Example 84b) from 6-methyl-2-(methylthio)pyrimidin-4(3H)-one and 4-cyanobenzenemethanamine in a yield of 67% of theory. Crystals, Mp. 222-224 C. (Methanol). IR (KBr): 3359.8 (N–H), 2227.7 (C N), 1664.5 (C=O) cm-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6328-58-1, 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one, and friends who are interested can also refer to it.

Reference:
Patent; Karl Thomae GmbH; US6114390; (2000); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 6328-58-1, Adding some certain compound to certain chemical reactions, such as: 6328-58-1, name is 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one,molecular formula is C6H8N2OS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6328-58-1.

Propargyl bromide (2) (1.2 mmol, 0.10 mL) was added slowlyto a stirred mixture of 6-methyl-2-(methylthio)pyrimidine-4(3H)-one (1) (1.0 mmol, 0.15 g) and K2CO3 (2.0 mmol,0.27 g) in dry DMF (4 mL) at room temperature, and the mixturewas stirred at room temperature for 10 h. Upon completionof the reaction, the solvent was evaporated under vacuum,and the resulting residue was washed with water. The residuewas finally purified by flash column chromatography (hexane/ethyl acetate = 10:1) to give the titles compounds. Compound (3): TLC (hexane/ethyl acetate = 10:1)Rf = 0.7; yield 70%; white powder; m.p. 80-82 C; 1H NMR(300 MHz, CDCl3): delta 2.38 (s, 3H, CH3), 2.51 (t, J = 2.4 Hz,1H, CH), 2.56 (s, 3H, CH3), 5.00 (d, J = 2.4 Hz, 2H, CH2),6.30 (s, 1H, ArH); 13C NMR (75 MHz, CDCl3): delta 14.0,23.8, 53.6, 74.9, 78.1, 102.0, 167.9, 168.1, 171.3; IR (KBr):3167, 2925, 2116, 1581, 1404, 1339, 1041 cm-1. Anal.calcd for C9H10N2OS: C, 55.65; H, 5.19; N, 14.42; found:C, 55.82; H, 5.28; N, 14.58%.Compound (4): TLC (hexane/ethyl acetate = 10:1) Rf = 0.52;yield 30%; white powder; m.p. 122-124 C; 1H NMR(300 MHz, CDCl3): delta 2.15 (s, 3H, CH3), 2.20 (t, J = 2.4 Hz, 1H,CH), 2.53 (s, 3H, CH3), 4.76 (d, J = 2.4 Hz, 2H, CH2), 6.00(s, 1H, ArH); 13C NMR (75 MHz, CDCl3): delta 15.1, 23.8, 32.6,72.3, 107.6, 161.1, 161.3, 162.7; IR (KBr): 3124, 3001, 1645,1581, 1543, 1461 cm-1. Anal. calcd for C9H10N2OS: C, 55.65;H, 5.19; N, 14.42; found: C, 55.79; H, 5.11; N, 14.28%.

According to the analysis of related databases, 6328-58-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Rezaeimanesh, Fatemeh; Bakherad, Mohammad; Nasr-Isfahani, Hossein; Journal of Chemical Research; vol. 43; 9-10; (2019); p. 431 – 436;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6328-58-1, 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H8N2OS, blongs to pyrimidines compound. Computed Properties of C6H8N2OS

To the round bottom flask containing 6-methyl-2-(methylthio)pyrimidin-4(3H)-one (19 g, 121.6 mmol) was added POCl3 (30 mL). The reaction mixture was heated to reflux for 2 h and then concentrated on a rotary evaporator to dryness. The crude 4-chloro-6-methyl-2- (methylthio)pyrimidine was used directly in the next reaction without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6328-58-1, 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one, and friends who are interested can also refer to it.

Reference:
Patent; EXELIXIS, INC.; WO2008/124161; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia