Adding a certain compound to certain chemical reactions, such as: 71082-53-6, name is 8-Fluoroquinoline-3-carboxylic acid, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 71082-53-6, SDS of cas: 71082-53-6
To a suspension of 8-fluoroquinoline-3-carboxylic acid (3 g, 14.9 mmol) in dichloromethane (37 mL), N,N-dimethylformamide (0.1 mL) was added followed by oxalyl chloride (1 .4 mL, 15.5 mmol) over a period of 30 minutes at room temperature. Vigorous gas evolution was observed. The white suspension was stirred for 4 h until the gas evolution came completely to an end. The pale yellow suspension was checked by LCMS of a small sample (quenched with EtNhb) showing still traces of acid (M+H+=192) and the amide (M+H+=219). Analysis of crude NMR of the acid chloride was performed: 1H NMR (400 MHz, CDCI3) delta ppm 9.50 – 9.63 (m, 1 H), 9.06 – 9.20 (m, 1 H), 7.87 – 7.98 (m, 1 H), 7.75 (s, 1 H), 7.64 – 7.83 (m, 2 H).
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