Category: 65090-78-0

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Attempted synthesis of polypeptides by condensation of amino acid and peptide esters I》. Authors are Brockmann, Hans; Musso, Hans.The article about the compound:2-Bromo-3-methoxypropanoic acidcas:65090-78-0,SMILESS:O=C(O)C(Br)COC).SDS of cas: 65090-78-0. Through the article, more information about this compound (cas:65090-78-0) is conveyed.

Methods are given for fractionation of the amino acid, peptides, and their Me esters in the cases of glycine (I), alanine (II), and serine (III). After several months at room temperature, either dry or in various solvents, I Me ester gave mainly tetraglycine Me ester (IV) and I anhydride (V), as well as some pentaglycine Me ester and hexaglycine Me ester. In H2O, MeOH, or EtOH the product was mostly V. Condensation of II Me ester, either dry or in MeOH, gave mainly II anhydride. In H2O hydrolysis to II occurred. III Me ester (VI), dry or in various solvents at 20°, gave after several weeks mainly III anhydride (VII), with some III and unchanged VI. Vacuum distillation of VI gave VII, III, MeOH, NH3, H2O, II, and traces of III peptides. VI was kept in vacuo at 20°, warmed 1 h. to 75°, refluxed 10 h., or kept at 20° in pyridine or HOAc. In each case the major product was VII, and III, VI, and some III peptides were present. IV kept at various temperatures, dry or in H2O or MeOH, was either unchanged, hydrolyzed, or converted largely to unidentified products.

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Pyrimidine | C4H4N2 – PubChem,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 65090-78-0, is researched, Molecular C4H7BrO3, about N-Substituted amino acid N’-benzylamides: synthesis, anticonvulsant, and metabolic activities, the main research direction is amino acid benzylamide anticonvulsant seizure.COA of Formula: C4H7BrO3.

Amino acid amides (AAA) were prepared and evaluated in seizure models. The AAA displayed moderate-to-excellent activity in the maximal electroshock seizure (MES) test and were devoid of activity in the s.c. Metrazol-induced (scMet) seizure test. The AAA anticonvulsant activity was neither strongly influenced by the C(2) substituent nor by the degree of terminal amine substitution. An in vitro metabolism study suggested that the structure-activity relationship pattern was due, in part, to metabolic processes that occurred at the N-terminal amine unit.

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Pyrimidine | C4H4N2 – PubChem,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 65090-78-0, is researched, Molecular C4H7BrO3, about A convenient and exclusive methoxybromination of alkenes, the main research direction is methoxybromination alkene; methoxyiodination alkene; alkene methoxybromination methoxyiodination; bromination methoxy alkene; iodination methoxy cyclohexene.Application of 65090-78-0.

Alkenes R1CR2:CR3R4 (e.g., R1 = Ph, p-tolyl, H; R2 = H, Me; R3 = HCO2Me; R4 = CO2Me, H) were methoxybrominated with Br in MeOH in the presence of AgNO3, Pb(NO3)2 or yellow Pb oxide (which one depended on the nature of the alkene). Cyclohexene was methoxyiodinated similarly in the presence of AgNO3. Electrophilic addition of the elements of MeOBr was general. The trans and stereospecific nature was established by studying dehydrobromination of methoxybromoadducts under E2 elimination conditions.

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Pyrimidine | C4H4N2 – PubChem,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Attempted synthesis of polypeptides by condensation of amino acid and peptide esters I》. Authors are Brockmann, Hans; Musso, Hans.The article about the compound:2-Bromo-3-methoxypropanoic acidcas:65090-78-0,SMILESS:O=C(O)C(Br)COC).SDS of cas: 65090-78-0. Through the article, more information about this compound (cas:65090-78-0) is conveyed.

Methods are given for fractionation of the amino acid, peptides, and their Me esters in the cases of glycine (I), alanine (II), and serine (III). After several months at room temperature, either dry or in various solvents, I Me ester gave mainly tetraglycine Me ester (IV) and I anhydride (V), as well as some pentaglycine Me ester and hexaglycine Me ester. In H2O, MeOH, or EtOH the product was mostly V. Condensation of II Me ester, either dry or in MeOH, gave mainly II anhydride. In H2O hydrolysis to II occurred. III Me ester (VI), dry or in various solvents at 20°, gave after several weeks mainly III anhydride (VII), with some III and unchanged VI. Vacuum distillation of VI gave VII, III, MeOH, NH3, H2O, II, and traces of III peptides. VI was kept in vacuo at 20°, warmed 1 h. to 75°, refluxed 10 h., or kept at 20° in pyridine or HOAc. In each case the major product was VII, and III, VI, and some III peptides were present. IV kept at various temperatures, dry or in H2O or MeOH, was either unchanged, hydrolyzed, or converted largely to unidentified products.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Recommanded Product: 2-Bromo-3-methoxypropanoic acid. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Bromo-3-methoxypropanoic acid, is researched, Molecular C4H7BrO3, CAS is 65090-78-0, about A convenient and exclusive methoxybromination of alkenes. Author is Vishwakarma, L. C.; Walia, J. S..

Alkenes R1CR2:CR3R4 (e.g., R1 = Ph, p-tolyl, H; R2 = H, Me; R3 = HCO2Me; R4 = CO2Me, H) were methoxybrominated with Br in MeOH in the presence of AgNO3, Pb(NO3)2 or yellow Pb oxide (which one depended on the nature of the alkene). Cyclohexene was methoxyiodinated similarly in the presence of AgNO3. Electrophilic addition of the elements of MeOBr was general. The trans and stereospecific nature was established by studying dehydrobromination of methoxybromoadducts under E2 elimination conditions.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Bromo-3-methoxypropanoic acid, is researched, Molecular C4H7BrO3, CAS is 65090-78-0, about Study on by-products in N-benzyl-2-bromo-3-methoxypropionamide by mixed anhydride methods, the main research direction is byproduct benzyl bromo methoxypropionamide mixed anhydride.Recommanded Product: 2-Bromo-3-methoxypropanoic acid.

N-Benzyl-2-bromo-3-methoxypropionamide was synthesized from 2-bromo-3-methoxypropionic acid by mixed anhydride methods. The main impurities were separated and analyzed. Furthermore, the mechanism of the production of the main impurities was discussed. The mol. structures of impurities were confirmed by 1 H NMR, 13C NMR, IR.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Nippon Kagaku Kaishi (1921-47) called Synthesis of hydroxyamino acids and N-methyl derivatives. III. Synthesis of DL-serine and N-methylserine, Author is Izumiya, Nobuo, which mentions a compound: 65090-78-0, SMILESS is O=C(O)C(Br)COC, Molecular C4H7BrO3, Name: 2-Bromo-3-methoxypropanoic acid.

cf. C.A. 45, 4656e. Exptl. procedures for the synthesis of DL-serine and N-methylserine from CH2:CHCO2H (I) are described. I (14.4 g.) added to 14 g. Hg(OAc)2 in 300 cc. of MeOH, and gave after 2 days 54 g. α-acetoxymercuri-β-methoxypropionic acid, m. 200-4°; to this in 200 cc. water and 36 g. KBr, in direct sunlight, was added dropwise 32 g. Br and 36 g. KBr in 60 cc. water; extraction of the mixture with ether after addition of 33 cc. 48% HBr gave 37 g. crude α-bromo-β-methoxypropionic acid (II), b4 92-5°. Aqueous NH3 with 37 g. II gave the α-amino acid (III), decompose 233-4°, in 34% yield (based on I); Cu salt, C8H16O6N2Cu, scarcely soluble in water; phenylurea, MeOCH2CH(NHCONHPh)CO2H, m. 171-2°; N-(p-tolylsulfonyl) derivative (IV), m. 139-41°. Serine was obtained by boiling crude III with 48% HBr (yield 41%, based on I). Heating IV with MeI and 2 N NaOH 1 hr. in a sealed tube at 70° gave β-methoxy-α-[methyl(p-tolylsulfonyl)amino]propionic acid (V), C12H17O5NS, m. 92°. Heating crude 3.7 g. II and 35% 9 cc. MeNH2 4 hrs. in a sealed tube at 100° gave 0.74 g. β-methoxy- α-(methylamino)propionic acid (VI), m. 233° (decomposition); picrolonate, C15H19O8N5, m. 120-1° (decomposition); Cu salt, C10H20O6N2Cu.3H2O, m. 234° (decomposition). The crude product from II and MeNH2 gave with 48% HBr N-methylserine, m. 203-4° (decomposition), 30% yield (based on I); picrolonate, C14H17O8N5, m. 130-4° (decomposition); Cu salt, C8H16O6N2Cu, m. 197-8° (decomposition). VI was also obtained by hydrolysis of V with concentrated HCl.

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Pyrimidine | C4H4N2 – PubChem,
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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Bromo-3-methoxypropanoic acid, is researched, Molecular C4H7BrO3, CAS is 65090-78-0, about Tailored Synthesis of Skeletally Diverse Stemona Alkaloids through Chemoselective Dyotropic Rearrangements of β-Lactones, the main research direction is stemona alkaloid synthesis chemoselective dyotropic rearrangement lactone; alkaloids; dyotropic rearrangement; natural products; photoredox catalysis; total synthesis.Quality Control of 2-Bromo-3-methoxypropanoic acid.

The collective synthesis of skeletally diverse Stemona alkaloids featuring tailored dyotropic rearrangements of β-lactones as key elements is described. Specifically, three typical 5/7/5 tricyclic skeletons associated with stemoamide, tuberostemospiroline and parvistemonine were first accessed through chemoselective dyotropic rearrangements of β-lactones involving alkyl, hydrogen, and aryl migration, resp. By the rational manipulation of substrate structures and reaction conditions, these dyotropic rearrangements proceeded with excellent efficiency, good chemoselectivity and high stereospecificity. Furthermore, several polycyclic Stemona alkaloids, including saxorumamide, isosaxorumamide, stemonine and bisdehydroneostemoninine (I – IV, resp.), were obtained from the aforementioned tricyclic skeletons through late-stage derivatizations. A novel visible-light photoredox-catalyzed formal [3+2] cycloaddition was also developed, which offers a valuable tool for accessing oxaspirobutenolide and related scaffolds.

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Pyrimidine | C4H4N2 – PubChem,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《dl-Serine》. Authors are Carter, Herbert E.; West, Harold D..The article about the compound:2-Bromo-3-methoxypropanoic acidcas:65090-78-0,SMILESS:O=C(O)C(Br)COC).SDS of cas: 65090-78-0. Through the article, more information about this compound (cas:65090-78-0) is conveyed.

Me acrylate (450 g. of a 60% solution in MeOH) is treated with 180 g. MeOH and 960 g. Hg(OAc)2 and allowed to stand 3 days at room temperature; it is cooled in an ice bath and treated with 360 g. KBr in 1200 cc. H2O; the CHCl3 extract is warmed to 50° and treated in direct sunlight with 450 g. Br, giving a crude yield of 480-510 g. of Me α-bromo-β-methoxypropionate; this is transformed into the free acid with 5 N NaOH which is heated with concentrated NH4OH at 90-100° for 10-15 hrs. This gives 30-40% of dl-serine based on the Hg(OAc)2 used. The solubility of dl-serine in H2O is 50 g. per 1. at 25°, 200 g. at 80° and approx. 30 g. at 5-10°.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Attempted synthesis of polypeptides by condensation of amino acid and peptide esters I, published in 1954, which mentions a compound: 65090-78-0, mainly applied to , Name: 2-Bromo-3-methoxypropanoic acid.

Methods are given for fractionation of the amino acid, peptides, and their Me esters in the cases of glycine (I), alanine (II), and serine (III). After several months at room temperature, either dry or in various solvents, I Me ester gave mainly tetraglycine Me ester (IV) and I anhydride (V), as well as some pentaglycine Me ester and hexaglycine Me ester. In H2O, MeOH, or EtOH the product was mostly V. Condensation of II Me ester, either dry or in MeOH, gave mainly II anhydride. In H2O hydrolysis to II occurred. III Me ester (VI), dry or in various solvents at 20°, gave after several weeks mainly III anhydride (VII), with some III and unchanged VI. Vacuum distillation of VI gave VII, III, MeOH, NH3, H2O, II, and traces of III peptides. VI was kept in vacuo at 20°, warmed 1 h. to 75°, refluxed 10 h., or kept at 20° in pyridine or HOAc. In each case the major product was VII, and III, VI, and some III peptides were present. IV kept at various temperatures, dry or in H2O or MeOH, was either unchanged, hydrolyzed, or converted largely to unidentified products.

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Pyrimidine | C4H4N2 – PubChem,
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