Category: 66373-25-9

Tseng, Chih-Hua published the artcileSynthesis and antiproliferative evaluation of 3-phenylquinolinylchalcone derivatives against non-small cell lung cancers and breast cancers, Category: pyrimidines, the main research area is methoxyphenylquinolinyl aryl propenone stereoselective preparation antitumor activity; structure methoxyphenylquinolinyl aryl propenone inhibition human cancer normal cell; breast non small cell lung cancer inhibition methoxyphenylquinolinyl arylpropenone; cell cycle progression cellular administration methoxyphenylquinolinyl aryl propenone; cleavage apoptotic protein cellular administration methoxyphenylquinolinyl aryl propenone; methoxyphenyl methoxyphenylquinolinyl propenone mol crystal structure.

3-(4-Methoxyphenyl)quinolinyl aryl propenones I [R = Ph, 4-FC6H4, 4-HOC6H4, 4-MeOC6H4, 2,4-(MeO)2C6H3, 2,6-(MeO)2C6H3, 3,4-(MeO)2C6H3, 3,5-(MeO)2C6H3, 4-H2NC6H4, 4-O2NC6H4, 2-furyl, 2-thienyl, 2-pyridinyl, 5-Br-2-thienyl, 3-thienyl, 2-pyrrolyl, 3-amino-2-thienyl, 2-amino-4-methyl-5-pyrimidinyl, 3-indolyl] were prepared as potential antitumor agents. I (R = Ph) inhibited the growth of H1299 non-small cell lung cancer and SKBR-3 breast cancer cells with IC50 values of 1.41 and 0.70 μM, resp., while the standard topotecan inhibited their growth with IC50 values of 6.02 and 8.91 μM, resp. I (R = 5-Br-2-thienyl) inhibited the growth of MDA-MB-231 breast cancer cells with an IC50 value of less than 0.10 μM, while inhibiting the growth of noncancerous mammary epithelial cells at an IC50 value of 9.38 μM. I (R = 5-Br-2-thienyl) induced cell cycle arrest at G2/M phase followed by activation of caspase-3, cleavage of PARP, and cell death. The structure of I [R = 2,4-(MeO)2C6H3] was determined by X-ray crystallog.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 66373-25-9 belongs to class pyrimidines, name is 1-(2-Amino-4-methylpyrimidin-5-yl)ethanone, and the molecular formula is C7H9N3O, Category: pyrimidines.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Miura, Takaaki published the artcileLead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design, Recommanded Product: 1-(2-Amino-4-methylpyrimidin-5-yl)ethanone, the main research area is HSP90 inhibitor virtual screening antitumor structure drug design cancer; anticancer CH5015765 preparation 3D Xray HSP90 complex crystal structure; aminotriazine aminopyrimidine derivative mol structure HSP90 target antitumor design.

Heat shock protein 90 (Hsp90) is a mol. chaperone which regulates maturation and stabilization of its substrate proteins, known as client proteins. Many client proteins of Hsp90 are involved in tumor progression and survival and therefore Hsp90 can be a good target for developing anticancer drugs. With the aim of efficiently identifying a new class of orally available inhibitors of the ATP binding site of this protein, we conducted fragment screening and virtual screening in parallel against Hsp90. This approach quickly identified 2-aminotriazine and 2-aminopyrimidine derivatives as specific ligands to Hsp90 with high ligand efficiency. In silico evaluation of the 3D X-ray Hsp90 complex structures of the identified hits allowed us to promptly design CH5015765, which showed high affinity for Hsp90 and antitumor activity in human cancer xenograft mouse models.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 66373-25-9 belongs to class pyrimidines, name is 1-(2-Amino-4-methylpyrimidin-5-yl)ethanone, and the molecular formula is C7H9N3O, Recommanded Product: 1-(2-Amino-4-methylpyrimidin-5-yl)ethanone.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Mosti, Luisa published the artcileReaction of 2-dimethylaminomethylene-1,3-diones with dinucleophiles. III. Synthesis of 5-acylpyrimidines and 7,8-dihydroquinazolin-5(6H)-ones, Synthetic Route of 66373-25-9, the main research area is methylaminomethylene dione cyclocondensation dinucleophile; pyridine acyl; quinazolinone dihydro.

The reaction of open-chain and cyclohexane sym-2-dimethylaminomethylene-1,3-diones with amidines and guanidine in refluxing ethanol gave, generally in good yields, acylpyrimidines I (R = Me, Me2CH, Me3C, Ph; R1 = H, Me, Ph, NH2) and dihydroquinazolinones II (X = CH2, CMe2, CHPh) resp. With formamidine (and in part acetamidine), 2-formylimino-1,3-diones, e.g., III, were formed as sole products or mixtures with pyrimidines or dihydroquinazolinones.

Journal of Heterocyclic Chemistry published new progress about Cyclocondensation reaction. 66373-25-9 belongs to class pyrimidines, name is 1-(2-Amino-4-methylpyrimidin-5-yl)ethanone, and the molecular formula is C7H9N3O, Synthetic Route of 66373-25-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Arya, V. P. published the artcilePsychoactive agents. Part VI. Synthesis and central nervous system effects of some 2-substituted 5-acetyl-4-methylpyrimidine derivatives, Product Details of C7H9N3O, the main research area is pyrimidine acetyl; central nervous system acetylpyrimidine; bactericide furylvinylpyrimidine.

The synthesis of 2-substituted 5-acetyl-4-methylpyrimidines is described. Thus, amidines and substituted guanidines react with EtOCH:C(COMe)2 to give the 5-acetyl-4-methyl-2-substituted pyrimidines I (R = NH2, MeS, morpholino, Ph, etc.). Aminolysis of I (R = MeS) with cyclic secondary amines gave I (R = piperidino, piperazino, pyrrolidino, etc.). Some of these amines were converted to their guanylhydrazones. Mannich condensation of I (R = morpholino) gave II. Some I had central nervous system and bactericidal activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Cyclocondensation reaction. 66373-25-9 belongs to class pyrimidines, name is 1-(2-Amino-4-methylpyrimidin-5-yl)ethanone, and the molecular formula is C7H9N3O, Product Details of C7H9N3O.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Klumpp, Douglas A. published the artcileElectrophilic activation of acetyl-substituted heteroaromatic compounds, Computed Properties of 66373-25-9, the main research area is electrophilic activation condensation benzene heteroaromatic compound; superacid mediated condensation heteroaromatic methyl ketone benzene.

The chem. of acetyl-substituted pyridines, thiazoles, quinoline, isoquinolines, and pyrazine, e.g., thiazole I, has been studied. These heteroarenes condense with benzene in good yields (74-96%) in the Bronsted superacid, CF3SO3H (triflic acid). Thus, reaction of I gave diphenylthiazole II in 91% yield. In these acid-catalyzed hydroxyalkylation reactions, the heteroarene compounds are significantly more reactive than acetophenone. It is proposed that the heteroarene compounds readily form dicationic electrophiles in triflic acid.

Journal of Organic Chemistry published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 66373-25-9 belongs to class pyrimidines, name is 1-(2-Amino-4-methylpyrimidin-5-yl)ethanone, and the molecular formula is C7H9N3O, Computed Properties of 66373-25-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Ungoren, Sevket Hakan published the artcileDBU-catalyzed, aromatization-oriented, regioselective domino synthesis of 2-aminopyrimidines from β-dicarbonyl compounds, DMF-DMA, and cyanamide, SDS of cas: 66373-25-9, the main research area is dicarbonyl preparation cyanamide DMF dimethylacetal DBU tandem multicomponent cyclocondensation; aminopyrimidine preparation regioselective; -Dicarbonyl compound; 2-Aminopyrimidine; Cyanamide; DBU; Domino synthesis; Four-component; MCR.

A multicomponent domino synthesis was developed for the preparation of 2-aminopyrimidines from β-dicarbonyl compounds, N,N-dimethylformamide di-Me acetal and cyanamide. The protocol was used for the regioselective preparation of 4-amide/ester/ketone substituted 2-aminopyrimidines. Twelve 2-aminopyrimidines were isolated in good yields (56-93%).

Molecular Diversity published new progress about Aromatic heterocyclic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 66373-25-9 belongs to class pyrimidines, name is 1-(2-Amino-4-methylpyrimidin-5-yl)ethanone, and the molecular formula is C7H9N3O, SDS of cas: 66373-25-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia