Category: 633328-98-0

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 633328-98-0, name is 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine, molecular formula is C5H3ClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine

NaH in mineral oil (570 mg, 14 mmol) was slowly added at 0 C. to a solution of 5-chloro-1H-pyrazolo[4,3-d]pyrimidine (2.0 g, 13 mmol) and [beta-(trimethylsilyl)ethoxy]methyl chloride (2.40 mL, 13.6 mmol) in tetrahydrofuran (25 mL). After stirring at r.t. for 1 h, the reaction mixture was quenched by the addition of water and the resulting mixture was extracted with ethyl acetate. The organic phase was washed with brine and dried over sodium sulfate. The solvents were evaporated under reduced pressure and the crude product was purified by Biotage Isolera (2.36 g, 64%). LCMS calculated for C11H18ClN4OSi (M+H)+ m/z=285.1; found 285.2

With the rapid development of chemical substances, we look forward to future research findings about 633328-98-0.

Reference:
Patent; Incyte Corporation; Vechorkin, Oleg; Liu, Kai; Pan, Jun; Sokolsky, Alexander; Ye, Hai Fen; Ye, Qinda; Yao, Wenqing; Hummel, Joshua; (117 pag.)US2018/72741; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 633328-98-0, 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine, blongs to pyrimidines compound. Recommanded Product: 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine

In a 50 mL round-bottom flask with a stir bar, 5-chloro-1H-pyrazolo[4,3-d]pyrimidine (Oxchem, 600 mg, 3.88 mmol) and triethylamine (649 mul, 4.66 mmol) were dissolved in CH2Cl2 (12.9 mL). Di-tert-butyl dicarbonate (991 mul, 4.27 mmol) was added, and the reaction mixture was stirred at r.t. for 1 h. The reaction mixture was then diluted with water, extracted with CH2Cl2, and the combined organic layers were dried over magnesium sulfate and concentrated under reduced pressure. The crude product was purified by Biotage Isolera (860 mg, 87%). LCMS calculated for C10H12ClN4O2 (M+H)+ m/z=255.1; found 255.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,633328-98-0, 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Incyte Corporation; Vechorkin, Oleg; Liu, Kai; Pan, Jun; Sokolsky, Alexander; Ye, Hai Fen; Ye, Qinda; Yao, Wenqing; Hummel, Joshua; (117 pag.)US2018/72741; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 633328-98-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.633328-98-0, name is 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine, molecular formula is C5H3ClN4, molecular weight is 154.5571, as common compound, the synthetic route is as follows.

Step 1A mixture of of 5 -chioro- 1 H-pyrazolo [4,3 -d]pyrimidine (1 g, 6.47 mmol) and NIS (1.747 g, 7.76 mmol) in acetonitrile (6 mL) in a microwave sealed tube was heated to 120C for 40 mm in an oil bath. Then the reaction was cooled down and concentrated to dryness. The residue was purified via gradient C18 chromatography [ISCO, 0 – 100 % water(0.1% TFA) in acetonitrile(0,1% TFA)] which furnished Intermediate Hi.

Statistics shows that 633328-98-0 is playing an increasingly important role. we look forward to future research findings about 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DEMONG, Duane; GRESHOCK, Thomas, J.; CHANG, Ronald, K.; DAI, Xing; LIU, Hong; MCCAULEY, John, A.; LI, Wei; BASU, Kallol; SCOTT, Jack, D.; MILLER, Michael; WO2015/26683; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia