Category: 6554-61-6

Gershon, Herman; Parmegiani, Raulo published the artcile< Antifungal activity of ring poly-chlorinated pyrimidines: structure activity relations>, Formula: C4H2Cl2N2, the main research area is DRUG RESISTANCE, MICROBIAL; FUNGICIDES; PYRIMIDINES.

A total of 48 ring chlorinated pyrimidines were screened against strains of 5 fungi by the disk-plate method, liquid culture, and for activity of the vapors of the compounds Correlations of the results obtained by the 3 methods were made, and structure:activity relations were discussed. The outstanding members of this series were found to be 2,4,5-trichloropyrimidine, 4,5,6-trichloropyrimidine, and 2-chloro-methyl-4,5,6-trichloropyrimidine.

Applied Microbiology published new progress about 6554-61-6. 6554-61-6 belongs to class pyrimidines, and the molecular formula is C4H2Cl2N2, Formula: C4H2Cl2N2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

von Angerer, S. published the artcile< Product class 12: pyrimidines>, HPLC of Formula: 6554-61-6, the main research area is review pyrimidine preparation cyclization ring transformation aromatization.

A review. Methods for preparing pyrimidines are reviewed including cyclization, ring transformation, aromatization and substituent modification.

Science of Synthesis published new progress about Aromatization. 6554-61-6 belongs to class pyrimidines, and the molecular formula is C4H2Cl2N2, HPLC of Formula: 6554-61-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Krasavin, Mikhail; Mujumdar, Prashant; Parchinsky, Vladislav; Vinogradova, Tatiana; Manicheva, Olga; Dogonadze, Marine published the artcile< Library of diversely substituted 2-(quinolin-4-yl)imidazolines delivers novel non-cytotoxic antitubercular leads>, COA of Formula: C4H2Cl2N2, the main research area is quinolinylimidazoline derivative preparation antitubercular antimalarial; 2-imidazoline; Antimalarial; Buchwald–Hartwig; antitubercular; microwave chemistry; non-cytotoxic; quinoline.

A novel library based on quinolin-4-ylimidazoline core was designed to incorporate a general quinoline antimicrobial pharmacophore. A synthesis of the well-characterized library of 36 compounds was achieved using the Pd-catalyzed Buchwald-Hartwig-type imidazoline arylation chem. developed earlier. Compounds were tested for biol. activity and were found to possess no antimalarial activity. However, the library delivered two promising antitubercular leads, which are non-cytotoxic and can be further optimized with respect to antimycobacterial potency.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Antimalarials. 6554-61-6 belongs to class pyrimidines, and the molecular formula is C4H2Cl2N2, COA of Formula: C4H2Cl2N2.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ognyanov, Vassil I.; Balan, Chenera; Bannon, Anthony W.; Bo, Yunxin; Dominguez, Celia; Fotsch, Christopher; Gore, Vijay K.; Klionsky, Lana; Ma, Vu V.; Qian, Yi-Xin; Tamir, Rami; Wang, Xianghong; Xi, Ning; Xu, Shimin; Zhu, Dawn; Gavva, Narender R.; Treanor, James J. S.; Norman, Mark H. published the artcile< Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles>, Category: pyrimidines, the main research area is benzimidazole piperazinyl preparation transient receptor potential vanilloid antagonist antihyperalgesic.

The vanilloid receptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expressed by peripheral neurons sensing painful stimuli. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. The synthesis and the structure-activity relationships of a series of 2-(4-pyridin-2-ylpiperazin-1-yl)-1H-benzo[d]imidazoles I [R1 = H, Me3SiCH2CH2OCH2, PhCH2; R2 = F, Cl, Br, F3C, Me, CN, Me3C, MeO2C, etc.; R3 = H, 4-(2-thiazolyl), 4-(4-pyridyl), 5-(4-F3CC6H4), etc.; R4 = H, Me; R5 = H, H2N, MeCHOH, H2C:CH, etc.; R6 = H, Cl, F3C, etc.] and analogs as novel TRPV1 antagonists have been described. I [R1 = H; R2 = F3C; R3 = 4-(3,4,5-F3C6H2); R4 = (R)-Me; R5 = HOCH2CHOH; R6 = Cl; (II)] was among the most potent analogs in this series. This compound was orally bioavailable in rats and was efficacious in blocking capsaicin-induced flinch in rats in a dose-dependent manner. II also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund’s adjuvant (CFA).

Journal of Medicinal Chemistry published new progress about Analgesics. 6554-61-6 belongs to class pyrimidines, and the molecular formula is C4H2Cl2N2, Category: pyrimidines.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ribeiro da Silva, Manuel A. V.; Amaral, Luisa M. P. F.; Gomes, Jose R. B. published the artcile< Comparative Computational and Experimental Study on the Thermochemistry of the Chloropyrimidines>, Related Products of 6554-61-6, the main research area is comparative computation experiment thermochem chloropyrimidine; enthalpy formation vaporization sublimation chloropyrimidine calorimetry computation.

The standard (p0 = 0.1 MPa) molar enthalpies of formation, ΔfHM0, for liquid 2,4,6-trichloropyrimidine and for crystalline 2-chloropyrimidine, 2,4- and 4,6-dichloropyrimidine, and 2,4,5,6-tetrachloropyrimidine compounds were determined at T = 298.15 K by rotating-bomb combustion calorimetry. The standard molar enthalpies of vaporization or sublimation of these compounds at T = 298.15 K were determined by Calvet microcalorimetry. The exptl. standard molar enthalpies of formation of those compounds, in the gaseous state, at T = 298.15 K, were thus obtained by combining these two sets of results. The latter values have been employed in the calibration of the computational procedure, which has been used to estimate the gas-phase enthalpies of formation for the other chloropyrimidines that were not possible to obtain in a pure form for the exptl. study. The exchange-correlation functional based on the local spin d. approximation (LSDA) seems to be a cheap choice for the estimation of enthalpies of formation for heterocycles containing nitrogen atoms; the well-known B3LYP hybrid method yields larger differences, with respect to the exptl. values, for 2,4,6-tri- and 2,4,5,6-tetrachloropyrimidines.

Journal of Physical Chemistry B published new progress about Combustion enthalpy. 6554-61-6 belongs to class pyrimidines, and the molecular formula is C4H2Cl2N2, Related Products of 6554-61-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6554-61-6, 4,5-Dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4,5-Dichloropyrimidine, blongs to pyrimidines compound. Safety of 4,5-Dichloropyrimidine

A solution of 4,5-dichloropyrimidine (0.15 mL, 1.5 mmol) and 2-((pyridin-2-ylmethyl)thio)-1 /-/- benzo[d]imidazole R (300 mg, 1.24 mmol) in dry DMF (1.5 mL) was treated with a 60% mineral oil dispersion of sodium hydride (55 mg, 1.4 mmol), stirred at RT for 5 min then heated to 70C for 90 min. The mixture was treated with saturated aqueous ammonium chloride solution (2 mL), diluted with EtOAc (40 mL), washed with water (3 x 40 mL) and brine, dried (MgSCU) and chromatographed on a basic silica column eluting with 0-100% EtOAc / PE. The product was purified further by mass-directed prep. HPLC eluting with MeCN-H20 to give 1-(5-chloropyrimidin-4-yl)-2-((pyridin-2-ylmethyl)thio)-1 /-/- benzo[d]imidazole 59 (22 mg, 5%) as a pale orange gum. 1H NMR (500 MHz, CDC) delta 9.15 (s, 1H), 8.96 (s, 1H), 8.52 (d, J = 4.3 Hz, 1H), 7.76 (d, J = 8.0 Hz, 1H), 7.60 (td, J = 7.7, 1.8 Hz, 1H), 7.47 (d, J = 7.8 Hz, 1H), 7.36-7.29 (m, 1H), 7.25- 7.20 (m, 1H), 7.16 (dd, J = 6.8, 5.0 Hz, 1H), 7.05 (d, J = 8.0 Hz, 1H), 4.77 (s, 2H); LCMS (method B): 2.23 min (354.2, MH+).

The synthetic route of 6554-61-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REDAG CROP PROTECTION LTD; URCH, Christopher, John; BUTLIN, Roger, John; CHRISTOU, Stephania; BOOTH, Rebecca, Kathryn; (111 pag.)WO2018/130838; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 6554-61-6 , The common heterocyclic compound, 6554-61-6, name is 4,5-Dichloropyrimidine, molecular formula is C4H2Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

1- { 3- [2-methoxy-5 -nitro-4-(tetramethyl- 1,3 ,2-dioxaborolan-2-yl)phenoxy]propyl }pynolidine (500 mg, 1.23 mmol), 4,5-dichloropyrimidine (220 mg, 1.48 mmol), Pd(amphos)C12 (59 mg, 0.08 mmol) and 2M sodium carbonate (1.23 mL, 2.46 mmol) were combined in 1,4-dioxane (5 mL). The mixture was purged with N2 for 6 mm, sealed and left stifling at 90 C for 45 minutes. The mixture was cooled to room temperature, diluted with water and extracted with ethyl acetate. The combinedorganic layers were washed with water. After removal of the organic solvents under reduced pressure, the residue was purified by flash chromatography on silica gel column eluted with 0-100% solvent A in CH2C12 (solvent A: 0.2% NH4OH/10% MeOH/88.9%CH2C12) to provide the title compound as a brown solid (422 mg, 87%). MS (ESI, pos. ion) mlz: 393.0 (M+1).

The synthetic route of 6554-61-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLOBAL BLOOD THERAPEUTICS, INC.; YU, Chul; YU, Ming; ZANCANELLA, Manuel; LI, Zhe; (202 pag.)WO2018/226998; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia