Category: 695-87-4

Reference of 695-87-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 695-87-4, name is 5-Methoxypyrimidin-4(1H)-one, molecular formula is C5H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A suspension of 1.9 g (0.015 mol) of 5-methoxy-3H-pyrimidin-4-one (Example P2) in 4.2 ml (0.046 mol) of phosphorus oxychloride and 5.0 mi (0.031 mol) of N, N-diethylaniline is heated at 115C for 3 hours. The dark, homogeneous mixture obtained is hydrolyse by adding crushed ice, the temperature being kept below 30C. Extraction with diethyl ether, drying of the combined organic ethereal phases over sodium sulfate, and purification on a silica gel column (eluant : ethyl acetate/n-hexane 1/9) yields the desired target compound in a yield of 1.3 g (58 % of theory). Further purification by means of sublimation at 80-85C/15 Torr yields the desired title compound, having a melting point of 63-64C. oh NMR (300 MHz, Ceci3) : 8.635 ppm (s, 1H) ; 8.321 ppm (s, 1H) ; 4.025 ppm (s, 3H).

According to the analysis of related databases, 695-87-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2003/87067; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 695-87-4, Adding some certain compound to certain chemical reactions, such as: 695-87-4, name is 5-Methoxypyrimidin-4(1H)-one,molecular formula is C5H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 695-87-4.

EXAMPLE 4 4-Chloro-5-methoxypyrimidine (VII) Materials: Procedure: To a stirred slurry of 4-hydroxy-5-methoxypyrimidine in toluene (171 mL) was added DIPEA and POCl3 at room temperature under nitrogen atmosphere, The reaction mixture was stirred for about 1-2 hours at 60 to 70 C. under nitrogen atmosphere to complete the reaction. The reaction was quenched by adding 90 mL of 1.55N NaOH at 5 to 8 C. and the aqueous phase was separated. The organic layer was washed with saturated NaHCO3 solution (31 mL) and polish filtered. Concentration of the intermediate was determined by HPLC quantitation. This 0.37 to 0.43M solution of chloromethoxypyrimidine was used without further purification,

According to the analysis of related databases, 695-87-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bristol-Myers Squibb Company; US5550239; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia