Category: 70227-50-8

Related Products of 70227-50-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 70227-50-8, name is 2-(tert-Butyl)-4-chloro-5-nitropyrimidine, molecular formula is C8H10ClN3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of compound O.5 (12 g, 55.7 mmol) in methanol (96 mL) was added ammonium hydroxide solution (156 mL) at 0-5 C. The reaction was warmed to RT and stirred overnight. The mixture was concentrated in vacuo, and the residue was dissolved in water and extracted with DCM. The organic layer was dried (Na2SO4) and concentrated in vacuo to afford compound O.6, 2-tert-butyl-5-nitropyrimidin-4-amine, as a light green solid (8.4 g, 77%). 1H NMR (CDCl3, 200 MHz) delta 9.2 (s, 1 H), 7.8 (br. s, 1 H), 6.0 (br. s, 1 H), 1.38 (s, 9 H); LCMS: m/z 197.0 [M+1]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 70227-50-8, 2-(tert-Butyl)-4-chloro-5-nitropyrimidine.

Reference:
Patent; Sunesis Pharmaceuticals, Inc.; US2009/36419; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 70227-50-8 ,Some common heterocyclic compound, 70227-50-8, molecular formula is C8H10ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of compound 270.1 (1 g, 4.6 mmol, WO2006065703) in MeOH (3 ml) was added triethylamine (1 ml, 2 eq) in a sealed tube and stirred at 80 C for 2 hr. After completion of the starting material (by TLC), the reaction mixture was cooled to room temperature and evaporated under reduced pressure. The crude material was diluted with water (15 ml) and extracted with EtOAc (2×15 ml). The combined organic layers was washed with brine solution and dried over Na2SO^ The solvent was evaporated under reduced pressure to afford compound 270.2 (700 mg, 71%) as yellowish oil. 1H-NMR (CDCl3, 200 MHz): delta 9.12 (s, 1H), 4.18 (s, 1H), 1.41 (s, 9H). LCMS m/z = 212 [M+l].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,70227-50-8, its application will become more common.

Reference:
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; CHUAQUI, Claudio; COSSROW, Jennifer; DOWLING, James; GUAN, Bing; HOEMANN, Michael; ISHCHENKO, Alexey; JONES, John, Howard; KABIGTING, Lori; KUMARAVEL, Gnanasambandam; PENG, Hairuo; POWELL, Noel; RAIMUNDO, Brian; TANAKA, Hiroko; VAN VLOTEN, Kurt; VESSELS, Jeffrey; XIN, Zhili; WO2010/78408; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 70227-50-8, name is 2-(tert-Butyl)-4-chloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

Synthesis of Compound O.6. To a stirred solution of compound O.5 (12 g, 55.7 mmol) in methanol (96 mL) was added ammonium hydroxide solution (156 mL) at 0-5 C. The reaction was warmed to RT and stirred overnight. The mixture was concentrated in vacuo, and the residue was dissolved in water and extracted with DCM. The organic layer was dried (Na2SO4) and concentrated in vacuo to afford compound O.6, 2-tert-butyl-5-nitropyrimidin-4-amine, as a light green solid (8.4 g, 77%). 1H NMR (CDCl3, 200 MHz) delta 9.2 (s, 1H), 7.8 (br. s, 1 H), 6.0 (br. s, 1H), 1.38 (s, 9H); MS: m/z 197.0 [M+1]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 70227-50-8, 2-(tert-Butyl)-4-chloro-5-nitropyrimidine.

Reference:
Patent; Sunesis Pharmaceuticals, Inc; US2009/5359; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 70227-50-8, name is 2-(tert-Butyl)-4-chloro-5-nitropyrimidine, molecular formula is C8H10ClN3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2-(tert-Butyl)-4-chloro-5-nitropyrimidine

Compound 3.4 was dissolved in MeOH (1 mL) and ammonium hydroxide solution (1.5 mL) was added. The reaction mixture was stirred overnight. After removal of excess ammonia and MeOH, the mixture was extracted with chloroform. After drying with anhydrous sodium sulfate and removal of the solvent, compound 3.5 (89 mg, ~78%) was obtained and used without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 70227-50-8.

Reference:
Patent; SUNESIS PHARMACEUTICALS, INC.; WO2006/65703; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia