Category: 675-11-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 675-11-6, name is 4,6-Difluoropyrimidin-2-amine, the common compound, a new synthetic route is introduced below. Computed Properties of C4H3F2N3

EXAMPLE 3 Preparation of 2-amino-4-fluoro-6-propyloxypyrimidine (Variant A) STR11 29 4 g (0.3 mol) of potassium propylate were reacted as in Example 1 with 39.3 g (0.3 mol) of 2-amino-4,6-difluoropyrimidine in a total of 400 ml of n-propanol. The solvent was removed from the reaction mixture under reduced pressure, and the residue was washed with petroleum ether. It was subsequently stirred in water, filtered off, washed and dried, resulting in 36.1 g (70% of theory) of the title compound of melting point 63-66 C.

The synthetic route of 675-11-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF Aktiengesellschaft; US5011927; (1991); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.675-11-6, name is 4,6-Difluoropyrimidin-2-amine, molecular formula is C4H3F2N3, molecular weight is 131.0835, as common compound, the synthetic route is as follows.category: pyrimidines

EXAMPLE 5 Preparation of 6-allyloxy-2-amino-4-fluoropyrimidine (Variant A) STR13 1.14 g (0.0382 mol) of 80% sodium hydride (emulsion in linseed oil) were added at 25 C. under a nitrogen atmosphere to 70 ml of allyl alcohol. To the clear solution obtained after stirring at 40 C. for 20 minutes were added 5.0 g (0.0382 mol) of 2-amino-4,6-difluoropyrimidine, and the mixture was then stirred at 97 C. for 1.5 hours. To work up, the excess alcohol was removed by distillation under reduced pressure, the residue was taken up in methylene chloride, and the solution was washed with water, dried over magnesium sulfate and then freed of solvent. The viscous oil obtained in this way crystallized on trituration with n-pentane. 4.6 g (71.2% of theory) of the title compound of melting point 62-66 C. were obtained after filtering off, washing with water and drying.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,675-11-6, 4,6-Difluoropyrimidin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; BASF Aktiengesellschaft; US5011927; (1991); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 675-11-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 675-11-6, name is 4,6-Difluoropyrimidin-2-amine, molecular formula is C4H3F2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a sealable tube, a solution of 4,6-difluoropyrimidin-2-amine (1.0 g, 7.6 mmol) in 1,4-dioxane/dimethylformamide (20.0 mL, 1:1), potassium carbonate (1.6 g, 11.9 mmol) and tert-butylamine (1.7 g, 23.0 mmol) were added. The resulting reaction mixture was stirred at room temperature for 48 h. After completion, the reaction mixture was concentrated under reduced pressure. The crude material was diluted with cold water (10.0 mL) whereupon a solid formed. The solid was filtered and air dried to afford the title compound S7-2 (1.2 g, 85%) as an off-white solid. MS m/z (M+H): 185.1

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 675-11-6, 4,6-Difluoropyrimidin-2-amine.

Reference:
Patent; Celgene Avilomics Research, Inc.; Alexander, Matthew David; Chuaqui, Claudio; Malona, John; McDonald, Joseph John; Ni, Yike; Niu, Deqiang; Petter, Russell C.; Singh, Juswinder; (164 pag.)US2016/75720; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 675-11-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 675-11-6, name is 4,6-Difluoropyrimidin-2-amine. A new synthetic method of this compound is introduced below.

EXAMPLE 9 Preparation of 2-amino-6-(4-chlorophenoxy)-4-fluoropyrimidine (Variant A) STR17 2.52 g (0.038 mol) of 85% sodium hydroxide were dissolved in 50 ml of methanol, 4.9 g (0.0382 mol) of 4-chlorophenol were added, and the mixture was evaporated to dryness. The residue of salt obtained in this way was taken up in 50 ml of N-methyl-2-pyrrolidone and, at 25 C., 5.0 g (0.0382 mol) of 2-amino-4,6-difluoropyrimidine were added, and the mixture was stirred at 140 C. for 4 hours. After the reaction mixture had been cooled to 25 C. it was stirred into 500 ml of water, and the resulting precipitate was isolated. 7.4 g (81% of theory) of the title compound of melting point 223-226 C. were obtained in this way.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,675-11-6, 4,6-Difluoropyrimidin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; BASF Aktiengesellschaft; US5011927; (1991); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia