Category: 7043-09-6

Synthetic Route of 7043-09-6 ,Some common heterocyclic compound, 7043-09-6, molecular formula is C7H6Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of NaOMe (0.143 g, 2.64 mmol) in methanol (25.0 mL) was added 4,6-dichloro-2-cyclopropylpyrimidine (0.500 g, 2.64 mmol) at RT. The reaction solution was stirred at RT for 2 h. The resulting mixture was diluted with water (70 mL) and extracted with ethyl acetate (3 x 50 mL). The combined organic extracts were washed with brine (50 mL), dried with anhydrous Na2SC>4 and filtered. The filtrate was concentrated under reduced pressure. The crude title compound was obtained as a solid and was used in the next step without further purification. MS = 185.1/187.1 (M+l).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7043-09-6, 4,6-Dichloro-2-cyclopropylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; SHEN, Dong-Ming; YANG, Meng; CRESPO, Alexander; WILSON, Jonathan, E.; MCCRACKEN, Troy; WANG, Deping; PARKER, Dann; GUO, Zack Zhiqiang; (135 pag.)WO2016/154081; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7043-09-6, name is 4,6-Dichloro-2-cyclopropylpyrimidine, molecular formula is C7H6Cl2N2, molecular weight is 189.04, as common compound, the synthetic route is as follows.category: pyrimidines

To a suspension of Nal (2.10 g, 13.7 mmol) in HI (55%, 10 mL) was added 4,6-dichloro-2- cyclopropylpyrimidine (2.00 g, 10.6 mmol). The resulting mixture was warmed to 40 C and stirred for 1 hour. The reaction mixture was cooled to rt and diluted with H20 (100 mL) and stirred for 15 mm. The mixture was filtered to give the title compound (2.9 g, yield 74%) as ayellow solid.1H NMR (300 MHz, CDCI3): oe 7.95 (s, 1H), 2.21-2.12 (m, 1H), 1.15-1.09 (m, 4H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7043-09-6, 4,6-Dichloro-2-cyclopropylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; DING, Xiao; JIN, Yun; LIU, Qian; REN, Feng; SANG, Yingxia; STASI, Luigi Piero; WAN, Zehong; WANG, Hailong; XING, Weiqiang; ZHAN, Yang; ZHAO, Baowei; (573 pag.)WO2017/12576; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia