Category: 640769-70-6

Wang, Xiao-Jun; Xu, Yibo; Zhang, Li; Krishnamurthy, Dhileepkumar; Senanayake, Chris H. published an article in Organic Letters. The title of the article was 《Mild Iodine-Magnesium Exchange of Iodoaromatics Bearing a Pyrimidine Ring with Isopropylmagnesium Chloride》.Reference of 3-(Pyrimidin-5-yl)benzaldehyde The author mentioned the following in the article:

(Iodo)arenes bearing a reactive pyrimidine ring underwent a clean iodine-magnesium exchange with isopropylmagnesium chloride in the presence of bis[2-(dimethylamino)ethyl] ether to provide the corresponding Grignard reagents. The presence of bis[2-(dimethylamino)ethyl] ether prevented reduction of the pyrimidine ring and addition by isopropylmagnesium chloride. As a result, the newly formed reactive Grignard reagents were allowed to react with electrophiles in a highly selective manner to afford adducts in excellent yields. In the experimental materials used by the author, we found 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Reference of 3-(Pyrimidin-5-yl)benzaldehyde)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Reference of 3-(Pyrimidin-5-yl)benzaldehydeThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Viswanathan, Kishore; Frey, Kathleen M.; Scocchera, Eric W.; Martin, Brooke D.; Swain, P. Whitney III; Alverson, Jeremy B.; Priestley, Nigel D.; Anderson, Amy C.; Wright, Dennis L. published their research in PLoS One on February 29 ,2012. The article was titled 《Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes》.Category: pyrimidines The article contains the following contents:

Hospital- and community-acquired, complicated skin and soft tissue infections, often attributed to Staphylococcus aureus and Streptococcus pyogenes, present a significant health burden that is associated with increased health care costs and mortality. As these two species are difficult to discern on diagnosis and are associated with differential profiles of drug resistance, the development of an efficacious antibacterial agent that targets both organisms is a high priority. Herein we describe a structure-based drug development effort that has produced highly potent inhibitors of dihydrofolate reductase from both species. Optimized propargyl-linked antifolates containing a key pyridyl substituent display antibacterial activity against both methicillin-resistant S. aureus and S. pyogenes at MIC values below 0.1 μg/mL and minimal cytotoxicity against mammalian cells. Further evaluation against a panel of clin. isolates shows good efficacy against a range of important phenotypes such as hospital- and community-acquired strains as well as strains resistant to vancomycin. In the experiment, the researchers used 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Category: pyrimidines)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Category: pyrimidinesThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Senthamarai, Thirusangumurugan; Chandrashekhar, Vishwas G.; Rockstroh, Nils; Rabeah, Jabor; Bartling, Stephan; Jagadeesh, Rajenahally V.; Beller, Matthias published an article on February 10 ,2022. The article was titled 《A “”universal”” catalyst for aerobic oxidations to synthesize (hetero)aromatic aldehydes, ketones, esters, acids, nitriles, and amides》, and you may find the article in Chem.Reference of 3-(Pyrimidin-5-yl)benzaldehyde The information in the text is summarized as follows:

Here, the preparation of graphitic layers encapsulated in Co-nanoparticles by pyrolysis of cobalt-piperazine-tartaric acid complex on carbon as a most general oxidation catalyst was reported. This unique material allows for the synthesis of simple, functionalized, and structurally diverse (hetero)aromatic aldehydes, ketones, carboxylic acids, esters, nitriles, and amides from alcs. in excellent yields in the presence of air. In the experiment, the researchers used 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Reference of 3-(Pyrimidin-5-yl)benzaldehyde)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Reference of 3-(Pyrimidin-5-yl)benzaldehydeThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Quality Control of 3-(Pyrimidin-5-yl)benzaldehydeOn March 10, 2016, Wu, Yong-Jin; Guernon, Jason; Yang, Fukang; Snyder, Lawrence; Shi, Jianliang; McClure, Andrea; Rajamani, Ramkumar; Park, Hyunsoo; Ng, Alicia; Lewis, Hal; Chang, Chieh Ying; Camac, Dan; Toyn, Jeremy H.; Ahlijanian, Michael K.; Albright, Charles F.; Macor, John E.; Thompson, Lorin A. published an article in ACS Medicinal Chemistry Letters. The article was 《Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents》. The article mentions the following:

By targeting the flap backbone of the BACE1 active site, the authors discovered 6-dimethylisoxazole-substituted biaryl aminothiazine I with 34-fold improved BACE1 inhibitory activity over the lead compound The cocrystal structure of I bound to the active site indicated two hydrogen-bond interactions between the dimethylisoxazole and threonine 72 and glutamine 73 of the flap. Incorporation of the dimethylisoxazole substitution onto the related aminothiazine carboxamide series led to pyrazine-carboxamide II as a very potent BACE1 inhibitor (IC50 < 1 nM). This compound demonstrated robust brain Aβ reduction in rat dose-response studies. Thus, compound II may be useful in testing the amyloid hypothesis of Alzheimer's disease. The experimental process involved the reaction of 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Quality Control of 3-(Pyrimidin-5-yl)benzaldehyde)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Quality Control of 3-(Pyrimidin-5-yl)benzaldehyde

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors》 was published in Beilstein Journal of Organic Chemistry in 2012. These research results belong to Che, Chao; Li, Song; Yang, Bo; Xin, Shengchang; Yu, Zhixiong; Shao, Taofeng; Tao, Chuanye; Lin, Shuo; Yang, Zhen. Application In Synthesis of 3-(Pyrimidin-5-yl)benzaldehyde The article mentions the following:

The previously described 3-chloro-N-[trans-4-(propylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide [Sant-75] (I) is a newly identified potent inhibitor of the Hedgehog pathway [Smo receptor (Smoothened) antagonist]. The authors designed a diversity-oriented synthesis program and the synthesis of the target compounds (series of Sant-75 analogs) was achieved, which lays a foundation for further investigation of the structure-activity relationship of this important class of hedgehog-pathway inhibitors. The results came from multiple reactions, including the reaction of 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Application In Synthesis of 3-(Pyrimidin-5-yl)benzaldehyde)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Application In Synthesis of 3-(Pyrimidin-5-yl)benzaldehyde

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reddy, Bhoomireddy Rajendra Prasad; Reddy, Motakatla Venkata Krishna; Reddy, Peddiahgari Vasu Govardhana; Kumar, Dharani Praveen; Shankar, Muthukonda V. published an article on February 10 ,2016. The article was titled 《Protonated trititanate nanotubes: an efficient catalyst for one-pot three-component coupling of benzothiazole amines, heterocyclic aldehydes, and dialkyl/diaryl phosphites with a greener perspective》, and you may find the article in Tetrahedron Letters.Product Details of 640769-70-6 The information in the text is summarized as follows:

Nano-size catalysts of TiO2, ZnO, CuO, and protonated trititanate nanotubes (H2Ti3O7) have been investigated for the one-pot three component synthesis of novel α-aminophosphonates from benzothiazole amines, heteroaldehydes, and dialkyl/diaryl phosphites via Kabachnik-Fields reaction. This methodol. provides a new and convenient approach to multicomponent reaction and the H2Ti3O7 nanotubes catalyst is recyclable up to seven cycles. The experimental process involved the reaction of 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Product Details of 640769-70-6)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Product Details of 640769-70-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

《Polyionic gels: efficient heterogeneous media for metal scavenging and catalysis》 was written by Thiot, Carine; Schmutz, Marc; Wagner, Alain; Mioskowski, Charles. Category: pyrimidines And the article was included in Angewandte Chemie, International Edition on April 28 ,2006. The article conveys some information:

A highly polar micro-environment, which is suitable for efficient metal scavenging and heterogeneous catalyst preparation, is provided by polyionic gel beads prepared from chloromethylated polystyrene (Merrifield resin) and triethylamine or trioctylamine. Complexation of palladium acetate by resin-bound ammonium salts with or without anion exchange provides effective resin-bound recyclable palladium ionic gel catalysts for Suzuki coupling reactions of aryl and heteroaryl bromides with aryl and heteroaryl boronic acids to give biaryls. The heterogeneous media enable easy product isolation and catalyst recycling. The resin-bound benzyltriethylammonium chloride-supported palladium catalyst forms gel-embedded palladium colloid particles under Suzuki coupling reaction conditions. Phenylacetylene is regioselectively and stereoselectively hydrosilylated with diethoxymethylsilane in the presence of a complex derived from the resin-bound benzyltriethylammonium chloride and Wilkinson’s catalyst to give (E)-PhC:CHSiMe(OEt)2 in 89% yield. In addition to this study using 3-(Pyrimidin-5-yl)benzaldehyde, there are many other studies that have used 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Category: pyrimidines) was used in this study.

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Efficient solvent free synthesis of tertiary α-aminophosphonates using H2Ti3O7 nanotubes as a reusable solid-acid catalyst》 were Rajendra Prasad Reddy, Bhoomireddy; Vasu Govardhana Reddy, Peddiahgari; Reddy, Bijivemula N.. And the article was published in New Journal of Chemistry in 2015. Related Products of 640769-70-6 The author mentioned the following in the article:

In this paper, TiO2 fine particles, TiO2-P25, protonated trititanate (H2Ti3O7) nanorods and nanotubes were used as recyclable solid-acid catalysts for the solvent free synthesis of tertiary α-aminophosphonates through Kabachnik-Fields reaction. Among them, H2Ti3O7 nanotubes showed remarkable catalytic performance and it was due to strong and sufficient Lewis and Bronsted acid sites on a large nanotubular surface. More importantly, for the first time we reported some novel 5,8-dioxa-10-azadispiro[2.0.4.3]undecane bearing tertiary α-aminophosphonates. After reading the article, we found that the author used 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Related Products of 640769-70-6)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Related Products of 640769-70-6They have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Safety of 3-(Pyrimidin-5-yl)benzaldehydeOn October 15, 2013 ,《The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Patel, Bhargav A.; Ashby, Charles R.; Hardej, Diane; Talele, Tanaji T.. The article contains the following contents:

A focused library of rhodanine compounds containing novel substituents at the C5-position was synthesized and tested in vitro against a panel of clin. relevant MRSA strains. The present SAR study was based on our lead compound I (Ar = 3-phenoxyphenyl) (MIC = 1.95 μg/mL), with a focus on identifying optimal C5-arylidene substituents. In order to obtain this objective, we condensed several unique aromatic aldehydes with phenylalanine-derived rhodanine intermediates to obtain C5-substituted target rhodanine compounds for evaluation as anti-MRSA compounds These efforts produced three compounds with significant efficacy: I [Ar = 3-(3,4-dichloro)phenoxyphenyl, 3-biphenyl] and II with MIC values ranging from 0.98 to 1.95 μg/mL against all tested MRSA strains as compared to the reference antibiotics penicillin G (MIC = 15.60-250.0 μg/mL) and ciprofloxacin (MIC = 7.80-62.50 μg/mL) and comparable to that of vancomycin (MIC = 0.48 μg/mL). In addition, several other compounds (MIC = 1.95-3.90 μg/mL) were efficacious against all MRSA strains. The majority of the synthesized compounds had bactericidal activity at concentrations only two to fourfold higher than their MIC. Overall, the results suggest that compounds I [Ar = 3-(3,4-dichloro)phenoxyphenyl, 3-biphenyl] and II may be of potential use in the treatment of MRSA infections. The experimental part of the paper was very detailed, including the reaction process of 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6Safety of 3-(Pyrimidin-5-yl)benzaldehyde)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own. Safety of 3-(Pyrimidin-5-yl)benzaldehydeThey have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The author of 《Repurposing strategies on pyridazinone-based series by pharmacophore- and structure-driven screening》 were Floresta, Giuseppe; Crocetti, Letizia; Giovannoni, Maria Paola; Biagini, Pierfrancesco; Cilibrizzi, Agostino. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. COA of Formula: C11H8N2O The author mentioned the following in the article:

We report here in silico repurposing studies on 52 new pyridazinone-based small-mols. through inverse virtual screening (iVS) methodologies. These analogs were originally designed as formyl peptide receptor (FPR) ligands. As it is sometimes the case in drug discovery programs, subsequent biol. screening demonstrated the inefficacy of the mols. in binding FPRs, failing in the identification of new hits. Through a focussed drug-repurposing approach we have defined a variety of potential targets that are suitable to interact with this library of pyridazinone-based analogs. A two-step approach has been conducted for computational anal. Specifically, the mols. were initially processed through a pharmacophore-based screening. Secondly, the resulting features of binding were investigated by docking studies and following mol. dynamic simulations, in order to univocally confirm “”pyridazinone-based ligand-target protein”” interactions. Our findings propose aspartate aminotransferase as the most favorable repurposed target for this small-mol. series, worth of addnl. medicinal chem. investigations in the field. The results came from multiple reactions, including the reaction of 3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6COA of Formula: C11H8N2O)

3-(Pyrimidin-5-yl)benzaldehyde(cas: 640769-70-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics. COA of Formula: C11H8N2O

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia