Category: 672-45-7

672-45-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 672-45-7, name is 2,4-Dihydroxy-6-trifluoromethylpyrimidine, the common compound, a new synthetic route is introduced below.

SYNTHESIS EXAMPLE 20 (2,4-dinitro-6-trifluoromethylphenyl)-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione (compound No. 5.65 of this invention) 1.0 g of 6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione was added to 10 ml of dimethylformamide, followed by addition of 0.65 g of sodium hydride (purity: 55%) with stirring at 0 C. The mixed solution was stirred at room temperature for 30 minutes, then cooled to 0 C. and added dropwise with a 5 ml dimethylformamide solution of 1.89 g of 2-chloro-3,5-dinitrobenzotrifluoride. After the solution was further stirred at room temperature for 3 hours, the solvent was distilled away under reduced pressure. After addition of cooled dilute hydrochloric acid thereto, the residue was extracted with 100 ml of ethyl acetate. The obtained organic layer was dried over anhydrous sodium sulfate and then the solvent was distilled away under reduced pressure to form a crude product. This crude product was recrystallized from a mixed solvent of chloroform and petroleum ether to obtain 0.77 g of the objective compound. M.p.: 219.0~220.5 C. 1 H-NMR (CDCl3 +CD3 OD, TMS, delta ppm): 6.10 (1H,s), 8.78 (1H,d,J=3.0 Hz), 9.08 (1H,d,J=3.0 Hz).

Statistics shows that 672-45-7 is playing an increasingly important role. we look forward to future research findings about 2,4-Dihydroxy-6-trifluoromethylpyrimidine.

Reference:
Patent; Nissan Chemical Industries Ltd.; US5116404; (1992); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

672-45-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 672-45-7, name is 2,4-Dihydroxy-6-trifluoromethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Reference Example 18. 6-Trifluoromethyl-1-(2-trimethylsilyl)ethoxymethylpyrimidine-2,4-dione In a similar manner to the procedures described in Reference Example 3, reactions were carried out using 6-trifluoromethylpyrimidine-2,4-dione, instead of pyrimidine-2,4-dione,and using 2-(trimethylsilyl)ethoxymethyl chloride, instead of benzyloxymethyl chloride, to give the title compound (yield 48%) as a colorless oil. 1H-Nuclear magnetic resonance spectrum (270 MHz, CDCl3) delta ppm: 8.84 (1H, br.s), 6.24 (1H, d, J=2Hz), 5.32 (2H, s), 3.73-3.68 (2H, m), 0.97-0.90 (2H, m), 0.01 (9H, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 672-45-7, 2,4-Dihydroxy-6-trifluoromethylpyrimidine.

Reference:
Patent; Sankyo Company Limited; EP1069110; (2001); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia