Category: 69696-35-1

Sakamoto, Takao’s team published research in Synthesis in 1984 | CAS: 69696-35-1

5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Computed Properties of C6H6BrClN2

Computed Properties of C6H6BrClN2On March 31, 1984, Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi published an article in Synthesis. The article was 《Studies on pyrimidine derivatives; XXXV. Iodination of 2-aminopyrimidines, 4-aminopyrimidines, and 4-pyrimidinones with iodine chloride in situ》. The article mentions the following:

Iodination of pyrimidines I (R = H, Me, Me2CH, Ph; R1 = NH2; R2 = H; R3 = Me) with ICl generated in situ in AcOH gave 42-55% I (R, R1, R3 = same as above; R2 = I). Similarly, II (R, R2, R3 same as above) gave 51-72% II (R2 = I), which was chlorinated with POCl3 to give I (R, R3 = same, R1 = Cl, R2 = I), which was dechlorinated with p-MeC6H4SO2NHNH2 and Na2CO3 to give 77-87% I (R, R3 = same, R1 = H, R2 = I).5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1Computed Properties of C6H6BrClN2) was used in this study.

5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Computed Properties of C6H6BrClN2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Huang, Ying’s team published research in Journal of Medicinal Chemistry in 2022 | CAS: 69696-35-1

5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 69696-35-1

《Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies》 was written by Huang, Ying; Sendzik, Martin; Zhang, Jeff; Gao, Zhenting; Sun, Yongfeng; Wang, Long; Gu, Justin; Zhao, Kehao; Yu, Zhengtian; Zhang, Lijun; Zhang, Qiong; Blanz, Joachim; Chen, Zijun; Dubost, Valerie; Fang, Douglas; Feng, Lijian; Fu, Xingnian; Kiffe, Michael; Li, Ling; Luo, Fangjun; Luo, Xiao; Mi, Yuan; Mistry, Prakash; Pearson, David; Piaia, Alessandro; Scheufler, Clemens; Terranova, Remi; Weiss, Andreas; Zeng, Jue; Zhang, Hailong; Zhang, Jiangwei; Zhao, Mengxi; Dillon, Michael P.; Jeay, Sebastien; Qi, Wei; Moggs, Jonathan; Pissot-Soldermann, Carole; Li, En; Atadja, Peter; Lingel, Andreas; Oyang, Counde. Application of 69696-35-1 And the article was included in Journal of Medicinal Chemistry on April 14 ,2022. The article conveys some information:

Polycomb Repressive Complex 2 (PRC2) plays an important role in transcriptional regulation during animal development and in cell differentiation, and alteration of PRC2 activity has been associated with cancer. On a mol. level, PRC2 catalyzes methylation of histone H3 lysine 27 (H3K27), resulting in mono-, di-, or trimethylated forms of H3K27, of which the trimethylated form H3K27me3 leads to transcriptional repression of polycomb target genes. Previously, we have shown that binding of the low-mol.-weight compound EED226 to the H3K27me3 binding pocket of the regulatory subunit EED can effectively inhibit PRC2 activity in cells and reduce tumor growth in mouse xenograft models. Here, we report the stepwise optimization of the tool compound EED226 toward the potent and selective EED inhibitor MAK683 (compound 22) and its subsequent preclin. characterization. Based on a balanced PK/PD profile, efficacy, and mitigated risk of forming reactive metabolites, MAK683 has been selected for clin. development.5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1Application of 69696-35-1) was used in this study.

5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application of 69696-35-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Edo, Kiyoto’s team published research in Chemical & Pharmaceutical Bulletin in 1978 | CAS: 69696-35-1

5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Synthetic Route of C6H6BrClN2

Edo, Kiyoto; Sakamoto, Takao; Yamanaka, Hiroshi published their research in Chemical & Pharmaceutical Bulletin on December 31 ,1978. The article was titled 《Studies on pyrimidine derivatives. IX. Coupling reaction of mono-substituted acetylenes with iodopyrimidines》.Synthetic Route of C6H6BrClN2 The article contains the following contents:

Pyrimidine derivatives containing an acetylenic side chain were prepared by reaction of alkyl or Ph acetylenes with 2-, 4-, and 5-iodopyrimidines in the presence of Pd(PPh3)2Cl2. When HCCCH2OH was used, the reaction yield decreased. The reaction proceeded with 2,4-diiodo- and 4,6-diiodopyrimidines to give dialkynyl derivatives This acetylene coupling reaction was applicable to the preparation of 4-quinazoline derivatives The results came from multiple reactions, including the reaction of 5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1Synthetic Route of C6H6BrClN2)

5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Synthetic Route of C6H6BrClN2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Kondo, Yoshinori’s team published research in Chemical & Pharmaceutical Bulletin in 1989 | CAS: 69696-35-1

5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Formula: C6H6BrClN2

Formula: C6H6BrClN2On October 31, 1989 ,《Studies on pyrimidine derivatives. XLI. Palladium-catalyzed cross-coupling reaction of halopyrimidines with aryl- and vinyltributylstannanes》 appeared in Chemical & Pharmaceutical Bulletin. The author of the article were Kondo, Yoshinori; Watanabe, Ryo; Sakamoto, Takao; Yamanaka, Hiroshi. The article conveys some information:

The arylation of 2-, 4-, and 5-halopyrimidines with aryltributylstannanes in the presence of dichlorobis(triphenylphosphine)palladium was investigated with successful results. The reaction can be expanded to the synthesis of 2-, 4-, and 5-vinylpyrimidines with generality. Thus the reaction of pyrimidine I (R = Cl) with R1SnBu3 (R1 = Ph, 2-thienyl, vinyl) gave I (R = R1). After reading the article, we found that the author used 5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1Formula: C6H6BrClN2)

5-Bromo-4-chloro-2,6-dimethylpyrimidine(cas: 69696-35-1) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Formula: C6H6BrClN2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Share a compound : 5-Bromo-4-chloro-2,6-dimethylpyrimidine

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 69696-35-1, 5-Bromo-4-chloro-2,6-dimethylpyrimidine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 69696-35-1, name is 5-Bromo-4-chloro-2,6-dimethylpyrimidine. A new synthetic method of this compound is introduced below., COA of Formula: C6H6BrClN2

c) 5-bromo-2,4-dimethylpyrimidine. A mixture of 5-bromo-4-chloro-2,6- dimethylpyrimidine (2.73 g, 12.33 mmol), 4-methylbenzenesulfonohydrazide (4.19 mL, 37.0 mmol) and chloroform (40 mL) was heated at 90 C for 16 hours. The solution was cooled and the solid filtered and washed with chloroform. LCMS revealed this solid (4.75g) was the desired intermediate. A mixture of this solid and 0.94M aqueous sodium carbonate (40 mL, 37.7 mmol) was heated at 90 C for 1 .5 hours. The cooled solution was extracted with ethyl acetate 3 times, and the combined organics were washed with brine, dried (Na2S04) and concentrated to afford the title compound (1 .17 g, 51 %) as a tan oil, which crystallized upon standing. LCMS (ES+) m/e 187 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 69696-35-1, 5-Bromo-4-chloro-2,6-dimethylpyrimidine.

Reference:
Patent; GLAXOSMITHKLINE LLC; BROWN, Kristin, K.; CHAI, Deping; DODSON, Christopher, S.; DUFFY, Kevin, J.; SHAW, Antony, Nicholas; WO2013/96151; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia