Category: 6972-27-6

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6972-27-6, name is 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, molecular formula is C6H7ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C6H7ClN2O2

Step 2: 6-(hydroxyamino)-l,3-dimethylpyrimidine-2,4(lH,3H)-dione: A solution of Step 1 intermediate (10 g, 57.261 mmol), hydroxylamine hydrochloride (12.15 g, 176.361 mmol) and sodium acetate (33.81 g, 412.28 mmol) in isopropyl alcohol (280 ml) were refluxed for 4 h. The reaction mixture was concentrated under reduced pressure, diluted with water and stirred for 1 h. The precipitated solid was collected by filtration, washed with water (25 ml) and dried to obtain 9.56 g of the product as a pale brown solid; NMR (300 MHz, DMSO-i/6) delta 3.07 (s, 3H), 3.16 (s, 3H), 3.67 (s, 2H), 10.45 (br s, lH).

With the rapid development of chemical substances, we look forward to future research findings about 6972-27-6.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; CHAUDHARI, Sachin, Sundarlal; KUMAR, Sukeerthi; THOMAS, Abraham; PATIL, Nisha, Parag; KADAM, Ashok, Bhausaheb; WAGHMARE, Nayan, Taterao; KHAIRATKAR-JOSHI, Neelima; MUKHOPADHYAY, Indranil; WO2011/114184; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 6972-27-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6972-27-6, name is 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, molecular formula is C6H7ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3-[4-(2-Methoxyphenyl)piperazin-1-yl]propylamine (50.00 g, 0.20 mol) was added to a 500 ml clean three-neck reaction flask.And 6-chloro-1,3-dimethyluracil purified water(35.01g, 0.20mol), anhydrous sodium carbonate (63.59g, 0.60mol)And purified water (500ml), mechanically stirred, heated to 60 C for 2 hours,The temperature was lowered to room temperature, suction filtered, and the filter cake was blast dried at 50 C for 6 hours to obtain 66.23 g of urapidil.The yield was 85.2% and the purity was 97.9%.

According to the analysis of related databases, 6972-27-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hebei Yipin Pharmaceutical Co., Ltd.; Zhang Ji; Chen Wenhui; Lv Shuai; Liu Xuesong; Duan Shibao; Li Minghao; Cheng Yao; Zhao Cuiran; Zhang Yongran; (7 pag.)CN109516960; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6972-27-6, 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

Method C: The stirred solution of solution of 6-chloro-l ,3-dimethylpyrimidine- 2,4(lH,3H)-dione (1 Kg) in ethanol (12 L) was added portion wise sodium hydrosulphide hydrate (1 kg) over a period of 1 h at 0 to 5C. After addition, the reaction mixture was stirred at 25 to 30C for 2 h. The reaction mixture was filtered and washed with ethanol (2 L). The filtrate was collected and concentrated under vacuum to obtain residue which was then dissolved in water (8 L). The aqueous solution was washed with dichloromethane (3 L) followed by petroleum ether (2 L). The aqueous layer was separated and was acidified using hydrochloric acid solution [4 L, cone, hydrochloric acid and water (1 : 1)]. The precipitated solid was filtered and washed with water followed by ethanol and dried to obtain the 0.8 Kg of the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6972-27-6, 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; KADAM, Suresh Mahadev; THOMAS, Abraham; SINHA, Sukumar; KUMAR, Sukeerthi; KANSAGRA, Bipin Parsottam; GAVHANE, Sachin; KHANDAGALE, Sandeep Bandu; PAWASE, Shailesh; PATIL, Jayant Prakashrao; BHADANE, Shailendra; MISHRA, Bhavna; DWIVEDI, Rajesh; WO2013/183035; (2013); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 6972-27-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6972-27-6, name is 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A solution of the above crude N-substituted benzamidine (10.0mmol) in DMF (5 mL) was added dropwise at 0 C to a solution of NaH (20.0 mmol) in DMF (5 mL) and stirred for 30 min. A solution of 1,3-dimethyl-6-chlorouracil (5.0 mmol) in DMF (5 mL) was added dropwise at 0 C and the reaction mixture was stirred at 80 C overnight. Sat. aq NH4Cl (20 mL) was added at 0 C and the mixture was extracted with EtOAc (5 × 10 mL). The combined organic phases were washed with H2O (2 × 10 mL) and brine (1 × 10 mL), and dried (MgSO4). The solvent was removed under reduced pressure and the crude material was purified by silica gel column chromatography to give 1a-e,h,k-o.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6972-27-6, 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione.

Reference:
Article; Shimizu, Maki; Hayama, Noboru; Kimachi, Tetsutaro; Inamoto, Kiyofumi; Synthesis; vol. 49; 18; (2017); p. 4183 – 4190;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 6972-27-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6972-27-6 as follows.

General procedure: A solution of the above crude N-substituted benzamidine (10.0mmol) in DMF (5 mL) was added dropwise at 0 C to a solution of NaH (20.0 mmol) in DMF (5 mL) and stirred for 30 min. A solution of 1,3-dimethyl-6-chlorouracil (5.0 mmol) in DMF (5 mL) was added dropwise at 0 C and the reaction mixture was stirred at 80 C overnight. Sat. aq NH4Cl (20 mL) was added at 0 C and the mixture was extracted with EtOAc (5 × 10 mL). The combined organic phases were washed with H2O (2 × 10 mL) and brine (1 × 10 mL), and dried (MgSO4). The solvent was removed under reduced pressure and the crude material was purified by silica gel column chromatography to give 1a-e,h,k-o.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6972-27-6, its application will become more common.

Reference:
Article; Shimizu, Maki; Hayama, Noboru; Kimachi, Tetsutaro; Inamoto, Kiyofumi; Synthesis; vol. 49; 18; (2017); p. 4183 – 4190;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 6972-27-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6972-27-6, name is 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.

General procedure: A mixture of (18a) (69 mg, 0.176 mmol), 6-chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione (61 mg, 0.35 mmol) and diisopropylethylamine (0.152 mL, 0.880 mmol) in isopropyl alcohol (0.5 mL) was heated at 80 C for 7 h. The reaction mixture was diluted with ethyl acetate, washed with satd NaHCO3 and brine, dried over NaSO4, and the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane, and then MeOH/CHCl3) to give methyl 2-(11-(3-(4-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperazin-1-yl)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate (87 mg, 93% yield) as amorphous.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6972-27-6, its application will become more common.

Reference:
Article; Kubota, Katsumi; Kurebayashi, Hirotaka; Miyachi, Hirotaka; Tobe, Masanori; Onishi, Masako; Isobe, Yoshiaki; Bioorganic and Medicinal Chemistry; vol. 19; 9; (2011); p. 3005 – 3021;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 6972-27-6 , The common heterocyclic compound, 6972-27-6, name is 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, molecular formula is C6H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 6 (15 g, 74.5 mmol) was added portionwise to a cooled solution of cone. H2S04 (40 mL) . The reaction temperature was maintained below 10 C. Fuming nitric acid (15 mL) was added dropwise to the above reaction mixture and it was stirred for 2 h at the same temperature. The reaction nixture was poured onto the ice cold water (500 mL) and extracted with chloroform (2×260 mL). The combined organic extracts were washed with water (260 mL), dried over anhydrous Na2S04 and concentrated in vacuo to give the title compound (12.0 g) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta (ppm): 3.07 and 3.26 (both s, both 3H)

The synthetic route of 6972-27-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LATVIAN INSTITUTE OF ORGANIC SYNTHESIS; ARSENJANS, Pavels; VASILJEVA, Jelena; DOMRACHEVA, llona; SHESTAKOVA, Irina; GULBE, Anita; KANEPE-LAPSA, Iveta; KAUSS, Valerjans; KALVINS, Ivars; (33 pag.)WO2016/159747; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia