Category: 71470-41-2

Electric Literature of 71470-41-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 71470-41-2, name is Ethyl 4-aminopyrimidine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Example 264a 2-(4-Aminopyrimidin-2-yl)propan-2-ol 264a To a solution of ethyl 4-aminopyrimidine-2-carboxylate (840 mg, 5.0 mmol) in anhydrous tetrahydrofuran (50 mL) cooled at -20 C was added a solution of methylmagnesium bromide in THF (8.5 mL, 25.0 mmol, 3.0 M) over a period of 5 minutes. The reaction mixture was stirred at 0C for another 2 h. It was then quenched with saturated NH4Cl (20 mL) and concentrated under reduced pressure. The residue was extracted with ethyl acetate (5 X 40 mL). The combined organic layer was dried over anhydrous Mg2SO4, filtered, and evaporated under reduced pressure. The residue was purified by reverse-phase Combiflash to afford 264a as yellow solid (240 mg, 32%) MS-ESI: [M+H]+ 154.1

According to the analysis of related databases, 71470-41-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F.Hoffmann-La Roche AG; CRAWFORD, James John; ORTWINE, Daniel Fred; WEI, BinQing; YOUNG, Wendy B.; EP2773638; (2015); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 71470-41-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.71470-41-2, name is Ethyl 4-aminopyrimidine-2-carboxylate, molecular formula is C7H9N3O2, molecular weight is 167.17, as common compound, the synthetic route is as follows.

(1) A mixture of formic acid (100 g) and acetic anhydride (204 g) was stirred for half an hour at ambient temperature. To the solution was added ethyl 4-aminopyrimidine-2-carboxylate (30 g) and the mixture was stirred for 1.5 hours at 70 to 75 C. and then evaporated to dryness. The residue was triturated with ethanol, collected by filtration and washed with ethanol to give ethyl 4-formamidopyrimidine-2-carboxylate (20.0 g), mp 205-206 C. I.R. nu maxNujol: 3100, 1720, 1630, 1570, 1520 cm-1.

Statistics shows that 71470-41-2 is playing an increasingly important role. we look forward to future research findings about Ethyl 4-aminopyrimidine-2-carboxylate.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US4267176; (1981); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia