Category: 696-82-2

Application of 696-82-2 ,Some common heterocyclic compound, 696-82-2, molecular formula is C4HF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(1) adding 100% of a 2,4-diaminobenzenesulfonic acid solution (18.8 g) to 400 mL of water, stirring Add sodium bicarbonate solid, adjust the pH to 4, slowly warm to 20 C after dissolution, add 13.94 g (99%) 2,4,6-trifluoropyrimidine, control the pH at 4, continue the reaction 2 Hours, the end point of the reaction was detected by thin layer chromatography, and the reaction solution was used after the condensation was completed;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,696-82-2, its application will become more common.

Reference:
Patent; Jiangsu Demeike Chemical Co., Ltd.; Wang Siliang; Wang Xiaojun; (16 pag.)CN108129875; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 696-82-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 696-82-2, name is 2,4,6-Trifluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

(According to the process of prior German Patent Application P 39 00 471 (O.Z. 0050/40474)) At -20 C. and over a period of 45 minutes, 335.8 g (1.865 mol) of 30% strength sodium methylate (in methanol) was added to a mixture of 250 g (1.865 mol) of 2,4,6-trifluoropyrimidine, and the mixture was stirred for a further 30 minutes at this temperature. The temperature was then allowed to rise to 25 C., and the reaction mixture was evaporated down to about one fifth of its volume. The mixture obtained was partitioned between diethyl ether and water, after which the organic phase was dried over magnesium sulfate and evaporated down. Distillation (1.1 meter column, 3 mm V-shaped packings) gave 141.6 g (52% of theory) of the title compound of boiling point 144-145 C. Distillation of the residue through a fractionating column (from Normag) gave 114.4 g (42% of theory) of 4,6-difluoro-2-methoxypyrimidine of boiling point 157-161 C.

According to the analysis of related databases, 696-82-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BASF Aktiengesellschaft; US5276007; (1994); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

696-82-2 ,Some common heterocyclic compound, 696-82-2, molecular formula is C4HF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(3) N-(4-((4-(4,6-Difluoropyrimidin-2-yl)piperazin-1-yl)methyl)-phenylmethyl)acetamide To a solution of 2,4,6-trifluoropyrimidine (1.4 g) and potassium carbonate (2.1 g) in acetonitrile (30 ml) was added a solution of N-(4-((piperazin-1-yl)methyl)phenylmethyl)acetamide (2.5 g) in acetonitrile (20 ml) over 5 min under ice-cooling. The mixture was stirred at the same temperature for 1.5 hr. The reaction mixture was poured into water (100 ml) and extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give a white solid (3.2 g). The obtained white solid was purified by silica gel column chromatography (developing solvent; chloroform_methanol=50:1) to give a crude purification product (1.3 g) of N-(4-((4-(4,6-difluoropyrimidin-2-yl)piperazin-1-yl)methyl)phenylmethyl)acetamide and a crude purification product (1.1 g) of N-(4-((4-(2,6-difluoropyrimidin-4-yl)piperazin-1-yl)methyl)phenylmethyl)acetamide. The crude purification product of N-(4-((4-(4,6-difluoropyrimidin-2-yl)piperazin-1-yl)methyl)phenylmethyl)acetamide was crystallized from ethyl acetate:diisopropyl ether to give the title compound (1.0 g) as white crystals, m.p.=128-129 C. 1H-NMR(CDCl3)delta: 2.03(3H, s), 2.46(4H, t, J=5.3 Hz), 3.52(2H, s), 3.79(4H, t, J=5.3 Hz), 4.43(2H, d, J=5.3 Hz), 5.66(1H, t, J=1.3 Hz), 5.75(1H, brs), 7.23-7.32(4H, m); IR(KBr): 3288, 2918, 1635, 1552 cm-1; MS(EI): 361(M+); Elemental analysis: Calculated: C; 59.82, H; 5.86, N; 19.38; Found: C; 59.83, H; 5.85, N; 19.44.

According to the analysis of related databases, 696-82-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mitsubishi Pharma Corporation; US6455528; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

696-82-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 696-82-2, name is 2,4,6-Trifluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 2,4,6-trifluoropyrimidine (278 mg, 2.07 mmol) in Et20 (10 mL) is cooled to -20 C and is treated, dropwise, with a solution of tert-butyl 4-[[4-[(1S)-1- aminoethyllphenyllmethyllpiperazine-1-carboxylate (600 mg, 1.88 mmol) in Et20 (10 mL). The resulting mixture is stirred at -20 C for 1 hour and is then allowed to warm to room temperature and is stirred overnight. The solids are removed by filtration and arewashed with additional Et20. The filtrate is washed with water, using a small portion of NaC1 additive to reduce emulsification, and the aqueous layer is back-extracted with Et20 (lx) and CH2C12 (lx). The combined organic extracts are then dried (Na2SO4), filtered,and concentrated to give a crude product that is purified by silica gel chromatographyeluting with 20-60% EtOAc/hexanes to give the title compound as a pale yellow oil (606 mg, 1.40 mmol, 74%). ES/MS (mlz): 434 (M+H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 696-82-2, 2,4,6-Trifluoropyrimidine.

Reference:
Patent; ELI LILLY AND COMPANY; LUMERAS AMADOR, Wenceslao; BAUER, Renato A.; BOULET, Serge Louis; BURKHOLDER, Timothy Paul; GILMOUR, Raymond; HAHN, Patric James; CARBALLARES MARTIN, Santiago; RANKOVIC, Zoran; (80 pag.)WO2017/213910; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

696-82-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 696-82-2, name is 2,4,6-Trifluoropyrimidine. A new synthetic method of this compound is introduced below.

Example 1 0.5 mol of fluorine in the form of a 30% by volume mixture with helium was introduced into a suspension of 29.0 g (0.216 mol) of 2,4,6-trifluoropyrimidine, 21 g of sodium fluoride (0.5 mol) and 250 ml of trichlorofluoromethane at a temperature of -78 C. The rate of introduction was 0.15 mol of fluorine per hour. After the introduction was complete, the reaction mixture was filtered and 21.0 g of tetrafluoropyrimidine (=64% of theory) were obtained from the filtrate by distillation.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,696-82-2, 2,4,6-Trifluoropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Bayer Aktiengesellschaft; US5145961; (1992); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

696-82-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 696-82-2, name is 2,4,6-Trifluoropyrimidine. A new synthetic method of this compound is introduced below.

(1) 21.0 parts of sodium 2,4_ diamino benzene sulfonate (to, hereinafter referred to as double) dissolved in 200 parts of water, then add13.5 parts of trifluoropyrimidine at a temperature of 15 C, a pH of 5 conditions, condensation 4. 0h, to obtain a condensation product;

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 696-82-2, 2,4,6-Trifluoropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu Demeike Chemical Co., Ltd.; Wang Xiaojun; (8 pag.)CN106398298; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia