Category: 69543-98-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69543-98-2, name is 4-Bromo-6-methylpyrimidine, the common compound, a new synthetic route is introduced below. Formula: C5H5BrN2

Step 1: ieri-butyl 2-(3-acetyl-5-((6-methylpyrimidin-4-yl)oxy)-l.H-indazol-l-yl)acetate (235) [0734] A mixture of tert-hutyl 2-(3-acetyl-5-hydroxy-l.H-indazol-l-yl)acetate (1 equiv), 4-bromo-6-methylpyrimidine (1.1 equiv), K2CO3 (3 equivj and 18-Crown-6 (l equiv) in DMF HO vol) under argon, the pressure vessel was sealed and heated at 100 C for 24 h. The reaction mixture was cooled to rt and diluted with water, then extracted with DCM. The organic layer was washed with brine, dried over anhydrous Na2S04, filtered, and then concentrated . The residue was purified by column chromatography on silica gel (EtOAc/DCM) to give compound 235

The synthetic route of 69543-98-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (386 pag.)WO2017/35355; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69543-98-2, name is 4-Bromo-6-methylpyrimidine, the common compound, a new synthetic route is introduced below. Formula: C5H5BrN2

Step 1: ieri-butyl 2-(3-acetyl-5-((6-methylpyrimidin-4-yl)oxy)-l.H-indazol-l-yl)acetate (235) [0734] A mixture of tert-hutyl 2-(3-acetyl-5-hydroxy-l.H-indazol-l-yl)acetate (1 equiv), 4-bromo-6-methylpyrimidine (1.1 equiv), K2CO3 (3 equivj and 18-Crown-6 (l equiv) in DMF HO vol) under argon, the pressure vessel was sealed and heated at 100 C for 24 h. The reaction mixture was cooled to rt and diluted with water, then extracted with DCM. The organic layer was washed with brine, dried over anhydrous Na2S04, filtered, and then concentrated . The residue was purified by column chromatography on silica gel (EtOAc/DCM) to give compound 235

The synthetic route of 69543-98-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (386 pag.)WO2017/35355; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia